Hermann Adolf Alexander Schmidt ( – ) was a

Baltic German Baltic Germans (german: Deutsch-Balten or , later ) were ethnic German inhabitants of the eastern shores of the Baltic Sea, in what today are Estonia and Latvia. Since their coerced resettlement in 1939, Baltic Germans have markedly declined ...

physiologist from what was then the

Governorate of Livonia The Governorate of Livonia, also known as the Livonia Governorate, was a Baltic governorate of the Russian Empire, now divided between Latvia and Estonia. Geography The shape of the province is a fairly rectangular in shape, with a maximum ...

in the

Russian Empire The Russian Empire was an empire and the final period of the Russian monarchy from 1721 to 1917, ruling across large parts of Eurasia. It succeeded the Tsardom of Russia following the Treaty of Nystad, which ended the Great Northern War. ...

. He was born on the island of Moon, which is today known by its Estonian name

Muhu Muhu (also called Muhumaa in Estonian), is an island in the West Estonian archipelago of the Baltic Sea. With an area of it is the third largest island belonging to Estonia, after Saaremaa and Hiiumaa. Together with neighbouring smaller is ...

, in present-day

Estonia Estonia, formally the Republic of Estonia, is a country by the Baltic Sea in Northern Europe. It is bordered to the north by the Gulf of Finland across from Finland, to the west by the sea across from Sweden, to the south by Latvia, a ...

. In 1858, he received his medical doctorate from the

University of Dorpat The University of Tartu (UT; et, Tartu Ülikool; la, Universitas Tartuensis) is a university in the city of Tartu in Estonia. It is the national university of Estonia. It is the only classical university in the country, and also its biggest ...

, and later was an assistant to

Felix Hoppe-Seyler Ernst Felix Immanuel Hoppe-Seyler (''né'' Felix Hoppe; 26 December 1825 – 10 August 1895) was a German physiologist and chemist, and the principal founder of the disciplines of biochemistry and molecular biology. Biography Hoppe-Seyler was b ...

(1825-1895) in

Berlin Berlin ( , ) is the capital and List of cities in Germany by population, largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's List of cities in the European Union by population within ci ...

, and to

Carl Ludwig Carl Friedrich Wilhelm Ludwig (; 29 December 1816 – 23 April 1895) was a German physician and physiologist. His work as both a researcher and teacher had a major influence on the understanding, methods and apparatus used in almost all branches ...

(1816-1895) in

Leipzig Leipzig ( , ; Upper Saxon: ) is the most populous city in the German state of Saxony. Leipzig's population of 605,407 inhabitants (1.1 million in the larger urban zone) as of 2021 places the city as Germany's eighth most populous, as ...

. In 1869 he succeeded Friedrich Bidder (1810-1894) as professor of physiology at Dorpat, where he remained for the rest of his life. From 1885 to 1889 he served as university rector. Schmidt is remembered for his research involving the process of blood coagulation by demonstrating that the transformation of

fibrinogen Fibrinogen (factor I) is a glycoprotein complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood cl ...

into fibrin was the result of an

enzymatic Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. ...

process. He named the hypothetical enzyme "

thrombin Thrombin (, ''fibrinogenase'', ''thrombase'', ''thrombofort'', ''topical'', ''thrombin-C'', ''tropostasin'', ''activated blood-coagulation factor II'', ''blood-coagulation factor IIa'', ''factor IIa'', ''E thrombin'', ''beta-thrombin'', ''gamma- ...

", and he called its precursor "

prothrombin Thrombin (, ''fibrinogenase'', ''thrombase'', ''thrombofort'', ''topical'', ''thrombin-C'', ''tropostasin'', ''activated blood-coagulation factor II'', ''blood-coagulation factor IIa'', ''factor IIa'', ''E thrombin'', ''beta-thrombin'', ''gamma- ...

". Schmidt is credited for providing a foundation for the creation of anti-coagulation systems and towards the development of

blood transfusion Blood transfusion is the process of transferring blood products into a person's circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used whole blood, but mo ...

Selected works

* ''Weiteres über den Faserstoff und die Ursachen seiner Gerinnung'', 1862 – More information involving "faserstoff" and the causes of its coagulation. * ''Ueber Ozon im Blut'', 1862. (habilitation thesis for

privat-docent ''Privatdozent'' (for men) or ''Privatdozentin'' (for women), abbreviated PD, P.D. or Priv.-Doz., is an academic title conferred at some European universities, especially in German-speaking countries, to someone who holds certain formal qualific ...

). 1862 – On

ozone Ozone (), or trioxygen, is an inorganic molecule with the chemical formula . It is a pale blue gas with a distinctively pungent smell. It is an allotrope of oxygen that is much less stable than the diatomic allotrope , breaking down in the lo ...

in the blood. * ''Beiträge zur Kenntniss der Milch'', 1874 – Contributions to the understanding of milk. * ''Die Lehre von den fermentativen Gerinnungserscheinungen in den eiweissartigen thierischen Körperflüssigkeiten'', 1876. The doctrine of the fermentative coagulation phenomena in albuminous animal body fluids. * ''Zur Blutlehre''. Leipzig, F. C. W. Vogel, 1892 – Lessons on blood.Bibliography of Schmidt
@

Who Named It ''Whonamedit?'' is an online English-language dictionary of medical eponyms and the people associated with their identification. Though it is a dictionary, many eponyms and persons are presented in extensive articles with comprehensive bibliograp ...

References

External links

Hemophilia Federation
The Coagulation Process

1831 births 1894 deaths People from Muhu Parish People from the Governorate of Livonia Baltic-German people German physiologists University of Tartu faculty Rectors of the University of Tartu {{Germany-med-bio-stub