4-HO-MPMI (also known as 4-Hydroxy-''N''-methyl-(α,''N''-trimethylene)-tryptamine or lucigenol) is a

tryptamine Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. The chemical structure is defined by an indole ─ a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the f ...

derivative In mathematics, the derivative of a function of a real variable measures the sensitivity to change of the function value (output value) with respect to a change in its argument (input value). Derivatives are a fundamental tool of calculus. ...

that is a psychedelic drug. It was developed by the team led by David Nichols from

Purdue University Purdue University is a public land-grant research university in West Lafayette, Indiana, and the flagship campus of the Purdue University system. The university was founded in 1869 after Lafayette businessman John Purdue donated land and mone ...

in the late 1990s. This compound produces hallucinogen-appropriate responding in animal tests with a similar potency to the amphetamine- derived psychedelic DOI, and has two enantiomers, with only the (''R'')-enantiomer being active. The binding affinity for 5-HT2A receptor is 13 ± 2 nM (Ki 25IOI). It is reported at doses starting at 0.5 mg and 1.0-1.5 mg seem to be psychedelic doses. The duration it is reported between six and eight hours. The effects, still not too documented, are OEV/CEV, sedation and anxiety.

References

{{DEFAULTSORT:4-HO-MPMI Psychedelic tryptamines Designer drugs

See also

References