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Myricetin
Myricetin is a member of the flavonoid class of polyphenolic compounds, with antioxidant properties. Common dietary sources include vegetables (including tomatoes), fruits (including oranges), nuts, berries, tea, and red wine. Myricetin is structurally similar to fisetin, luteolin, and quercetin and is reported to have many of the same functions as these other members of the flavonol class of flavonoids. Reported average intake of myricetin per day varies depending on diet, but has been shown in the Netherlands to average 23 mg/day. Myricetin is produced from the parent compound taxifolin through the (+)-dihydromyricetin intermediate and can be further processed to form laricitrin and then syringetin, both members of the flavonol class of flavonoids. Dihydromyricetin is frequently sold as a supplement and has controversial function as a partial GABAA receptor potentiator and treatment in Alcohol Use Disorder (AUD). Myricetin can alternatively be produced directly fro ...
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Ampelopsin
Ampelopsin, also known as dihydromyricetin and DHM, when purported as an effective ingredient in supplements and other tonics, is a flavanonol, a type of flavonoid. It is extracted from the Japanese raisin tree and found in ''Ampelopsis'' species ''japonica'', ''megalophylla'', and ''grossedentata''; ''Cercidiphyllum japonicum''; ''Hovenia dulcis''; '' Rhododendron cinnabarinum''; some ''Pinus'' species; and some ''Cedrus'' species, as well as in '' Salix sachalinensis''. ''Hovenia dulcis'' has been used in traditional Japanese, Chinese, and Korean medicines to treat fever, parasitic infection, as a laxative, and a treatment of liver diseases, and as a hangover treatment. Methods have been developed to extract ampelopsin on a larger scale, and laboratory research has been conducted with the compound to see if it might be useful as a drug in any of the conditions for which the parent plant has been traditionally used. Research Research suggests that DHM protects against DOX ...
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Laricitrin
Laricitrin is an ''O''-methylated flavonol, a type of flavonoid. It is found in red grape (absent in white grape) and in '' Vaccinium uliginosum'' (bog billberries). It is one of the phenolic compounds present in wine. Metabolism Laricitrin is formed from myricetin by the action of the enzyme myricetin O-methyltransferase. It is further methylated by laricitrin 5'-O-methyltransferase into syringetin. Glycosides * Laricitrin 3-O-galactoside, found in grape * Laricitrin 3-glucoside found in ''Larix sibirica'' * Laricitrin 3,5’-di-O-β-glucopyranoside, found in ''Medicago littoralis ''Medicago littoralis'' is a plant species of the genus ''Medicago''. It is found primarily in the Mediterranean basin. It forms a symbiotic relationship with the bacterium ''Sinorhizobium meliloti'', which is capable of nitrogen fixation Nitr ...''
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Syringetin
Syringetin is an ''O''-methylated flavonol, a type of flavonoid. It is found in red grape (absent in white grape), in ''Lysimachia congestiflora'' and in '' Vaccinium uliginosum'' (bog billberries). It is one of the phenolic compounds present in wine. It induces human osteoblast differentiation through bone morphogenetic protein-2/extracellular signal-regulated kinase 1/2 pathway. Metabolism Syringetin is formed from laricitrin by the action of the enzyme laricitrin 5′-''O''-methyltransferase ( myricetin ''O''-methyltransferase). Glycosides * Syringetin-3-''O''-galactoside * Syringetin-3-''O''-glucoside * Syringetin 3-rhamnoside (CAS number 93126-00-2) * Syringetin-3-''O''-rutinoside found in ''Larix sibirica'' * Syringetin 3-''O''-(6′′-acetyl)-β-glucopyranoside found in ''Picea abies ''Picea abies'', the Norway spruce or European spruce, is a species of spruce native to Northern, Central and Eastern Europe. It has branchlets that typically hang downwards, an ...
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Fisetin
Fisetin (7,3′,4′- flavon-3-ol) is a plant flavonol from the flavonoid group of polyphenols. It can be found in many plants, where it serves as a yellow/ochre colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions and cucumbers. Its chemical formula was first described by Austrian chemist Josef Herzig in 1891. The biological activity of fisetin has been studied in many laboratory assays; like other polyphenols it has many activities. Biological sources Fisetin can be found in a wide variety of plants. It is found in Eudicotyledons, such as trees and shrubs in the family Fabaceae, such as the acacias ''Acacia greggii'' and ''Acacia berlandieri'', the parrot tree (''Butea frondosa''), the honey locust (''Gleditsia triacanthos''), members of the family Anacardiaceae such as the '' Quebracho colorado'' and species of the genus ''Rhus'', which contains the sumacs. Along with myricetin, fisetin provides the color of the ...
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Blackcurrant
The blackcurrant (''Ribes nigrum''), also known as black currant or cassis, is a deciduous shrub in the family Grossulariaceae grown for its edible berries. It is native to temperate parts of central and northern Europe and northern Asia, where it prefers damp fertile soils. It is widely cultivated both commercially and domestically. It is winter hardy, but cold weather at flowering time during the spring may reduce the size of the crop. Bunches of small, glossy black fruit develop along the stems in the summer and can be harvested by hand or by machine. Breeding is common in Scotland, Poland, Lithuania, Latvia, Norway, and New Zealand to produce fruit with better eating qualities and bushes with greater hardiness and disease resistance. The raw fruit is particularly rich in vitamin C and polyphenols. Blackcurrants can be eaten raw but are usually cooked in sweet or savoury dishes. They are used to make jams, preserves, and syrups and are grown commercially for the juice mar ...
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Empetrum Nigrum
''Empetrum nigrum'', crowberry, black crowberry, or, in western Alaska, blackberry, is a flowering plant species in the heather family Ericaceae with a near circumboreal distribution in the Northern Hemisphere. It is usually dioecious, but there is a bisexual tetraploid subspecies, ''Empetrum nigrum'' subsp. ''hermaphroditum'', which occurs in more northerly locations and at higher altitude. Description ''Empetrum nigrum'' is a low growing, evergreen shrub with a creeping habit. The leaves are long, arranged alternately along the stem. The stems are red when young and then fade to brown. It blooms between May and June. The flowers are small and not very noticeable, with greenish-pink sepals that turn reddish purple. The round fruits are drupes, wide, usually black or purplish-black but occasionally red. The metabolism and photosynthetic parameters of ''Empetrum'' can be altered in winter-warming experiments. Subspecies * ''Empetrum nigrum'' subsp. ''asiaticum'' (Nak ...
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Vaccinium Virgatum
''Vaccinium virgatum'' (commonly known as rabbit-eye blueberry, smallflower blueberry or southern black blueberry ) is a species of blueberry native to the Southeastern United States, from North Carolina south to Florida and west to Texas. Description ''Vaccinium virgatum'' is a deciduous shrub growing to 3 to 6 feet tall and with up to a 3-foot spread. The leaves are spirally arranged, oblate to narrow elliptic, 3 inches long and start out red-bronze in the spring only to develop into a dark-green. The flowers are white, bell-shaped, 5 mm long. The fruit is a berry 5 mm diameter, dark blue to black, bloomed pale blue-gray by a thin wax coating. Pollination ''Vaccinium virgatum'' is self-infertile, and must have two or more varieties to pollenize each other. Honeybees are inefficient pollinators, and carpenter bees frequently cut the corollas to rob nectar without pollinating the flowers. ''V. virgatum'' does best when pollinated by buzz pollination by b ...
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Sweet Potato
The sweet potato or sweetpotato ('' Ipomoea batatas'') is a dicotyledonous plant that belongs to the bindweed or morning glory family, Convolvulaceae. Its large, starchy, sweet-tasting tuberous roots are used as a root vegetable. The young shoots and leaves are sometimes eaten as greens. Cultivars of the sweet potato have been bred to bear tubers with flesh and skin of various colors. Sweet potato is only distantly related to the common potato (''Solanum tuberosum''), both being in the order Solanales. Although darker sweet potatoes are often referred to as "yams" in parts of North America, the species is not a true yam, which are monocots in the order Dioscoreales. Sweet potato is native to the tropical regions of the Americas. Of the approximately 50 genera and more than 1,000 species of Convolvulaceae, ''I. batatas'' is the only crop plant of major importance—some others are used locally (e.g., ''I. aquatica'' "kangkong"), but many are poisonous. The genus ''I ...
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Antioxidants
Antioxidants are compounds that inhibit oxidation, a chemical reaction that can produce free radicals. This can lead to polymerization and other chain reactions. They are frequently added to industrial products, such as fuels and lubricants, to prevent oxidation, and to foods to prevent spoilage, in particular the rancidification of oils and fats. In cells, antioxidants such as glutathione, mycothiol or bacillithiol, and enzyme systems like superoxide dismutase, can prevent damage from oxidative stress. The only dietary antioxidants are vitamins A, C, and E, but the term ''antioxidant'' has also been applied to numerous other dietary compounds that only have antioxidant properties in vitro, with little evidence for antioxidant properties in vivo. Dietary supplements marketed as antioxidants have not been shown to maintain health or prevent disease in humans. History As part of their adaptation from marine life, terrestrial plants began producing non-marine antioxida ...
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Flavonoid
Flavonoids (or bioflavonoids; from the Latin word ''flavus'', meaning yellow, their color in nature) are a class of polyphenolic secondary metabolites found in plants, and thus commonly consumed in the diets of humans. Chemically, flavonoids have the general structure of a 15-carbon skeleton, which consists of two phenyl rings (A and B) and a heterocyclic ring (C, the ring containing the embedded oxygen). This carbon structure can be abbreviated C6-C3-C6. According to the IUPAC nomenclature, they can be classified into: *flavonoids or bioflavonoids * isoflavonoids, derived from 3-phenyl chromen-4-one (3-phenyl-1,4- benzopyrone) structure *neoflavonoids, derived from 4-phenyl coumarine (4-phenyl-1,2- benzopyrone) structure The three flavonoid classes above are all ketone-containing compounds and as such, anthoxanthins (flavones and flavonols). This class was the first to be termed bioflavonoids. The terms flavonoid and bioflavonoid have also been more loosely used to descri ...
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Cranberry
Cranberries are a group of evergreen dwarf shrubs or trailing vines in the subgenus ''Oxycoccus'' of the genus '' Vaccinium''. In Britain, cranberry may refer to the native species '' Vaccinium oxycoccos'', while in North America, cranberry may refer to '' Vaccinium macrocarpon''. ''Vaccinium oxycoccos'' is cultivated in central and northern Europe, while ''Vaccinium macrocarpon'' is cultivated throughout the northern United States, Canada and Chile. In some methods of classification, ''Oxycoccus'' is regarded as a genus in its own right. They can be found in acidic bogs throughout the cooler regions of the Northern Hemisphere. Cranberries are low, creeping shrubs or vines up to long and in height; they have slender, wiry stems that are not thickly woody and have small evergreen leaves. The flowers are dark pink, with very distinct ''reflexed'' petals, leaving the style and stamens fully exposed and pointing forward. They are pollinated by bees. The fruit is a berry that ...
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Reactive Oxygen Species
In chemistry, reactive oxygen species (ROS) are highly reactive chemicals formed from diatomic oxygen (). Examples of ROS include peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen. The reduction of molecular oxygen () produces superoxide (), which is the precursor to most other reactive oxygen species: :O2 + e^- -> \ ^\bullet O2- Dismutation of superoxide produces hydrogen peroxide (): :2 H+ + \ ^\bullet O2^- + \ ^\bullet O2^- -> H2O2 + O2 Hydrogen peroxide in turn may be partially reduced, thus forming hydroxide ions and hydroxyl radicals (), or fully reduced to water: :H2O2 + e^- -> HO^- + \ ^\bullet OH :2 H+ + 2 e- + H2O2 -> 2 H2O In a biological context, ROS are byproducts of the normal metabolism of oxygen. ROS have roles in cell signaling and homeostasis. ROS are intrinsic to cellular functioning, and are present at low and stationary levels in normal cells. In plants, ROS are involved in metabolic processes related to photoprotection and toleran ...
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