3-Deazaneplanocin A (DZNep, C-c3Ado) is a drug which acts as both a
''S''-adenosylhomocysteine synthesis inhibitor and also a
histone methyltransferase EZH2
Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme ( EC 2.1.1.43) encoded by gene, that participates in histone methylation and, ultimately, transcriptional repression. EZH2 catalyzes the addition of methyl groups ...
inhibitor. Studies have shown that it has ''
in vitro
''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called " test-tube experiments", these studies in biology ...
'' against a variety of different tumor
cell lines.
In studies on mice, the drug was also found to be effective for the treatment of
Ebola virus disease, apparently interfering with the Ebola viruses ability to block
interferon production, thus restoring the ability of immune system to rid the body of ebolavirus.
References
{{DEFAULTSORT:Deazaneplanocin A, 3-
Nucleosides
Imidazopyridines
Polyols
Experimental drugs
Cyclopentenes