AB-001 (1-pentyl-3-(1-adamantoyl)indole) is a
designer drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. D ...
that was found as an ingredient in
synthetic cannabis smoking blends in Ireland in 2010 and Hungary and Germany in 2011.
It is unclear who AB-001 was originally developed by, but it is structurally related to compounds such as
AM-1248
AM-1248 is a drug that acts as a moderately potent agonist for both the cannabinoid receptors CB1 and CB2, but with some dispute between sources over its exact potency and selectivity. Replacing the 3-(1-naphthoyl) group found in many indole de ...
and its corresponding 1-(tetrahydropyran-4-ylmethyl) analogue, which are known to be potent cannabinoid agonists with moderate to high selectivity for
CB2 over
CB1.
[
] The first published synthesis and pharmacological evaluation of AB-001 revealed that it acts as a full agonist at CB1 (EC
50 = 35 nM) and CB2 receptors (EC
50 = 48 nM).
However, AB-001 was found to possess only weak cannabimimetic effects in rats at doses up to 30 mg/kg, making it less potent than the carboxamide analogue
APICA, which possesses potent cannabimimetic activity at doses of 3 mg/kg.
See also
*
A-834,735
A-834,735 is a drug developed by Abbott Laboratories that acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors, with a ''K''i of 12 nM at CB1 and 0.21 nM at CB2. Replacing the aromatic 3-benzoyl or 3- ...
*
AB-005
AB-005 or -[(1-methylpiperidin-2-yl)methyl1''H''-indol-3-yl">1-methylpiperidin-2-yl)methyl.html" ;"title="-[(1-methylpiperidin-2-yl)methyl">-[(1-methylpiperidin-2-yl)methyl1''H''-indol-3-yl2,2,3,3-tetramethylcyclopropyl)-methanone is a designer ...
*
AM-1248
AM-1248 is a drug that acts as a moderately potent agonist for both the cannabinoid receptors CB1 and CB2, but with some dispute between sources over its exact potency and selectivity. Replacing the 3-(1-naphthoyl) group found in many indole de ...
*
APICA
* JWH-018
* JWH-250
* RCS-4
* RCS-8
* MN-25
* UR-144
* Structural scheduling of synthetic cannabinoids
* Adamantane
References
{{Cannabinoids
Cannabinoids
Designer drugs
Adamantanoylindoles