A-372159 is a drug which acts as a potent and selective
partial agonist for the
5HT2C receptor
Receptor may refer to:
* Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse
*Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...
, with more than 100x selectivity over the closely related
5-HT2B receptor and a
Ki of 3nM. It has been found to produce
anorectic effects in animal studies and produced significant weight loss in rats with no development of tolerance or serious side effects.
References
Serotonin receptor agonists
4-Hydroxybiphenyl ethers
Trifluoromethyl compounds
Piperidines
Cyclic ethers
Isopropyl compounds
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