25I-NB34MD (NB34MD-2C-I) is a derivative of the phenethylamine

hallucinogen Hallucinogens are a large, diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Most hallucinogens can be categorize ...

2C-I 2C-I is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin and described in his 1991 book '' PiHKAL'' (''Phenethylamines I Have Known and Loved''). The drug has been used recreationally as psychedelic and ...

, which acts as a potent

partial agonist In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonis ...

for the

human Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, cultu ...

5-HT_2A

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

, and presumably has similar properties to 2C-I. It has a

binding affinity In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from ''ligare'', which means 'to bind'. In protein-ligand binding, the ligand is usually a m ...

of 0.67nM at the human 5-HT_2A receptor, making it several times weaker than its

positional isomer In chemistry, a structural isomer (or constitutional isomer in the IUPAC nomenclature) of a compound is another compound whose molecule has the same number of atoms of each element, but with logically distinct bonds between them. The term meta ...

25I-NBMD 25I-NBMD (NBMD-2C-I, Cimbi-29) is a derivative of the phenethylamine hallucinogen 2C-I, discovered in 2006 by a team at Purdue University led by David Nichols. It acts as a potent partial agonist for the 5HT2A receptor Receptor may refer to: ...

and a similar potency to 25I-NBF.

Legality

Hungary

Illegal.

Japan

Illegal.

Sweden

The Riksdag added 25I-NB34MD to Narcotic Drugs Punishments Act under ''Swedish schedule I'' (''"substances, plant materials and fungi which normally do not have medical use"'') as of June 9, 2015, published by Medical Products Agency (MPA) in regulation ''LVFS 2015:4'' listed as 25I-NB34MD, and 2-(4-jodo-2,5-dimetoxifenyl)-N- 3,4-metylendioxifenyl)metyltanamin.

United Kingdom

Analogues and derivatives

References

{{Phenethylamines Benzodioxoles Designer drugs Iodoarenes 2C (psychedelics)