AM-906 (part of the
AM cannabinoid series) is an
analgesic
An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...
drug which is a
cannabinoid agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
. It is conformationally restricted by virtue of the double bond on its side chain, leading an increased affinity for and selectivity between
CB1 and
CB2 receptors.
It is a potent and selective agonist for the CB
1 cannabinoid
receptor
Receptor may refer to:
* Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse
*Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...
, with a
''K''i of 0.8 nM at CB
1 and 9.5 nM at CB
2, a selectivity of almost 12x.
The corresponding ''E'' or
trans isomer is
AM-905.
See also
*
AM-1235
AM-1235 (1-(5-fluoropentyl)-3-(naphthalen-1-oyl)-6-nitroindole) is a drug that acts as a potent and reasonably selective agonist for the cannabinoid receptor CB1.
Pharmacology
Pharmacodynamics
AM-1235 is a cannabinoid receptor agonist with Ki ...
*
AM-2389
References
Benzochromenes
Primary alcohols
Phenols
AM cannabinoids
{{cannabinoid-stub