Aceclidine (Glaucostat, Glaunorm, Glaudin) is a
parasympathomimetic
A parasympathomimetic drug, sometimes called a cholinomimetic drug or cholinergic receptor stimulating agent, is a substance that stimulates the parasympathetic nervous system (PSNS). These chemicals are also called cholinergic drugs because ace ...
miotic agent used in the treatment of narrow angle
glaucoma
Glaucoma is a group of eye diseases that result in damage to the optic nerve (or retina) and cause vision loss. The most common type is open-angle (wide angle, chronic simple) glaucoma, in which the drainage angle for fluid within the eye rem ...
. It decreases
intraocular pressure
Intraocular pressure (IOP) is the fluid pressure inside the eye. Tonometry is the method eye care professionals use to determine this. IOP is an important aspect in the evaluation of patients at risk of glaucoma. Most tonometers are calibrated t ...
.
Adverse effects
Side effects of aceclidine include increased salivation and
bradycardia (in excessive doses).
Mechanism of action
Aceclidine acts as a
muscarinic acetylcholine receptor
Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells. They play several roles, including acting as the main end-rec ...
agonist.
See also
*
Talsaclidine (drug with a similar structure)
*
Muscarine
Muscarine, L-(+)-muscarine, or muscarin is a natural product found in certain mushrooms, particularly in '' Inocybe'' and '' Clitocybe'' species, such as the deadly '' C. dealbata''. Mushrooms in the genera '' Entoloma'' and ''Mycena'' have ...
References
{{Muscarinic acetylcholine receptor modulators
Acetate esters
Muscarinic agonists
Ophthalmology drugs
3-Quinuclidinyl esters
Drugs in the Soviet Union
Soviet inventions