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Parvalbumin
Parvalbumin (PV) is a calcium-binding protein with low molecular weight (typically 9-11 kDa). In humans, it is encoded by the ''PVALB'' gene. It is not a member of the albumin family; it is named for its size (''parv-'', from Latin ''parvus'' small) and its ability to coagulate. It has three EF hand motifs and is structurally related to calmodulin and troponin C. Parvalbumin is found in fast-contracting muscles, where its levels are highest, as well as in the brain and some endocrine tissues. Parvalbumin is a small, stable protein containing EF-hand type calcium binding sites. It is involved in calcium signaling. Typically, this protein is broken into three domains, domains AB, CD and EF, each individually containing a helix-loop-helix motif. The AB domain houses a two amino-acid deletion in the loop region, whereas domains CD and EF contain the N-terminal and C-terminal, respectively. Calcium binding proteins like parvalbumin play a role in many physiological processes, namely ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Traffic Signals
Traffic lights, traffic signals, or stoplights – known also as robots in South Africa are signalling devices positioned at road intersections, pedestrian crossings, and other locations in order to control flows of traffic. Traffic lights consist normally of three signals, transmitting meaningful information to drivers and riders through colours and symbols including arrows and bicycles. The regular traffic light colours are red, yellow, and green arranged vertically or horizontally in that order. Although this is internationally standardised,1968, as revised 1995 and 2006Vienna Convention on Road Signs and Signals United Nations Publication ECE/TRANS/196. ISBN 978-92-1-116973-7. URL Accessed: 7 January 2022. variations exist on national and local scales as to traffic light sequences and laws. The method was first introduced in December 1868 on Parliament Square in London to reduce the need for police officers to control traffic. Since then, electricity and computerised c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacovigilance
Term Given By Tushar Sharma (UPES Batch 2025) Pharmacovigilance (PV, or PhV), also known as drug safety, is the pharmaceutical science relating to the "collection, detection, assessment, monitoring, and prevention" of adverse effects with pharmaceutical products. The etymological roots for the word "pharmacovigilance" are: (Greek for drug) and (Latin for to keep watch). As such, pharmacovigilance heavily focuses on adverse drug reactions (ADR), which are defined as any response to a drug which is noxious and unintended, including lack of efficacy (the condition that this definition only applies with the doses normally used for the prophylaxis, diagnosis or therapy of disease, or for the modification of physiological disorder function was excluded with the latest amendment of the applicable legislation). Medication errors such as overdose, and misuse and abuse of a drug as well as drug exposure during pregnancy and breastfeeding, are also of interest, even without an adverse ev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paceville
Paceville ( sometimes abbreviated PV) is a district in St Julian's which is the main nightlife hub in Malta, being heavily populated with nightclubs, bars, stripclubs, pubs and restaurants, it is hence also known as 'Malta's Sin City'. Paceville is located between Spinola Point and Dragonara Point, delimiting Spinola Bay and St. George's Bay respectively. Paceville is seen as a party destination in Europe and is a popular place for locals and tourists alike. In 2016, it was estimated that Paceville's population stood around 1,939, of which 1,160 were foreigners. Origins Early years Paceville traces its origins in the 1910s and 1920s when prominent lawyer and developer Dr Giuseppe Pace (1890–1971) built a few seaside residence in the area of St. Julian's known as 'il-Qaliet', the small bay between the Dragonara Peninsula and Portomaso. Some of these residencies are still there today, although they are now surrounded by the multi-storey apartments and hotels in the area ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Periventricular Nucleus
The periventricular nucleus is a thin sheet of small neurons located in the wall of the third ventricle, a composite structure of the hypothalamus. It functions in analgesia. It is located in the rostral, intermediate, and caudal regions of the hypothalamus. The rostral region aids in the production of both somatostatin and thyroid releasing hormone. The intermediate portion aids in production of thyroid releasing hormone, somatostatin, leptin, gastrin, and neuropeptide y. In humans and primates it also produces GnRH. Lastly the caudal region aids in sympathetic nervous system regulation, and is regarded as the rage center. The periventricular nucleus does not have an effective blood–brain barrier. 11β-HSD2 expression turns cortisol into cortisone. Role in LH and GnRH release This nucleus has been shown to affect the release of GnRH (gonadotropin-releasing hormone) in several ways. One way is its expression of neuropeptide Y, which has an impact on the hypothalamic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Principal Value
In mathematics, specifically complex analysis, the principal values of a multivalued function are the values along one chosen branch of that function, so that it is single-valued. The simplest case arises in taking the square root of a positive real number. For example, 4 has two square roots: 2 and −2; of these the positive root, 2, is considered the principal root and is denoted as \sqrt. Motivation Consider the complex logarithm function log ''z''. It is defined as the complex number ''w'' such that :e^w = z. Now, for example, say we wish to find log ''i''. This means we want to solve :e^w = i for ''w''. Clearly ''i''π/2 is a solution. But is it the only solution? Of course, there are other solutions, which is evidenced by considering the position of ''i'' in the complex plane and in particular its argument arg ''i''. We can rotate counterclockwise π/2 radians from 1 to reach ''i'' initially, but if we rotate further another 2π we reach ''i'' again. S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paravirtualization
In computing, paravirtualization or para-virtualization is a virtualization technique that presents a software interface to the virtual machines which is similar, yet not identical, to the underlying hardware–software interface. The intent of the modified interface is to reduce the portion of the guest's execution time spent performing operations which are substantially more difficult to run in a virtual environment compared to a non-virtualized environment. The paravirtualization provides specially defined 'hooks' to allow the guest(s) and host to request and acknowledge these tasks, which would otherwise be executed in the virtual domain (where execution performance is worse). A successful paravirtualized platform may allow the virtual machine monitor (VMM) to be simpler (by relocating execution of critical tasks from the virtual domain to the host domain), and/or reduce the overall performance degradation of machine execution inside the virtual guest. Paravirtualization re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Semaphore (programming)
In computer science, a semaphore is a variable or abstract data type used to control access to a common resource by multiple threads and avoid critical section problems in a concurrent system such as a multitasking operating system. Semaphores are a type of synchronization primitive. A trivial semaphore is a plain variable that is changed (for example, incremented or decremented, or toggled) depending on programmer-defined conditions. A useful way to think of a semaphore as used in a real-world system is as a record of how many units of a particular resource are available, coupled with operations to adjust that record ''safely'' (i.e., to avoid race conditions) as units are acquired or become free, and, if necessary, wait until a unit of the resource becomes available. Semaphores are a useful tool in the prevention of race conditions; however, their use is not a guarantee that a program is free from these problems. Semaphores which allow an arbitrary resource count are c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Page View
In web analytics and website management, a pageview or page view, abbreviated in business to PV and occasionally called page impression, is a request to load a single HTML file ( web page) of an Internet site. On the World Wide Web, a page request would result from a web surfer clicking on a link on another page pointing to the page in question. In contrast, a hit refers to a request for any file from a web server. Therefore, there may be many hits per page view since an HTML page can contain multiple files such as images, videos, JavaScripts, CSS, cascading style sheets (CSS), etc. On balance, page views refer to a number of pages viewed or clicked on the site during the given time. Page views may be counted as part of web analytics. For the owner of the site, this information can be useful to see if any change in the "page" (such as the information or the way it is presented) results in more visits. If there are any advertisements on the page, the publishers would also be int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Perovskite
Perovskite (pronunciation: ) is a calcium titanium oxide mineral composed of calcium titanate (chemical formula ). Its name is also applied to the class of compounds which have the same type of crystal structure as (XIIA2+VIB4+X2−3), known as the perovskite structure. Many different cations can be embedded in this structure, allowing the development of diverse engineered materials. History The mineral was discovered in the Ural Mountains of Russia by Gustav Rose in 1839 and is named after Russian mineralogist Lev Perovski (1792–1856). Perovskite's notable crystal structure was first described by Victor Goldschmidt in 1926 in his work on tolerance factors. The crystal structure was later published in 1945 from X-ray diffraction data on barium titanate by Helen Dick Megaw. Occurrence Found in the Earth's mantle, perovskite's occurrence at Khibina Massif is restricted to the silica under-saturated ultramafic rocks and foidolites, due to the instability in a paragen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peroxide Value
Detection of peroxide gives the initial evidence of rancidity in unsaturated fats and oils. Other methods are available, but peroxide value is the most widely used. It gives a measure of the extent to which an oil sample has undergone primary oxidation, extent of secondary oxidation may be determined from p-anisidine test.Chemistry And Technology Of Oils And FatChemistry And Technology Of Oils And Fats By Dr. M.M. Chakrabarty The double bonds found in fats and oils play a role in autoxidation. Oils with a high degree of unsaturation are most susceptible to autoxidation. The best test for autoxidation (oxidative rancidity) is determination of the peroxide value. Peroxides are intermediates in the autoxidation reaction. Autoxidation is a free radical reaction involving oxygen that leads to deterioration of fats and oils which form off-flavours and off-odours. Peroxide value, concentration of peroxide in an oil or fat, is useful for assessing the extent to which spoilage has advanc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protecting Group
A protecting group or protective group is introduced into a molecule by chemical modification of a functional group to obtain chemoselectivity in a subsequent chemical reaction. It plays an important role in multistep organic synthesis. In many preparations of delicate organic compounds, some specific parts of their molecules cannot survive the required reagents or chemical environments. Then, these parts, or groups, must be protected. For example, lithium aluminium hydride is a highly reactive but useful reagent capable of reducing esters to alcohols. It will always react with carbonyl groups, and this cannot be discouraged by any means. When a reduction of an ester is required in the presence of a carbonyl, the attack of the hydride on the carbonyl has to be prevented. For example, the carbonyl is converted into an acetal, which does not react with hydrides. The acetal is then called a protecting group for the carbonyl. After the step involving the hydride is complete, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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