Adolf Butenandt
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Adolf Friedrich Johann Butenandt (; 24 March 1903 – 18 January 1995) was a German
biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and cell parts. The word "biochemist" is a portmanteau of "biological ch ...
. He was awarded the
Nobel Prize in Chemistry ) , image = Nobel Prize.png , alt = A golden medallion with an embossed image of a bearded man facing left in profile. To the left of the man is the text "ALFR•" then "NOBEL", and on the right, the text (smaller) "NAT•" then "M ...
in 1939 for his "work on sex hormones." He initially rejected the award in accordance with government policy, but accepted it in 1949 after
World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the World War II by country, vast majority of the world's countries—including all of the great power ...
. He was President of the
Max Planck Society The Max Planck Society for the Advancement of Science (german: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V.; abbreviated MPG) is a formally independent non-governmental and non-profit association of German research institutes. ...
from 1960 to 1972. He was also the first, in 1959, to discover the structure of the sex pheromone of silkworms which he named as
bombykol Bombykol is a pheromone released by the female silkworm moth to attract mates. It is also the sex pheromone in the wild silk moth (''Bombyx mandarina''). Discovered by Adolf Butenandt in 1959, it was the first pheromone to be characterized chemi ...
.


Biography

Born in Lehe, near
Bremerhaven Bremerhaven (, , Low German: ''Bremerhoben'') is a city at the seaport of the Free Hanseatic City of Bremen, a state of the Federal Republic of Germany. It forms a semi-enclave in the state of Lower Saxony and is located at the mouth of the Riv ...
, he started his studies at the
University of Marburg The Philipps University of Marburg (german: Philipps-Universität Marburg) was founded in 1527 by Philip I, Landgrave of Hesse, which makes it one of Germany's oldest universities and the oldest still operating Protestant university in the wor ...
. For his
PhD PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * '' Piled Higher and Deeper'', a web comic * Ph.D. (band), a 1980s British group ** Ph.D. (Ph.D. al ...
he joined the working group of the Nobel laureate Adolf Windaus at the
University of Göttingen The University of Göttingen, officially the Georg August University of Göttingen, (german: Georg-August-Universität Göttingen, known informally as Georgia Augusta) is a public research university in the city of Göttingen, Germany. Founded ...
and he finished his studies with a
PhD PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * '' Piled Higher and Deeper'', a web comic * Ph.D. (band), a 1980s British group ** Ph.D. (Ph.D. al ...
in chemistry in 1927. His doctoral research was on the chemistry of the insecticidal toxin found in the roots of '' Derris elliptica'' which he isolated and characterized. After his
Habilitation Habilitation is the highest university degree, or the procedure by which it is achieved, in many European countries. The candidate fulfills a university's set criteria of excellence in research, teaching and further education, usually including ...
he became lecturer in
Göttingen Göttingen (, , ; nds, Chöttingen) is a university city in Lower Saxony, central Germany, the capital of the eponymous district. The River Leine runs through it. At the end of 2019, the population was 118,911. General information The ori ...
1931. He became a professor ordinarius at the Technical University of Danzig 1933–1936. In 1933 Butenandt signed the ''
Vow of allegiance of the Professors of the German Universities and High-Schools to Adolf Hitler and the National Socialistic State Bekenntnis der Professoren an den Universitäten und Hochschulen zu Adolf Hitler und dem nationalsozialistischen Staat officially translated into English as the Vow of allegiance of the Professors of the German Universities and High-Schools to Ad ...
''. In 1936 he applied for the directorship of the Kaiser Wilhelm Institut (later the Max Planck Institute for Biochemistry) in Berlin-Dahlem while also joining the
NSDAP The Nazi Party, officially the National Socialist German Workers' Party (german: Nationalsozialistische Deutsche Arbeiterpartei or NSDAP), was a far-right political party in Germany active between 1920 and 1945 that created and supported t ...
on 1 May 1936 (party member No. 3716562). The earlier director of the Kaiser Wilhelm institute was Carl Neuberg, who had been removed for being a
Jew Jews ( he, יְהוּדִים, , ) or Jewish people are an ethnoreligious group and nation originating from the Israelites Israelite origins and kingdom: "The first act in the long drama of Jewish history is the age of the Israelites""T ...
. His work on rotenones was considered useful by the Nazi leadership as it could be useful for controlling lice among soldiers in the trenches. As the head of a leading institute, he applied for government funding on concentrated research labeled ''kriegswichtig'' (important for the war), some of which focused on military projects like the improvement of oxygen uptake for high-altitude bomber pilots. Adolf Windaus and Walter Schöller of Schering gave him the advice to work on hormones extracted from
ovaries The ovary is an organ in the female reproductive system that produces an ovum. When released, this travels down the fallopian tube into the uterus, where it may become fertilized by a sperm. There is an ovary () found on each side of the body. T ...
. This research lead to the discovery of estrone and other primary female
sex hormone Sex hormones, also known as sex steroids, gonadocorticoids and gonadal steroids, are steroid hormones that interact with vertebrate steroid hormone receptors. The sex hormones include the androgens, estrogens, and progestogens. Their effect ...
s, which were extracted from several thousand liters of
urine Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excreted from the body through the urethra. Cellul ...
. While working as professor in Danzig at the ''Chemisches Institut'' he was continuing his works over hormones extracting
progesterone Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the majo ...
in 1934 and
testosterone Testosterone is the primary sex hormone and anabolic steroid in males. In humans, testosterone plays a key role in the development of male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristi ...
a year later, the research results were along with the synthesis of steroids by
Leopold Ružička Leopold Ružička (; born Lavoslav Stjepan Ružička; 13 September 1887 – 26 September 1976) was a Croatian-Swiss scientist and joint winner of the 1939 Nobel Prize in Chemistry "for his work on polymethylenes and higher terpenes" "including t ...
considered significant enough to be awarded later by Nobel Committee in 1939. In 1940 he was involved in research on a hormone treatment to make long submarine voyages more comfortable for submariners in the Kriegsmarine. Butenand's involvement with the Nazi regime and various themes of research led to criticism after the war, and even after his death the exact nature of his political orientation during the Nazi era has never been fully resolved. When the institute moved to
Tübingen Tübingen (, , Swabian: ''Dibenga'') is a traditional university city in central Baden-Württemberg, Germany. It is situated south of the state capital, Stuttgart, and developed on both sides of the Neckar and Ammer rivers. about one in three ...
in 1945 he became a professor at the
University of Tübingen The University of Tübingen, officially the Eberhard Karl University of Tübingen (german: Eberhard Karls Universität Tübingen; la, Universitas Eberhardina Carolina), is a public research university located in the city of Tübingen, Baden-W ...
. In 1956, when the institute relocated to Martinsried, a suburb of
Munich Munich ( ; german: München ; bar, Minga ) is the capital and most populous city of the German state of Bavaria. With a population of 1,558,395 inhabitants as of 31 July 2020, it is the third-largest city in Germany, after Berlin and ...
, Butenandt became a professor at the
University of Munich The Ludwig Maximilian University of Munich (simply University of Munich or LMU; german: Ludwig-Maximilians-Universität München) is a public research university in Munich, Germany. It is Germany's sixth-oldest university in continuous operatio ...
. He also served as president of the
Max Planck Society for the Advancement of Science The Max Planck Society for the Advancement of Science (german: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V.; abbreviated MPG) is a formally independent non-governmental and non-profit association of German research institutes. ...
following
Otto Hahn Otto Hahn (; 8 March 1879 – 28 July 1968) was a German chemist who was a pioneer in the fields of radioactivity and radiochemistry. He is referred to as the father of nuclear chemistry and father of nuclear fission. Hahn and Lise Meitner ...
from 1960 to 1972. Butenandt is credited with the discovery and naming of the
silkworm The domestic silk moth (''Bombyx mori''), is an insect from the moth family Bombycidae. It is the closest relative of '' Bombyx mandarina'', the wild silk moth. The silkworm is the larva or caterpillar of a silk moth. It is an economically ...
moth pheromone
Bombykol Bombykol is a pheromone released by the female silkworm moth to attract mates. It is also the sex pheromone in the wild silk moth (''Bombyx mandarina''). Discovered by Adolf Butenandt in 1959, it was the first pheromone to be characterized chemi ...
in 1959. Butenandt died in
Munich Munich ( ; german: München ; bar, Minga ) is the capital and most populous city of the German state of Bavaria. With a population of 1,558,395 inhabitants as of 31 July 2020, it is the third-largest city in Germany, after Berlin and ...
in 1995, at the age of 91. His wife Erika, born in 1906, died in 1995 at 88.


Honours and awards

* 1939:
Nobel Prize in Chemistry ) , image = Nobel Prize.png , alt = A golden medallion with an embossed image of a bearded man facing left in profile. To the left of the man is the text "ALFR•" then "NOBEL", and on the right, the text (smaller) "NAT•" then "M ...
(shared with
Leopold Ruzicka Leopold may refer to: People * Leopold (given name) * Leopold (surname) Arts, entertainment, and media Fictional characters * Leopold (''The Simpsons''), Superintendent Chalmers' assistant on ''The Simpsons'' * Leopold Bloom, the protagonist ...
) for the identification of the sex hormones,
oestrogen Estrogen or oestrogen is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal activ ...
,
progesterone Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the majo ...
and
androsterone Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. It is a weak androgen with a potency that is approximately 1/7 that of testosterone. Androsterone is a metabolite of tes ...
* 1942:
War Merit Cross The War Merit Cross (german: Kriegsverdienstkreuz) was a state decoration of Nazi Germany during World War II. By the end of the conflict it was issued in four degrees and had an equivalent civil award. A " de-Nazified" version of the War Meri ...
, Second Class (Germany) *1943:
War Merit Cross The War Merit Cross (german: Kriegsverdienstkreuz) was a state decoration of Nazi Germany during World War II. By the end of the conflict it was issued in four degrees and had an equivalent civil award. A " de-Nazified" version of the War Meri ...
, First Class (Germany) * 1953:
Paul Ehrlich and Ludwig Darmstaedter Prize The Paul Ehrlich and Ludwig Darmstaedter Prize is an annual award bestowed by the since 1952 for investigations in medicine. It carries a prize money of 120,000 Euro. The prize awarding ceremony is traditionally held on March 14, the birthday of N ...
* 1959: Grand Merit Cross with Star and Sash of the Federal Republic of Germany (1959 and 1964) * 1960: Honorary Citizen of the City of
Bremerhaven Bremerhaven (, , Low German: ''Bremerhoben'') is a city at the seaport of the Free Hanseatic City of Bremen, a state of the Federal Republic of Germany. It forms a semi-enclave in the state of Lower Saxony and is located at the mouth of the Riv ...
* 1961: Wilhelm Normann Medal of the German Society for Fat Research * 1962: Bavarian Order of Merit * 1962:
Pour le Mérite The ' (; , ) is an order of merit (german: Verdienstorden) established in 1740 by King Frederick II of Prussia. The was awarded as both a military and civil honour and ranked, along with the Order of the Black Eagle, the Order of the Red Eag ...
* 1964:
Austrian Decoration for Science and Art The Austrian Decoration for Science and Art (german: Österreichisches Ehrenzeichen für Wissenschaft und Kunst) is a state decoration of the Republic of Austria and forms part of the Austrian national honours system. History The "Austrian ...
* 1967: Cultural Award of the City of
Munich Munich ( ; german: München ; bar, Minga ) is the capital and most populous city of the German state of Bavaria. With a population of 1,558,395 inhabitants as of 31 July 2020, it is the third-largest city in Germany, after Berlin and ...
* 1969: Commander of the French
Legion of Honour The National Order of the Legion of Honour (french: Ordre national de la Légion d'honneur), formerly the Royal Order of the Legion of Honour ('), is the highest French order of merit, both military and civil. Established in 1802 by Napoleo ...
* 1972:
Ordre des Palmes Académiques A suite, in Western classical music and jazz, is an ordered set of instrumental or orchestral/ concert band pieces. It originated in the late 14th century as a pairing of dance tunes and grew in scope to comprise up to five dances, sometimes w ...
* 1981:
Bavarian Maximilian Order for Science and Art The Bavarian Maximilian Order for Science and Art (german: Bayerischer Maximiliansorden für Wissenschaft und Kunst, links=no) was first established on 28 November 1853 by King Maximilian II von Bayern. It is awarded to acknowledge and reward exc ...
* 1985: Grand Cross of Merit of the Federal Republic of Germany * 1985: Honorary Citizen of the City of
Munich Munich ( ; german: München ; bar, Minga ) is the capital and most populous city of the German state of Bavaria. With a population of 1,558,395 inhabitants as of 31 July 2020, it is the third-largest city in Germany, after Berlin and ...
* 1994:
Grand Gold Decoration for Services to the Republic of Austria The Decoration of Honour for Services to the Republic of Austria (german: Ehrenzeichen für Verdienste um die Republik Österreich) is a state decoration of the Republic of Austria. It is divided into 15 classes and is the highest award in the A ...
* 1951 - 1992: 31 participations in the Lindau Nobel Laureate Meetings (record) * Honorary President of the
Max Planck Society The Max Planck Society for the Advancement of Science (german: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V.; abbreviated MPG) is a formally independent non-governmental and non-profit association of German research institutes. ...
* Honorary Doctor of Medicine (MD H.C.) * Honorary Doctor of Veterinary Medicine (Dr. med.vet. H.C.) * Honorary Doctor of Science (Dr. rer. Hc) * Honorary Doctor of Philosophy (Dr. phil. H.C.) * Honorary Doctor of Science (D.Sc.),
University of Leeds , mottoeng = And knowledge will be increased , established = 1831 – Leeds School of Medicine1874 – Yorkshire College of Science1884 - Yorkshire College1887 – affiliated to the federal Victoria University1904 – University of Leeds , ...
, 1961 * Honorary Doctor of Engineering (Dr.-Ing. E.h.)


See also

*
Androsterone Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. It is a weak androgen with a potency that is approximately 1/7 that of testosterone. Androsterone is a metabolite of tes ...
* Conjugated estriol * Epiandrosterone *
Pregnenolone Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous steroid and precursor/metabolic intermediate in the biosynthesis of most of the steroid hormones, including the progestogens, androgens, estrogens, glucocorticoids, and mineralocor ...


References


Bibliography

* *


External links

*
1939 Nobel Prize in Chemistry

Biography

MPG Biography
* Lindau Nobel Laureate Meetings
Background information on and historical lectures by Adolf Butenandt (mediatheque)
{{DEFAULTSORT:Butenandt, Adolf 1903 births 1995 deaths People from Bremerhaven Nazi Party members German biochemists University of Göttingen alumni University of Göttingen faculty University of Marburg alumni Humboldt University of Berlin faculty University of Tübingen faculty Ludwig Maximilian University of Munich faculty Gdańsk University of Technology faculty Max Planck Society people Members of the Prussian Academy of Sciences Members of the German Academy of Sciences at Berlin Members of the Bavarian Academy of Sciences Foreign Members of the Royal Society Members of the French Academy of Sciences German Nobel laureates Nobel laureates in Chemistry Grand Crosses 1st class of the Order of Merit of the Federal Republic of Germany Recipients of the Pour le Mérite (civil class) Recipients of the Austrian Decoration for Science and Art Commandeurs of the Légion d'honneur Recipients of the Grand Decoration for Services to the Republic of Austria