A. Dale Kaiser
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Armin Dale Kaiser (November 10, 1927 – June 5, 2020) was an American biochemist, molecular geneticist, molecular biologist and developmental biologist.


Biography

Kaiser received in 1950 his bachelor's degree from
Purdue University Purdue University is a public land-grant research university in West Lafayette, Indiana, and the flagship campus of the Purdue University system. The university was founded in 1869 after Lafayette businessman John Purdue donated land and ...
and in 1955 his PhD from
Caltech The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...
in biology. At Caltech he was in
Max Delbrück Max Ludwig Henning Delbrück (; September 4, 1906 – March 9, 1981) was a German–American biophysicist who participated in launching the molecular biology research program in the late 1930s. He stimulated physical scientists' interest int ...
's bacteriophage group and received his PhD in biology under
Jean Weigle Jean-Jacques Weigle (9 July 1901 – 28 December 1968) was a Swiss molecular biologist at Caltech and formerly a physicist at the University of Geneva from 1931 to 1948. He is known for his major contributions on field of bacteriophage λ research, ...
with thesis ''A genetic analysis of bacteriophage lambda''. Kaiser was in 1956 a postdoc at the
Pasteur Institute The Pasteur Institute (french: Institut Pasteur) is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vacc ...
in Paris (where he worked in Francois Jacob's group) and afterward became an instructor and then in 1958 an assistant professor in microbiology at Washington University in St. Louis. In 1959 he became an assistant professor at
Stanford University Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is conside ...
, where in 1966 he became a professor for biochemistry at
Stanford University School of Medicine Stanford University School of Medicine is the medical school of Stanford University and is located in Stanford, California. It traces its roots to the Medical Department of the University of the Pacific, founded in San Francisco in 1858. This ...
. From 1989-2020 he was also a professor of developmental biology. In the beginning of his career, Kaiser concentrated on the molecular genetics of
bacteriophage lambda ''Enterobacteria phage λ'' (lambda phage, coliphage λ, officially ''Escherichia virus Lambda'') is a bacterial virus, or bacteriophage, that infects the bacterial species ''Escherichia coli'' (''E. coli''). It was discovered by Esther Leder ...
. He was especially concerned with the control mechanisms for lysogeny. He found one of the first examples of self-regulation of a gene ( ''cI'', the repressor gene of lambda phage) and later did pioneering work on
molecular chaperones In molecular biology, molecular chaperones are proteins that assist the conformational folding or unfolding of large proteins or macromolecular protein complexes. There are a number of classes of molecular chaperones, all of which function to ass ...
. Some of the methods developed by Kaiser's laboratory became important in genetic engineering. In the 1970s he worked on the developmental biology of swarms of
myxobacteria The myxobacteria ("slime bacteria") are a group of bacteria that predominantly live in the soil and feed on insoluble organic substances. The myxobacteria have very large genomes relative to other bacteria, e.g. 9–10 million nucleotides except ...
. In the 2000s his laboratory team did research on genetic and biochemical methods to control the swarm and propagation behavior of the bacterial species ''
Myxococcus xanthus ''Myxococcus xanthus'' is a gram-negative, rod-shaped species of myxobacteria that exhibits various forms of self-organizing behavior in response to environmental cues. Under normal conditions with abundant food, it exists as a predatory, sapro ...
''. When starved, the ''Myxococcus'' bacteria aggregate together to make fruiting bodies, each with approximately 10^5 spores; the form of the fruiting body is species-specific. Kaiser's laboratory succeeded in the identification and molecular elucidation of the roles of a series of molecular messengers in the swarm and propagation behavior of ''Myxococcus''.A. Dale Kaiser, National Academy of Sciences
/ref> Kaiser received in 1970 the U. S. Steel Foundation Award in Molecular Biology, in 1980 the
Albert Lasker Award for Basic Medical Research The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Medicine; almost 50 ...
, in 1981 the Waterford Biomedical Science Award, in 1997 the Abbott Lifetime Achievement Award of the
American Society for Microbiology The American Society for Microbiology (ASM), originally the Society of American Bacteriologists, is a professional organization for scientists who study viruses, bacteria, fungi, algae, and protozoa as well as other aspects of microbiology. It wa ...
and in 1991 the
Thomas Hunt Morgan Medal The Thomas Hunt Morgan Medal is awarded by the Genetics Society of America (GSA) for lifetime contributions to the field of genetics. The medal is named after Thomas Hunt Morgan, the 1933 Nobel Prize winner, who received this award for his work wi ...
. In 1970 he was elected a member of the
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nat ...
and a member of the
American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...
. In 1993 Kaiser was the president of the
Genetics Society of America The Genetics Society of America (GSA) is a scholarly membership society of more than 5,500 genetics researchers and educators, established in 1931. The Society was formed from the reorganization of the Joint Genetics Sections of the American Soci ...
. Born in
Piqua, Ohio Piqua ( ) is a city in Miami County, southwest Ohio, United States, 27 miles north of Dayton. The population was 20,522 at the 2010 census. It is part of the Dayton Metropolitan Statistical Area. It was founded as the village of Washington in ...
, Kaiser died in
Stanford, California Stanford is a census-designated place (CDP) in the northwest corner of Santa Clara County, California, United States. It is the home of Stanford University. The population was 21,150 at the 2020 census. Stanford is an unincorporated area of ...
.


Selected works

* Editor with Martin Dworkin ''Myxobacteria II'', American Society of Microbiology 1993 * Editor with Graham C. Walker ''Frontiers in Microbiology'', American Society of Microbiology 1993


References


External links


Official bio at Stanford University

Guide to the Armin Dale Kaiser Papers, Online Archive of California

search on author Dale Kaiser
from
Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines. Released in beta in November 2004, the Google Scholar index includes ...
{{DEFAULTSORT:Kaiser, A. Dale 1927 births 2020 deaths American biochemists American microbiologists Developmental biologists Purdue University alumni California Institute of Technology alumni Washington University in St. Louis faculty Stanford University faculty Members of the United States National Academy of Sciences Recipients of the Albert Lasker Award for Basic Medical Research People from Piqua, Ohio Scientists from Ohio