The alpha-1B adrenergic receptor (α
1B-adrenoreceptor), also known as ADRA1B, is an
alpha-1 adrenergic receptor
alpha-1 (α1) adrenergic receptors are G protein-coupled receptors (GPCRs) associated with the Gq heterotrimeric G protein. α1-adrenergic receptors are subdivided into three highly homologous subtypes, i.e., α1A-, α1B-, and α1D-adrenerg ...
, and also denotes the human
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
encoding it.
The crystal structure of the α
1B-adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin.
Receptor
There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.
Gene
This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a
protooncogene. This gene comprises 2
exons and a single large intron of at least 20 kb that interrupts the coding region.
Ligands
; Antagonists
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L-765,314
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Risperidone
Risperidone, sold under the brand name Risperdal among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder. It is taken either by mouth or by injection (subcutaneous or intramuscular). The injectable versions ...
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Brexpiprazole
Interactions
Alpha-1B adrenergic receptor has been shown to
interact with
AP2M1.
A role in regulation of dopaminergic neurotransmission has also been suggested.
See also
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Adrenergic receptor
References
External links
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Further reading
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Adrenergic receptors
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