Albert Bruce Sabin ( ; August 26, 1906 – March 3, 1993) was a Polish-American medical researcher, best known for developing the oral polio vaccine, which has played a key role in nearly eradicating the disease. In 1969–72, he served as the president of the

Weizmann Institute of Science The Weizmann Institute of Science ( he, מכון ויצמן למדע ''Machon Vaitzman LeMada'') is a public research university in Rehovot, Israel, established in 1934, 14 years before the State of Israel. It differs from other Israeli unive ...

in Israel.

Biography

Abram Saperstejn (later Albert Sabin) was born in

Białystok Białystok is the largest city in northeastern Poland and the capital of the Podlaskie Voivodeship. It is the tenth-largest city in Poland, second in terms of population density, and thirteenth in area. Białystok is located in the Białystok U ...

Russian Empire The Russian Empire was an empire and the final period of the Russian monarchy from 1721 to 1917, ruling across large parts of Eurasia. It succeeded the Tsardom of Russia following the Treaty of Nystad, which ended the Great Northern War ...

(before and since 1918 in

Poland Poland, officially the Republic of Poland, is a country in Central Europe. It is divided into 16 administrative provinces called voivodeships, covering an area of . Poland has a population of over 38 million and is the fifth-most populou ...

), to

Polish-Jewish The history of the Jews in Poland dates back at least 1,000 years. For centuries, Poland was home to the largest and most significant Ashkenazi Jewish community in the world. Poland was a principal center of Jewish culture, because of the l ...

parents, Jacob Saperstejn and Tillie Krugman. In 1921, he emigrated with his family on the SS ''Lapland'' which sailed from Antwerp, Belgium, to the Port of New York. In 1930, he became a naturalized citizen of the United States and changed his name to Sabin, as well as assuming the middle name Bruce. He graduated from high school in

Paterson, New Jersey Paterson ( ) is the largest city in and the county seat of Passaic County, in the U.S. state of New Jersey. Sabin began university in a dentistry program, but was interested in

virology Virology is the scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host cells for reproduction, the ...

and changed majors. He received a bachelor's degree in science in 1928 and a medical degree in 1931 from

New York University New York University (NYU) is a private research university in New York City. Chartered in 1831 by the New York State Legislature, NYU was founded by a group of New Yorkers led by then- Secretary of the Treasury Albert Gallatin. In 1832, th ...

. In 1983, Sabin developed calcification of the cervical spine, which caused paralysis and intense pain. Sabin revealed in a television interview that the experience had made him decide to spend the rest of his life working on alleviating pain. This condition was successfully treated by surgery conducted at

Johns Hopkins Hospital The Johns Hopkins Hospital (JHH) is the teaching hospital and biomedical research facility of the Johns Hopkins School of Medicine, located in Baltimore, Maryland, U.S. It was founded in 1889 using money from a bequest of over $7 million (1873 ...

in 1992 when Sabin was 86. A year later, Sabin died in Washington, D.C., from heart failure.

Medical career

Sabin trained in internal medicine, pathology, and surgery at

Bellevue Hospital Bellevue Hospital (officially NYC Health + Hospitals/Bellevue and formerly known as Bellevue Hospital Center) is a hospital in New York City and the oldest public hospital in the United States. One of the largest hospitals in the United States ...

in New York City from 1931 to 1933. In 1934, he conducted research at The Lister Institute for Preventive Medicine in England, then joined the Rockefeller Institute for Medical Research (now

Rockefeller University The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classif ...

). During this time, he developed an intense interest in research, especially in the area of

infectious diseases An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable di ...

. In 1939, he moved to Cincinnati Children's Hospital in

Cincinnati, Ohio Cincinnati ( ) is a city in the U.S. state of Ohio and the county seat of Hamilton County. Settled in 1788, the city is located at the northern side of the confluence of the Licking and Ohio rivers, the latter of which marks the state line w ...

. During World War II, he was a lieutenant colonel in the

U.S. Army Medical Corps The Medical Corps (MC) of the U.S. Army is a staff corps (non-combat specialty branch) of the U.S. Army Medical Department (AMEDD) consisting of commissioned medical officers – physicians with either an M.D. or a D.O. degree, at least one ...

and helped develop a vaccine against

Japanese encephalitis Japanese encephalitis (JE) is an infection of the brain caused by the Japanese encephalitis virus (JEV). While most infections result in little or no symptoms, occasional inflammation of the brain occurs. In these cases, symptoms may include he ...

. Maintaining his association with Children's Hospital, by 1946, he had also become the head of Pediatric Research at the

University of Cincinnati The University of Cincinnati (UC or Cincinnati) is a public research university in Cincinnati, Ohio. Founded in 1819 as Cincinnati College, it is the oldest institution of higher education in Cincinnati and has an annual enrollment of over 44,0 ...

. At Cincinnati's Children's Hospital, Sabin supervised the

fellowship A fellow is a concept whose exact meaning depends on context. In learned or professional societies, it refers to a privileged member who is specially elected in recognition of their work and achievements. Within the context of higher educatio ...

Robert M. Chanock Robert Merritt Chanock (July 8, 1924 – July 30, 2010) was an American pediatrician and virologist who made major contributions to the prevention and treatment of childhood respiratory infections in more than 50 years spent at the National Instit ...

, whom he called his "star scientific son."Brown, Emma
"Robert M. Chanock, virologist who studied children's diseases, dies at 86"
''

The Washington Post ''The Washington Post'' (also known as the ''Post'' and, informally, ''WaPo'') is an American daily newspaper published in Washington, D.C. It is the most widely circulated newspaper within the Washington metropolitan area and has a large n ...

'', August 4, 2010. Accessed August 9, 2010. Sabin went on a fact-finding trip to Cuba in 1967 to discuss with Cuban officials the possibility of establishing a collaborative relationship between the United States and Cuba through their respective national academies of sciences, in spite of the fact that the two countries did not have formal diplomatic ties. In 1969–72, he lived in

Israel Israel (; he, יִשְׂרָאֵל, ; ar, إِسْرَائِيل, ), officially the State of Israel ( he, מְדִינַת יִשְׂרָאֵל, label=none, translit=Medīnat Yīsrāʾēl; ), is a country in Western Asia. It is situated ...

, serving as President of

Rehovot Rehovot ( he, רְחוֹבוֹת ''Rəḥōvōt'', ar, رحوڤوت ''Reḥūfūt'') is a city in the Central District of Israel, about south of Tel Aviv. In it had a population of . Etymology Israel Belkind, founder of the Bilu movement, ...

. After his return to the United States, he worked (1974–82) as a research professor at the Medical University of South Carolina. He later moved to Washington, D.C. area, where he was a resident scholar at the John E. Fogarty International Center on the NIH campus in

Bethesda, Maryland Bethesda () is an unincorporated, census-designated place in southern Montgomery County, Maryland. It is located just northwest of Washington, D.C. It takes its name from a local church, the Bethesda Meeting House (1820, rebuilt 1849), which ...

Polio research

With the menace of polio growing, Sabin and other researchers, most notably Jonas Salk in

Pittsburgh Pittsburgh ( ) is a city in the Commonwealth (U.S. state), Commonwealth of Pennsylvania, United States, and the county seat of Allegheny County, Pennsylvania, Allegheny County. It is the most populous city in both Allegheny County and Wester ...

and Hilary Koprowski and H. R. Cox in

New York City New York, often called New York City or NYC, is the List of United States cities by population, most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the L ...

and

Philadelphia Philadelphia, often called Philly, is the largest city in the Commonwealth of Pennsylvania, the sixth-largest city in the U.S., the second-largest city in both the Northeast megalopolis and Mid-Atlantic regions after New York City. Since ...

, sought a vaccine to prevent or mitigate the illness. This was complicated because there were multiple strains of the disease. In 1951, the

National Foundation for Infantile Paralysis March of Dimes is a United States nonprofit organization that works to improve the health of mothers and babies. The organization was founded by President Franklin D. Roosevelt in 1938, as the National Foundation for Infantile Paralysis, to comba ...

's typing program confirmed the existence of three main

serotypes A serotype or serovar is a distinct variation within a species of bacteria or virus or among immune cells of different individuals. These microorganisms, viruses, or cells are classified together based on their surface antigens, allowing the ep ...

of poliovirus, since known as type 1, type 2, and type 3. Salk developed an inactivated poliovirus vaccine (IPV), a "dead" vaccine given by injection, which was released for use in 1955. It was effective in preventing most of the complications of polio, but did not prevent the initial intestinal infection. By carrying out autopsies of polio victims, Sabin was able to demonstrate that the poliovirus multiplied and attacked the intestines before it moved to the central nervous system. This also suggested that polio virus could be grown in other tissues besides embryonic brain tissue, leading to easier and cheaper methods of vaccine development.

John Enders John Franklin Enders (February 10, 1897 – September 8, 1985) was an American biomedical scientist and Nobel Laureate. Enders has been called "The Father of Modern Vaccines." Life and education Enders was born in West Hartford, Connecticut on Fe ...

, Thomas Huckle Weller, and

Frederick Robbins Frederick Chapman Robbins (August 25, 1916 – August 4, 2003) was an American pediatrician and virologist. He was born in Auburn, Alabama, and grew up in Columbia, Missouri, attending David H. Hickman High School. He received the Nobel Prize in P ...

would successfully grow poliovirus in laboratory cultures of non-nerve tissue in 1949, an achievement that earned them the 1954

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accordi ...

. Sabin developed an oral vaccine based on mutant strains of polio virus that seemed to stimulate antibody production but not to cause paralysis. Recipients of his live attenuated oral vaccine included himself, family, and colleagues. Sabin's first clinical trials were carried out at the Chillicothe Ohio Reformatory in late 1954. From 1956–1960, he worked with Russian colleagues to perfect the oral vaccine and prove its extraordinary effectiveness and safety. The Sabin vaccine worked in the intestines to block the poliovirus from entering the bloodstream. Between 1955 and 1961, the oral vaccine was tested on at least 100 million people in the USSR, parts of Eastern Europe, Singapore, Mexico, and the Netherlands. The first industrial production and mass use of oral poliovirus vaccine (OPV) from Sabin strains was organized by Soviet scientist Mikhail Chumakov. This provided the critical impetus for allowing large-scale clinical trials of OPV in the United States in April 1960 on 180,000 Cincinnati school children. The mass immunization techniques that Sabin pioneered with his associates effectively eradicated polio in Cincinnati. Against considerable opposition from the

March of Dimes March of Dimes is a United States nonprofit organization that works to improve the health of mothers and babies. The organization was founded by President Franklin D. Roosevelt in 1938, as the National Foundation for Infantile Paralysis, to comb ...

Foundation, which supported use of Salk's relatively effective killed vaccine, Sabin prevailed on the Public Health Service (PHS) to license his three strains of vaccine. While the PHS stalled, the USSR sent millions of doses of the oral vaccine to places with polio epidemics, such as Japan, and reaped the humanitarian benefit. Indeed, it was not clear to many that the vaccine was an American one, financed by U.S. dollars, as it was not widely available to ordinary Americans. Sabin's first oral poliovirus vaccine (OPV), for use against type 1 polioviruses, was licensed in the United States in 1961. His vaccines for type 2 and type 3 polioviruses were licensed in 1962. At first, the monovalent poliovirus vaccines were administered together by being put on a sugar cube. In 1964, a single trivalent OPV containing all three viral serotypes was approved. Sabin's oral vaccine was easier to give than the earlier vaccine developed by Salk in 1954, and its effects lasted longer. The Sabin vaccine became the predominant method of vaccination against polio in the United States for the next three decades. It broke the chain of transmission of the virus and allowed for the possibility that polio might one day be eradicated. Sabin also developed vaccines against other viral diseases, including

encephalitis Encephalitis is inflammation of the brain. The severity can be variable with symptoms including reduction or alteration in consciousness, headache, fever, confusion, a stiff neck, and vomiting. Complications may include seizures, hallucinations ...

and

dengue Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic ...

. In addition, he investigated possible links between viruses and some forms of

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...

.needs references

Philanthropy

Sabin refused to patent his vaccine, waiving commercial exploitation by pharmaceutical industries, so that the low price would guarantee a more extensive spread of the treatment. From the development of his vaccine Sabin did not gain a penny, and continued to live on his salary as a professor. The

Sabin Vaccine Institute Sabin Vaccine Institute (Sabin), located in Washington, D.C., is a nonprofit organization promoting global vaccine development, availability, and use. Through its work, Sabin hopes to reduce human suffering by preventing the spread of vaccine-pre ...

was founded in 1993 to continue the work of developing and promoting vaccines. To commemorate Sabin's pioneering work, the institute annually awards the

Albert B. Sabin Gold Medal Since 1994, the Albert B. Sabin Gold Medal has been awarded annually by the Sabin Vaccine Institute in recognition of work in the field of vaccinology or a complementary field. It is in commemoration of the pioneering work of Albert B. Sabin. Rec ...

in recognition of work in the field of

vaccinology A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. The safety and effectiveness of vaccines has been widely studied and verified.

or a complementary field.

Awards and recognition

* For the trivalent oral vaccine consisting of attenuated strains of all three types of the poliovirus, the president of the Supreme Soviet of the USSR awarded the highest civilian honour, the medal of the Order of Friendship Among Peoples (1986). * Election to the Polio Hall of Fame, which was dedicated in Warm Springs, Georgia, on January 2, 1958 *

Howard Taylor Ricketts Howard Taylor Ricketts (February 9, 1871 – May 3, 1910) was an American pathologist after whom the family Rickettsiaceae and the order Rickettsiales are named. He was born in Findlay, Ohio. In the early part of his career, Ricketts undertoo ...

Prize (1959) *

Robert Koch Prize The Robert Koch Medal and Award are two prizes awarded annually by the German for excellence in the biomedical sciences. These awards grew out of early attempts by German physician Robert Koch to generate funding to support his research into the ...

(1962) * Feltrinelli Prize (1964) * Lasker-DeBakey Clinical Medical Research Award (1965) *

National Medal of Science The National Medal of Science is an honor bestowed by the President of the United States to individuals in science and engineering who have made important contributions to the advancement of knowledge in the fields of behavioral and social scienc ...

(1970) *

Medal of Liberty The Medal of Liberty was awarded in 1986 by President Ronald Reagan as part of the festivities commemorating the 100th anniversary of the Statue of Liberty (''Liberty Enlightening the World''). The awarding of this medal took place only once, as i ...

(1986) *

Presidential Medal of Freedom The Presidential Medal of Freedom is the highest civilian award of the United States, along with the Congressional Gold Medal. It is an award bestowed by the president of the United States to recognize people who have made "an especially merit ...

(1986) *The Cincinnati Convention Center was named after Sabin from 1985 to 2006. *In 1999,

Cincinnati Children's Hospital Medical Center Cincinnati Children's Hospital Medical Center (CCHMC) is an academic pediatric acute care children's hospital located in the Pill Hill neighborhood of Cincinnati, Ohio. The hospital has 652 pediatric beds and is affiliated with the University ...

named its new education and conference center for Sabin. *The street that runs between the University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center was renamed Albert Sabin Way on April 28, 2000. *On March 6, 2006, the U.S. Postal Service issued an 87-cent

postage stamp A postage stamp is a small piece of paper issued by a post office, postal administration, or other authorized vendors to customers who pay postage (the cost involved in moving, insuring, or registering mail), who then affix the stamp to the f ...

bearing his image, in its Distinguished Americans series. *In early 2010, Sabin was proposed by the Ohio Historical Society as a finalist in a statewide vote for inclusion in Statuary Hall at the

United States Capitol The United States Capitol, often called The Capitol or the Capitol Building, is the seat of the legislative branch of the United States federal government, which is formally known as the United States Congress. It is located on Capitol Hill ...

. *In 2012, Albert Sabin was named a "Great Ohioan" by the Capitol Square Foundation.

References

;Notes ;Bibliography * * * * * * * * * * * * * * * *

External links

* ttps://www.nytimes.com/learning/general/onthisday/bday/0826.html Obituary, NY Times, March 4, 1993
Sabin Vaccine Institute

Hauck Center for the Albert B. Sabin Archives, University of Cincinnati

The Albert B. Sabin Digitization Project Blog, University of Cincinnati

The Albert B. Sabin Archives Digital Collection, University of Cincinnati

The Finding Aid for the Albert B. Sabin Papers, University of Cincinnati
{{DEFAULTSORT:Sabin, Albert 1906 births 1993 deaths American medical researchers American people of Polish-Jewish descent American pathologists American virologists Jews and Judaism in Cincinnati Jewish American scientists United States Army personnel of World War II National Medal of Science laureates People from Białystok People from Belostoksky Uyezd Polish emigrants to the United States Jews from the Russian Empire Polio Presidents of Weizmann Institute of Science New York University Grossman School of Medicine alumni University of Cincinnati faculty United States Army Medical Corps officers Vaccinologists Recipients of the Lasker-DeBakey Clinical Medical Research Award Presidential Medal of Freedom recipients Burials at Arlington National Cemetery Presidents of universities in Israel 20th-century American Jews Bellevue Hospital physicians