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Tamtuvetmab
Tamtuvetmab (AT-005) (INN, trade name Tactress) is a veterinary monoclonal antibody.[1][2] This drug was developed by Aratana Therapeutics. References[edit]^ Statement On A Nonproprietary Name Adopted By The USAN Council - Tamtuvetmab, American Medical Association. ^ World Health Organization
World Health Organization
(2015). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 114" (PDF). WHO Drug Information
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American Medical Association
The American Medical Association
American Medical Association
(AMA), founded in 1847 and incorporated in 1897,[3] is the largest association of physicians—both MDs and DOs—and medical students in the United States.[4] The AMA's stated mission is "to bring together physicians and communities to improve the nation’s health."[5] The Association also publishes the Journal of the American Medical Association
American Medical Association
(JAMA), which has the largest circulation of any weekly medical journal in the world.[6] The AMA also publishes a list of Physician Specialty Codes which are the standard method in the U.S
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Ipilimumab
Ipilimumab
Ipilimumab
(trade name Yervoy) is a monoclonal antibody that works to activate the immune system by targeting CTLA-4, a protein receptor that downregulates the immune system. Cytotoxic T lymphocytes
Cytotoxic T lymphocytes
(CTLs) can recognize and destroy cancer cells. However, an inhibitory mechanism interrupts this destruction.[3] Ipilimumab
Ipilimumab
turns off this inhibitory mechanism and allows CTLs to function.[3][4] Ipilimumab
Ipilimumab
was approved by the U.S. FDA in 2011 for the treatment of melanoma, a type of skin cancer.[5][6] It is undergoing clinical trials for the treatment of non-small cell lung carcinoma (NSCLC), small cell lung cancer (SCLC),[7] bladder cancer[8] and metastatic hormone-refractory prostate cancer.[9] The concept of using anti-CTLA4 antibodies to treat cancer was first developed by James P. Allison
James P

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CD52
NM_001803n/aRefSeq (protein)NP_001794n/aLocation (UCSC) Chr 1: 26.32 – 26.32 Mb n/a PubMed
PubMed
search [2] n/aWikidataView/Edit HumanCAMPATH-1 antigen, also known as cluster of differentiation 52 (CD52), is a glycoprotein that in humans is encoded by the CD52
CD52
gene. CD52
CD52
is present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived. It also is found on monocytes[3] and dendritic cells.[4] Further, it is found within the male genital tract and is present on the surface of mature sperm cells. CD52
CD52
is a peptide of 12 amino acids, anchored to glycosylphosphatidylinositol (GPI)
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Anatomical Therapeutic Chemical Classification System
The Anatomical Therapeutic
Therapeutic
Chemical (ATC) Classification System
System
is used for the classification of active ingredients of drugs according to the organ or system on which they act and their therapeutic, pharmacological and chemical properties. It is controlled by the World Health Organization Collaborating Centre for Drug
Drug
Statistics Methodology (WHOCC), and was first published in 1976.[1] This pharmaceutical coding system divides drugs into different groups according to the organ or system on which they act or their therapeutic and chemical characteristics. Each bottom-level ATC code stands for a pharmaceutically used substance, or a combination of substances, in a single indication (or use)
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CAS Registry Number
A CAS Registry Number,[1] also referred to as CASRN or CAS Number, is a unique numerical identifier assigned by the Chemical Abstracts Service (CAS) to every chemical substance described in the open scientific literature (currently including all substances described from 1957 through the present, plus some substances from the early or mid 1900s), including organic and inorganic compounds, minerals, isotopes, alloys and nonstructurable materials (UVCBs, of unknown, variable composition, or biological origin).[2] The Registry maintained by CAS is an authoritative collection of disclosed chemical substance information. It currently identifies more than 129 million organic and inorganic substances and 67 million protein and DNA sequences,[3] plus additional information about each substance
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ChemSpider
ChemSpider
ChemSpider
is a database of chemicals. ChemSpider
ChemSpider
is owned by the Royal Society of Chemistry.[3][4][5][6][7][8][9][10][11][12][13]Contents1 Database 2 Crowdsourcing 3 Searching 4 Chemistry document mark-up 5 History 6 Services6.1 SyntheticPages 6.2 Open PHACTS7 See also 8 ReferencesDatabase[edit] The database contains information on more than 63 million molecules from over 280 data sources including:EPA DSSTox[14][15] U.S
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Unique Ingredient Identifier
The Unique Ingredient Identifier (UNII) is a non-proprietary, free, unique, unambiguous, non-semantic, alphanumeric identifier linked to a substance's molecular structure or descriptive information by the Substance Registration System (SRS) of the Food and Drug Administration (FDA) and the United States Pharmacopeia (USP). The SRS is used to generate permanent, unique identifiers for substances in regulated products, such as ingredients in drug and biologic products. The SRS uses molecular structure and descriptive information to define a substance and generate the UNII. The primary means for defining a substance is by its molecular structure as represented on a two-dimensional plane
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Chemical Formula
A chemical formula is a way of information about the chemical proportions of atoms that constitute a particular chemical compound or molecule, using chemical element symbols, numbers, and sometimes also other symbols, such as parentheses, dashes, brackets, commas and plus (+) and minus (−) signs. These are limited to a single typographic line of symbols, which may include subscripts and superscripts. A chemical formula is not a chemical name, and it contains no words. Although a chemical formula may imply certain simple chemical structures, it is not the same as a full chemical structural formula. Chemical formulas can fully specify the structure of only the simplest of molecules and chemical substances, and are generally more limited in power than are chemical names and structural formulas. The simplest types of chemical formulas are called empirical formulas, which use letters and numbers indicating the numerical proportions of atoms of each type
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Molar Mass
In chemistry, the molar mass M is a physical property defined as the mass of a given substance (chemical element or chemical compound) divided by the amount of substance.[1] The base SI unit
SI unit
for molar mass is kg/mol
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International Nonproprietary Name
The World Health Organization
World Health Organization
has a constitutional mandate to "develop, establish and promote international standards with respect to biological, pharmaceutical and similar products". The World Health Organization
World Health Organization
collaborates closely with INN experts and national nomenclature committees to select a single name of worldwide acceptability for each active substance that is to be marketed as a pharmaceutical
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World Health Organization
The World Health Organization
World Health Organization
(WHO) is a specialized agency of the United Nations
United Nations
that is concerned with international public health. It was established on 7 April 1948 headquartered in Geneva, Switzerland. The WHO
WHO
is a member of the United Nations
United Nations
Development Group. Its predecessor, the Health Organization, was an agency of the League of Nations. The constitution of the World Health Organization
World Health Organization
had been signed by 61 countries on 7 April 1948, with the first meeting of the World Health Assembly finishing on 24 July 1948. It incorporated the Office International d'Hygiène Publique and the League of Nations
League of Nations
Health Organization. Since its creation, it has played a leading role in the eradication of smallpox
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Neoplasm
Neoplasm
Neoplasm
is an abnormal growth of tissue which, if it forms a mass, is commonly referred to as a tumor.[1][2][3] This abnormal growth (neoplasia) usually (but not always) forms a mass.[4] ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior.[5] Malignant neoplasms
Malignant neoplasms
are also simply known as cancers and are the focus of oncology. Prior to the abnormal growth of tissue, as neoplasia, cells often undergo an abnormal pattern of growth, such as metaplasia or dysplasia.[6] However, metaplasia or dysplasia does not always progress to neoplasia.[1] The word is from Ancient Greek
Ancient Greek
νέος- neo "new" and πλάσμα plasma "formation, creation".Contents1 Types1.1 Clonality 1.2 Neoplasia
Neoplasia
vs
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Antigen
In immunology, an antigen is a molecule capable of inducing an immune response (to produce an antibody) in the host organism.[1] Sometimes antigens are part of the host itself in an autoimmune disease.[2] Antigens
Antigens
are "targeted" by antibodies. Each antibody (immune response) is specifically produced by the immune system to match an antigen after cells in the immune system come into contact with it; this allows a precise identification or matching of the antigen and the initiation of a tailored response. The antibody is said to "match" the antigen in the sense that it can bind to it due to an adaptation performed to a region of the antibody; because of this, many different antibodies are produced, each with specificity to bind a different antigen while sharing the same basic structure
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Olaratumab
Olaratumab
Olaratumab
(trade name Lartruvo) is a monoclonal antibody developed by Eli Lilly and Company
Eli Lilly and Company
for the treatment of solid tumors
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Ofatumumab
Ofatumumab[1] (trade name Arzerra, also known as HuMax-CD20) is a fully human monoclonal antibody (for the CD20
CD20
protein) which appears to inhibit early-stage B lymphocyte activation. It is FDA approved for treating chronic lymphocytic leukemia that is refractory to fludarabine and alemtuzumab (Campath) and has also shown potential in treating follicular lymphoma, diffuse large B cell lymphoma, rheumatoid arthritis and relapsing remitting multiple sclerosis. Ofatumumab
Ofatumumab
has also received conditional approval in Europe for the treatment of refractory chronic lymphocytic leukemia
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