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PHCCC
PHCCC
PHCCC
is a research drug which acts as a glutamate receptor ligand, particularly being a positive allosteric modulator at the mGluR4 subtype,[1] as well as an agonist at mGluR6.[2] It has anxiolytic effects in animal studies.[3] PHCCC
PHCCC
and similar drugs have been suggested as novel treatments for Parkinson's disease.[4] See also[edit]CPCCOEtReferences[edit]^ Maj M, Bruno V, Dragic Z, Yamamoto R, Battaglia G, Inderbitzin W, Stoehr N, Stein T, Gasparini F, Vranesic I, Kuhn R, Nicoletti F, Flor PJ (December 2003). "(−)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection". Neuropharmacology. 45 (7): 895–906. doi:10.1016/S0028-3908(03)00271-5. PMID 14573382.  ^ Beqollari D, Kammermeier PJ (July 2008). "The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors"
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IUPAC Nomenclature Of Chemistry
The International Union of Pure and Applied Chemistry
International Union of Pure and Applied Chemistry
(IUPAC) has published four sets of rules to standardize chemical nomenclature. There are two main areas: IUPAC nomenclature of inorganic chemistry
IUPAC nomenclature of inorganic chemistry
(Red Book) IUPAC nomenclature of organic chemistry
IUPAC nomenclature of organic chemistry
(Blue Book)This chemistry-related article is a stub
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Parkinson's Disease
Parkinson's disease
Parkinson's disease
(PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.[1] The symptoms generally come on slowly over time.[1] Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking.[1] Thinking and behavioral problems may also occur.[2]
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Chemical Formula
A chemical formula is a way of information about the chemical proportions of atoms that constitute a particular chemical compound or molecule, using chemical element symbols, numbers, and sometimes also other symbols, such as parentheses, dashes, brackets, commas and plus (+) and minus (−) signs. These are limited to a single typographic line of symbols, which may include subscripts and superscripts. A chemical formula is not a chemical name, and it contains no words. Although a chemical formula may imply certain simple chemical structures, it is not the same as a full chemical structural formula. Chemical formulas can fully specify the structure of only the simplest of molecules and chemical substances, and are generally more limited in power than are chemical names and structural formulas. The simplest types of chemical formulas are called empirical formulas, which use letters and numbers indicating the numerical proportions of atoms of each type
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PubMed Central
PubMed
PubMed
Central (PMC) is a free digital repository that archives publicly accessible full-text scholarly articles that have been published within the biomedical and life sciences journal literature. As one of the major research databases within the suite of resources that have been developed by the National Center for Biotechnology Information (NCBI), PubMed
PubMed
Central is much more than just a document repository
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PubMed Identifier
PubMed
PubMed
is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine
United States National Library of Medicine
(NLM) at the National Institutes of Health
National Institutes of Health
maintains the database as part of the Entrez
Entrez
system of information retrieval. From 1971 to 1997, MEDLINE online access to the MEDLARS Online computerized database primarily had been through institutional facilities, such as university libraries
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Digital Object Identifier
In computing, a Digital Object Identifier or DOI is a persistent identifier or handle used to uniquely identify objects, standardized by the International Organization for Standardization
International Organization for Standardization
(ISO).[1] An implementation of the Handle System,[2][3] DOIs are in wide use mainly to identify academic, professional, and government information, such as journal articles, research reports and data sets, and official publications though they also have been used to identify other types of information resources, such as commercial videos. A DOI aims to be "resolvable", usually to some form of access to the information object to which the DOI refers. This is achieved by binding the DOI to metadata about the object, such as a URL, indicating where the object can be found. Thus, by being actionable and interoperable, a DOI differs from identifiers such as ISBNs and ISRCs which aim only to uniquely identify their referents
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Positive Allosteric Modulator
In biochemistry and pharmacology, an allosteric modulator (allo- from the Greek meaning "other") is a substance which indirectly influences (modulates) the effects of a receptor agonist or inverse agonist at its receptor protein target. Allosteric modulators bind to a site distinct from that of the orthosteric binding site where a receptor agonist would normally bind. Usually they induce a conformational change within the protein structure. Positive allosteric modulators (PAMs), also known as allosteric enhancers, induce an amplification of the orthosteric agonist's effect, either by enhancing the binding affinity or the functional efficacy of the orthosteric agonist for the target protein.[1] Most benzodiazepines act as PAMs. Negative allosteric modulators (NAMs) reduce the effects of the orthosteric ligand, but is inactive in the absence of the orthosteric ligand
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Simplified Molecular-input Line-entry System
The simplified molecular-input line-entry system (SMILES) is a specification in form of a line notation for describing the structure of chemical species using short ASCII
ASCII
strings. SMILES strings can be imported by most molecule editors for conversion back into two-dimensional drawings or three-dimensional models of the molecules. The original SMILES specification was initiated in the 1980s. It has since been modified and extended. In 2007, an open standard called OpenSMILES was developed in the open-source chemistry community
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JSmol
Jmol
Jmol
is computer software for molecular modelling chemical structures in 3-dimensions.[2] Jmol
Jmol
returns a 3D representation of a molecule that may be used as a teaching tool,[3] or for research e.g., in chemistry and biochemistry. It is written in the programming language Java, so it can run on the operating systems Windows, macOS, Linux, and Unix, if Java is installed. It is free and open-source software released under a GNU Lesser General Public License
GNU Lesser General Public License
(LGPL) version 2.0. A standalone application and a software development kit (SDK) exist that can be integrated into other Java applications, such as Bioclipse and Taverna. A popular feature is an applet that can be integrated into web pages to display molecules in a variety of ways
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Molar Mass
In chemistry, the molar mass M is a physical property defined as the mass of a given substance (chemical element or chemical compound) divided by the amount of substance.[1] The base SI unit
SI unit
for molar mass is kg/mol
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Eglumegad
Eglumegad (LY354740) is a research drug developed by Eli Lilly and Company, which is being investigated for its potential in the treatment of anxiety[1] and drug addiction.[2] It is a glutamate derived compound and its mode of action implies a novel mechanism.[3]Contents1 Mechanism of action 2 Effects 3 Clinical development 4 See also 5 ReferencesMechanism of action[edit] Eglumegad acts as a group-selective agonist for the group II metabotropic glutamate receptors (mGluR2/3).[4][5] It is unclear whether eglumegad directly interacts with dopamine D2 receptors.[6][7] Effects[edit] In experiments on mice, eglumegad was found to be as effective as diazepam for treating anxiety symptoms in several standard tests, but without producing any of the negative side effects of diazepam such as sedation and memory impairment.[8] Tests in humans confirmed that it produced anxiolytic effects without producing sedation.[9][10] However it did slightly reduce cognitive performance i
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Fenobam
Fenobam
Fenobam
is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain
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Mavoglurant
Mavoglurant
Mavoglurant
(developmental code name AFQ-056) is an experimental drug candidate for the treatment of fragile X syndrome and other conditions which has been discontinued.[1][2] It exerts its effect as an antagonist of the metabotropic glutamate receptor 5 (mGluR5).[3] Mavoglurant
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Remeglurant
Remeglurant
Remeglurant
(INN; developmental code name MRZ-8456) is a drug which acts as a selective antagonist of the mGlu5 receptor.[1][2][3] It is under development by Merz Pharmaceuticals for the treatment of drug-induced dyskinesia but no development has been reported since at least 2016.[3] See also[edit]Basimglurant Dipraglurant Fenobam Mavoglurant RaseglurantReferences[edit]^ World Health Organization
World Health Organization
(2013). "International Nonproprietary Names for Pharmaceutical Substances (INN): Proposed INN: List 109" (PDF). WHO Drug
Drug
Information. World Health Organization. 27 (2).  ^ Danysz W, et al. Substituted pyrazolo[1,5-A]pyrimidines as metabotropic glutamate receptor modulators
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