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Peter Walter
Peter Walter (born December 5, 1954) is a German-American molecular biologist and biochemist and is Director of the Bay Area Institute of Science at Altos Labs, Professor at the University of California, San Francisco (UCSF). He was a Howard Hughes Medical Institute (HHMI) Investigator until 2022. Education Peter attended the Freie Universität Berlin, received his MS in Organic Chemistry from Vanderbilt University in 1977 and his PhD in Cell Biology at The Rockefeller University in 1981. Career During his thesis work in Dr. Günter Blobel's laboratory, Walter purified the proteinaceous members of a macromolecular complex essential for protein translocation into the endoplasmic reticulum (ER) and showed that it selectively recognizes nascent secretory proteins in the cytoplasm of eukaryotic cells and targets them to the ER. He subsequently identified a 7S RNA component of the complex which is essential for its function and named the holocomplex the signal recognition particle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
West Berlin
West Berlin (german: Berlin (West) or , ) was a political enclave which comprised the western part of Berlin during the years of the Cold War. Although West Berlin was de jure not part of West Germany, lacked any sovereignty, and was under military occupation until German reunification in 1990, the territory was claimed by the Federal Republic of Germany (FRG) which was heavily disputed by the Soviet Union and other Eastern Bloc countries. However, West Berlin de facto aligned itself politically with the FRG on 23 May 1949, was directly or indirectly represented in its federal institutions, and most of its residents were citizens of the FRG. West Berlin was formally controlled by the Western Allies and entirely surrounded by the Soviet-controlled East Berlin and East Germany. West Berlin had great symbolic significance during the Cold War, as it was widely considered by westerners an "island of freedom" and America's most loyal counterpart in Europe. It was heavily subsidi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Vilcek Foundation
The Vilcek Foundation raises awareness of immigrant contributions to the United States, and fosters appreciation of the arts and sciences. The foundation's flagship programs include the Vilcek Foundation Prizes, which recognize and support immigrant contributions to American arts, biomedical science, and society. The foundation is also the designated steward of the art collection assembled by founders Jan and Marica Vilcek, comprising holdings in American modernism, Native American pottery, pre Columbian objects, and contemporary art. The Foundation was established in 2000 by Jan and Marica Vilcek, immigrants from the former Czechoslovakia. The mission of the Foundation was inspired by the couple's respective careers in biomedical science and art history, as well as their personal experiences and appreciation for the opportunities offered them as newcomers to the United States. Prizes Vilcek Prizes The Vilcek Prizes are awarded to foreign-born individuals residing permanently ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vilcek Foundation
The Vilcek Foundation raises awareness of immigrant contributions to the United States, and fosters appreciation of the arts and sciences. The foundation's flagship programs include the Vilcek Foundation Prizes, which recognize and support immigrant contributions to American arts, biomedical science, and society. The foundation is also the designated steward of the art collection assembled by founders Jan and Marica Vilcek, comprising holdings in American modernism, Native American pottery, pre Columbian objects, and contemporary art. The Foundation was established in 2000 by Jan and Marica Vilcek, immigrants from the former Czechoslovakia. The mission of the Foundation was inspired by the couple's respective careers in biomedical science and art history, as well as their personal experiences and appreciation for the opportunities offered them as newcomers to the United States. Prizes Vilcek Prizes The Vilcek Prizes are awarded to foreign-born individuals residing permanently ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Inventors
The National Academy of Inventors (NAI) is a US non-profit organization dedicated to encouraging inventors in academia, following the model of the National Academies of the United States. It was founded at the University of South Florida in 2010. Starting in 2012, the NAI has inducted 757 Fellows into the organization. Fellows must be named as an inventor on at least one US patent and are selected by the NAI Fellows Committee. The NAI also includes colleges and universities as institutional members, beginning with 9 such institutions in 2012; it now has over 200, including 30 outside the United States.. Since 2013, the National Academy of Inventors and the Intellectual Property Owners Association have released an annual report listing the top 100 universities by the number of US patents. The University of California has topped the list each year. The NAI has held a yearly national conference since 2011. In 2017, US Representative Dennis A. Ross introduced the bill HR 976, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Medicine
The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Sciences (NAS), National Academy of Engineering (NAE), and the National Research Council (NRC). The National Academy of Medicine provides national and international advice on issues relating to health, medicine, health policy, and biomedical science. It aims to provide unbiased, evidence-based, and authoritative information and advice concerning health and science policy to policy-makers, professionals, leaders in every sector of society, and the public at large. Operating outside the framework of the U.S. federal government, it relies on a volunteer workforce of scientists and other experts, operating under a formal peer-review system. As a national academy, the organization ann ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Academy Of Arts And Sciences
The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other Founding Fathers of the United States. It is headquartered in Cambridge, Massachusetts. Membership in the academy is achieved through a thorough petition, review, and election process. The academy's quarterly journal, '' Dædalus'', is published by MIT Press on behalf of the academy. The academy also conducts multidisciplinary public policy research. History The Academy was established by the Massachusetts legislature on May 4, 1780, charted in order "to cultivate every art and science which may tend to advance the interest, honor, dignity, and happiness of a free, independent, and virtuous people." The sixty-two incorporating fellows represented varying interests and high standing in the political, professional, and commercial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field. Members of the National Academy of Sciences serve ''pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Founded in 1863 as a result of an Act of Congress that was approved by Abraham Lincoln, the NAS is charged with "providing independent, objective advice to the nation on matters related to science and technology. ... to provide scien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Unfolded Protein Response
The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. It has been found to be conserved between all mammalian species, as well as yeast and worm organisms. The UPR is activated in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum. In this scenario, the UPR has three aims: initially to restore normal function of the cell by halting protein translation, degrading misfolded proteins, and activating the signalling pathways that lead to increasing the production of molecular chaperones involved in protein folding. If these objectives are not achieved within a certain time span or the disruption is prolonged, the UPR aims towards apoptosis. Sustained overactivation of the UPR has been implicated in prion diseases as well as several other neurodegenerative diseases, and inhibiting the UPR could become a treatment for those diseases. Diseases amenable to UPR inhibition inc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Signal Recognition Particle
The signal recognition particle (SRP) is an abundant, cytosolic, universally conserved ribonucleoprotein ( protein- RNA complex) that recognizes and targets specific proteins to the endoplasmic reticulum in eukaryotes and the plasma membrane in prokaryotes. History The function of SRP was discovered by the study of processed and unprocessed secretory proteins, particularly immunoglobulin light chains; and bovine preprolactin. Newly synthesized proteins in eukaryotes carry N-terminal hydrophobic Signal peptide, signal sequences, which are bound by SRP when they emerge from the ribosome. Mechanism In eukaryotes, SRP binds to the signal sequence of a newly synthesized peptide as it emerges from the ribosome. This binding leads to the slowing of protein synthesis known as "elongation arrest", a conserved function of SRP that facilitates the coupling of the protein translation and the protein translocation processes. SRP then targets this entire complex (the ribosome-n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endoplasmic Reticulum
The endoplasmic reticulum (ER) is, in essence, the transportation system of the eukaryotic cell, and has many other important functions such as protein folding. It is a type of organelle made up of two subunits – rough endoplasmic reticulum (RER), and smooth endoplasmic reticulum (SER). The endoplasmic reticulum is found in most eukaryotic cells and forms an interconnected network of flattened, membrane-enclosed sacs known as cisternae (in the RER), and tubular structures in the SER. The membranes of the ER are continuous with the outer nuclear membrane. The endoplasmic reticulum is not found in red blood cells, or spermatozoa. The two types of ER share many of the same proteins and engage in certain common activities such as the synthesis of certain lipids and cholesterol. Different types of cells contain different ratios of the two types of ER depending on the activities of the cell. RER is found mainly toward the nucleus of cell and SER towards the cell membrane or plasma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Howard Hughes Medical Institute
The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, film director, and philanthropist, known during his lifetime as one of the most financially successful individuals in the world. It is one of the largest private funding organizations for biological and medical research in the United States. HHMI spends about $1 million per HHMI Investigator per year, which amounts to annual investment in biomedical research of about $825 million. The institute has an endowment of $22.6 billion, making it the second-wealthiest philanthropic organization in the United States and the second-best endowed medical research foundation in the world. HHMI is the former owner of the Hughes Aircraft Company – an American aerospace firm which was divested to various firms over time. History The institute was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Altos Labs
Altos Labs, Inc. is an American biotechnology research company. Altos Labs' goal is to develop life extension therapies that can halt or reverse the human aging process. Specialized cell therapies based on induced pluripotent stem cells are to be developed for this purpose. The company was started in 2022. History Altos Labs was formally started on 19 January 2022. The name Altos Labs is based on the city of Los Altos in California. The idea for Altos Labs originated with cell biologist and entrepreneur Richard D. Klausner, who co-founded the company with Hans Bishop. One of the early investors of Altos Labs is an investment vehicle held for the benefit of the Breakthrough Foundation, founded by Russian-Israeli science and technology investor and philanthropist Yuri Milner and his wife Julia. The foundation supports existing and future philanthropic projects in fundamental sciences. Milner had previously shown interest in anti-aging technologies, in October 2020, he co- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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