4-Fluorophenibut (developmental code name CGP-11130; also known as β-(4-fluorophenyl)-γ-aminobutyric acid or β-(4-fluorophenyl)-GABA) is a GABA_B receptor agonist which was never marketed. It is selective for the GABA_B receptor over the GABA_A receptor ( IC₅₀ = 1.70 μM and > 100 μM, respectively). The drug is a

GABA analogue A GABA analogue is a compound which is an analogue or derivative of the neurotransmitter gamma-Aminobutyric acid (GABA) (the IUPAC of which is 4-aminobutanoic acid). Many GABA analogues are used as drugs, especially as anticonvulsants, sedative ...

and is closely related to

baclofen Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity such as from a spinal cord injury or multiple sclerosis. It may also be used for hiccups and muscle spasms near the end of life. It is ta ...

(β-(4-chlorophenyl)-GABA), tolibut (β-(4-methylphenyl)-GABA), and phenibut (β-phenyl-GABA). It is less potent as a GABA_B receptor agonist than baclofen but more potent than phenibut. The substance is sometimes referred to as 4F-phenibut or F-phenibut and colloquially as fluorobut.

Legal status

F-Phenibut is a prohibited substance in Lithuania and Hungary.MAGYARORSZÁG HIVATALOS LAPJA
Retrieved 2021-04-28.

References

Amines Carboxylic acids Experimental drugs Fluoroarenes GABA analogues GABAB receptor agonists {{Nervous-system-drug-stub