2,5-Dimethoxy-4-trifluoromethylamphetamine (DOTFM) is a
psychedelic drug of the
phenethylamine and
amphetamine chemical class Chemical classification systems attempt to classify elements or compounds according to certain chemical functional or structural properties. Whereas the structural properties are largely intrinsic, functional properties and the derived classificat ...
es. It was first
synthesized in 1994 by a team at
Purdue University
Purdue University is a public land-grant research university in West Lafayette, Indiana, and the flagship campus of the Purdue University system. The university was founded in 1869 after Lafayette businessman John Purdue donated land and mone ...
led by
David E. Nichols.
DOTFM is the
alpha-
methylated
analogue of
2C-TFM
2C-TFM is a psychedelic phenethylamine of the 2C family. It was first synthesized in the laboratory of David E. Nichols. It has also been called 2C-CF3, a name derived from the Para-trifluoromethyl group it contains.
Chemistry
2C-TFM is a c ...
, and is around twice as potent in animal studies. It acts as an
agonist at the
5HT2A and
5HT2C receptor
Receptor may refer to:
* Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse
*Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...
s.
In drug-substitution experiments in rats, DOTFM fully substituted for
LSD
Lysergic acid diethylamide (LSD), also known colloquially as acid, is a potent psychedelic drug. Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages LSD manifests primarily mental, vi ...
and was slightly more potent than
DOI.
See also
*
DOx
References
{{DEFAULTSORT:Dimethoxy-4-trifluoromethylamphetamine, 2,5-
Substituted amphetamines
Trifluoromethyl compounds
2,5-Dimethoxyphenethylamines
Substances discovered in the 1990s