AMDA (9-Aminomethyl-9,10-dihydroanthracene) is an

organic compound In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. The ...

which acts as a potent and selective

antagonist An antagonist is a character in a story who is presented as the chief foe of the protagonist. Etymology The English word antagonist comes from the Greek ἀνταγωνιστής – ''antagonistēs'', "opponent, competitor, villain, enemy, riv ...

for the 5-HT_2A

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

. It has been used to help study the shape of the 5-HT_2A protein, and develop a large family of related derivatives with even higher potency and selectivity.

Synthesis

It is synthesized from

9,10-Dihydroanthracene 9,10-Dihydroanthracene is an organic compound that is derived from the polycyclic aromatic hydrocarbon anthracene. Several isomers of dihydroanthracene are known, but the 9,10 derivative is most common. It is a colourless solid that is used as ...

. First one prepares the amide that is directly analogous to Cyheptamide 199-29-3or to Citenamide 0423-37-7 The last step in the synthesis is reduction of the amide functional group with Borane-tetrahydrofuran.

References

5-HT2A antagonists Phenethylamines Anthracenes {{Amine-stub

Synthesis

See also

References