5-MeO-DET or 5-methoxy-''N,N''-diethyltryptamine is a
hallucinogenic
Hallucinogens are a large, diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Most hallucinogens can be categorize ...
tryptamine
Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. The chemical structure is defined by an indole ─ a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the f ...
.
Pharmacology
5-MeO-DET inhibits
serotonin
Serotonin () or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex and multifaceted, modulating mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vas ...
reuptake with an IC
50 value of 2.4 μM and activates
5-HT2A receptors with an EC
50 value of 8.11 nM.
Effects
Low dosages (0.5–1 mg) are reported to produce a relaxing body high and mild
entheogen
Entheogens are psychoactive substances that induce alterations in perception, mood (psychology), mood, consciousness, cognition, or behavior for the purposes of engendering spiritual development or otherwiseRätsch, Christian, ''The Encyclop ...
ic effects.
Shulgin Shulgin (russian: Шульгин) is a Russian masculine surname, its feminine counterpart is Shulgina. It may refer to
* Alexander Shulgin (1925–2014), American pharmacologist and drug developer
**Shulgin Rating Scale
* Alexander Shulgin (musici ...
reports in
TiHKAL
''TIHKAL: The Continuation'' is a 1997 book written by Alexander Shulgin and Ann Shulgin about a family of psychoactive drugs known as tryptamines. A sequel to '' PIHKAL: A Chemical Love Story'', ''TIHKAL'' is an acronym that stands for "Tryp ...
that higher dosages (1–3 mg) can produce very unpleasant reactions.
See also
*
5-MeO-DiPT
*
5-MeO-DMT
5-MeO-DMT (5-methoxy-''N'',''N''-dimethyltryptamine) or O-methyl-bufotenin is a psychedelic of the tryptamine class. It is found in a wide variety of plant species, and also is secreted by the glands of at least one toad species, the Colorado Ri ...
*
5-MeO-MiPT
5-MeO-MiPT is a psychedelic and hallucinogenic drug, used by some as an entheogen. It has structural and pharmacodynamic properties similar to the drugs 5-MeO-DiPT, DiPT, and MiPT. It is commonly used as a "substitute" for 5-MeO-DiPT because o ...
*
TiHKAL
''TIHKAL: The Continuation'' is a 1997 book written by Alexander Shulgin and Ann Shulgin about a family of psychoactive drugs known as tryptamines. A sequel to '' PIHKAL: A Chemical Love Story'', ''TIHKAL'' is an acronym that stands for "Tryp ...
References
External links
TiHKAL entry #365-MeO-DET entry in TiHKAL • info
Psychedelic tryptamines
Designer drugs
Diethylamino compounds
{{hallucinogen-stub