25I-NBF (2C-I-NBF, NBF-2C-I, Cimbi-21) is a derivative of the

phenethylamine Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace am ...

hallucinogen Hallucinogens are a large, diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Most hallucinogens can be categorize ...

2C-I, which acts as a highly potent

partial agonist In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonis ...

for the

human Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, cultu ...

5-HT_2A

receptor Receptor may refer to: *Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a n ...

, with bias towards the β-arrestin 2 coupled signalling pathway. It has been studied in its ¹¹C radiolabelled form as a potential ligand for mapping the distribution of 5-HT_2A receptors in the brain, using

positron emission tomography Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, ...

(PET).

Legality

25I-NBF is illegal in Hungary, Japan, Latvia, and Vermont.

Sweden

The Riksdag added 25I-NBF to Narcotic Drugs Punishments Act under ''Swedish schedule I'' (''"substances, plant materials and fungi which normally do not have medical use"'') as of January 26, 2016, published by Medical Products Agency (MPA) in regulation ''HSLF-FS 2015:35'' listed as 25I-NBF, and 2-(4-jodo-2,5-dimetoxifenyl)-N-(2-fluorobensyl)etanamin.

United Kingdom

Analogues and derivatives

References

{{Phenethylamines 25-NB (psychedelics) Designer drugs Fluoroarenes Iodoarenes