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Morphogenesis
Morphogenesis (from the Greek ''morphê'' shape and ''genesis'' creation, literally "the generation of form") is the biological process that causes a cell, tissue or organism to develop its shape. It is one of three fundamental aspects of developmental biology along with the control of tissue growth and patterning of cellular differentiation. The process controls the organized spatial distribution of cells during the embryonic development of an organism. Morphogenesis can take place also in a mature organism, such as in the normal maintenance of tissue by stem cells or in regeneration of tissues after damage. Cancer is an example of highly abnormal and pathological tissue morphogenesis. Morphogenesis also describes the development of unicellular life forms that do not have an embryonic stage in their life cycle. Morphogenesis is essential for the evolution of new forms. Morphogenesis is a mechanical process involving forces that generate mechanical stress, strain, and mov ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Developmental Biology
Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of regeneration, asexual reproduction, metamorphosis, and the growth and differentiation of stem cells in the adult organism. Perspectives The main processes involved in the embryonic development of animals are: tissue patterning (via regional specification and patterned cell differentiation); tissue growth; and tissue morphogenesis. * Regional specification refers to the processes that create the spatial patterns in a ball or sheet of initially similar cells. This generally involves the action of cytoplasmic determinants, located within parts of the fertilized egg, and of inductive signals emitted from signaling centers in the embryo. The early stages of regional specification do not generate functional differentiated cells, but cell populations committed to developing to a specific region or part of the organism. These a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Developmental Biology
Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of regeneration, asexual reproduction, metamorphosis, and the growth and differentiation of stem cells in the adult organism. Perspectives The main processes involved in the embryonic development of animals are: tissue patterning (via regional specification and patterned cell differentiation); tissue growth; and tissue morphogenesis. * Regional specification refers to the processes that create the spatial patterns in a ball or sheet of initially similar cells. This generally involves the action of cytoplasmic determinants, located within parts of the fertilized egg, and of inductive signals emitted from signaling centers in the embryo. The early stages of regional specification do not generate functional differentiated cells, but cell populations committed to developing to a specific region or part of the organism. These a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alan Turing
Alan Mathison Turing (; 23 June 1912 – 7 June 1954) was an English mathematician, computer scientist, logician, cryptanalyst, philosopher, and theoretical biologist. Turing was highly influential in the development of theoretical computer science, providing a formalisation of the concepts of algorithm and computation with the Turing machine, which can be considered a model of a general-purpose computer. He is widely considered to be the father of theoretical computer science and artificial intelligence. Born in Maida Vale, London, Turing was raised in southern England. He graduated at King's College, Cambridge, with a degree in mathematics. Whilst he was a fellow at Cambridge, he published a proof demonstrating that some purely mathematical yes–no questions can never be answered by computation and defined a Turing machine, and went on to prove that the halting problem for Turing machines is undecidable. In 1938, he obtained his PhD from the Department of M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Morphogen
A morphogen is a substance whose non-uniform distribution governs the pattern of tissue development in the process of morphogenesis or pattern formation, one of the core processes of developmental biology, establishing positions of the various specialized cell types within a tissue. More specifically, a morphogen is a signaling molecule that acts directly on cells to produce specific cellular responses depending on its local concentration. Typically, morphogens are produced by source cells and diffuse through surrounding tissues in an embryo during early development, such that concentration gradients are set up. These gradients drive the process of differentiation of unspecialised stem cells into different cell types, ultimately forming all the tissues and organs of the body. The control of morphogenesis is a central element in evolutionary developmental biology (evo-devo). History The term was coined by Alan Turing in the paper " The Chemical Basis of Morphogenesis", wher ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
D'Arcy Wentworth Thompson
Sir D'Arcy Wentworth Thompson CB FRS FRSE (2 May 1860 – 21 June 1948) was a Scottish biologist, mathematician and classics scholar. He was a pioneer of mathematical and theoretical biology Mathematical and theoretical biology, or biomathematics, is a branch of biology which employs theoretical analysis, mathematical models and abstractions of the living organisms to investigate the principles that govern the structure, development ..., travelled on expeditions to the Bering Strait and held the position of Professor of Natural History at University College, Dundee for 32 years, then at University of St Andrews, St Andrews for 31 years. He was elected a Fellow of the Royal Society, was Knight Bachelor, knighted, and received the Darwin Medal and the Daniel Giraud Elliot Medal. Thompson is remembered as the author of the 1917 book ''On Growth and Form'', which led the way for the scientific explanation of morphogenesis, the process by which Patterns in nature, patterns an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Chemical Basis Of Morphogenesis
"The Chemical Basis of Morphogenesis" is an article that the English mathematician Alan Turing wrote in 1952. It describes how patterns in nature, such as stripes and spirals, can arise naturally from a homogeneous, uniform state. The theory, which can be called a reaction–diffusion theory of morphogenesis, has become a basic model in theoretical biology. Such patterns have come to be known as Turing patterns. For example, it has been postulated that the protein VEGFC can form Turing patterns to govern the formation of lymphatic vessels in the zebrafish embryo. Reaction–diffusion systems Reaction–diffusion systems have attracted much interest as a prototype model for pattern formation. Patterns such as fronts, spirals, targets, hexagons, stripes and dissipative solitons are found in various types of reaction-diffusion systems in spite of large discrepancies e.g. in the local reaction terms. Such patterns have been dubbed " Turing patterns". Reaction–diffusion p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Regeneration (biology)
In biology, regeneration is the process of renewal, restoration, and tissue growth that makes genomes, cells, organisms, and ecosystems resilient to natural fluctuations or events that cause disturbance or damage. Every species is capable of regeneration, from bacteria to humans. Regeneration can either be complete where the new tissue is the same as the lost tissue, or incomplete where after the necrotic tissue comes fibrosis. At its most elementary level, regeneration is mediated by the molecular processes of gene regulation and involves the cellular processes of cell proliferation, morphogenesis and cell differentiation. Regeneration in biology, however, mainly refers to the morphogenic processes that characterize the phenotypic plasticity of traits allowing multi-cellular organisms to repair and maintain the integrity of their physiological and morphological states. Above the genetic level, regeneration is fundamentally regulated by asexual cellular processes. Regenera ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Patterns
Patterns in nature are visible regularities of form found in the natural world. These patterns recur in different contexts and can sometimes be modelled mathematically. Natural patterns include symmetries, trees, spirals, meanders, waves, foams, tessellations, cracks and stripes. Early Greek philosophers studied pattern, with Plato, Pythagoras and Empedocles attempting to explain order in nature. The modern understanding of visible patterns developed gradually over time. In the 19th century, the Belgian physicist Joseph Plateau examined soap films, leading him to formulate the concept of a minimal surface. The German biologist and artist Ernst Haeckel painted hundreds of marine organisms to emphasise their symmetry. Scottish biologist D'Arcy Thompson pioneered the study of growth patterns in both plants and animals, showing that simple equations could explain spiral growth. In the 20th century, the British mathematician Alan Turing predicted mechanisms of morphogenesis whi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cellular Differentiation
Cellular differentiation is the process in which a stem cell alters from one type to a differentiated one. Usually, the cell changes to a more specialized type. Differentiation happens multiple times during the development of a multicellular organism as it changes from a simple zygote to a complex system of tissues and cell types. Differentiation continues in adulthood as adult stem cells divide and create fully differentiated daughter cells during tissue repair and during normal cell turnover. Some differentiation occurs in response to antigen exposure. Differentiation dramatically changes a cell's size, shape, membrane potential, metabolic activity, and responsiveness to signals. These changes are largely due to highly controlled modifications in gene expression and are the study of epigenetics. With a few exceptions, cellular differentiation almost never involves a change in the DNA sequence itself. Although metabolic composition does get altered quite dramatical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Process
Biological processes are those processes that are vital for an organism to live, and that shape its capacities for interacting with its environment. Biological processes are made of many chemical reactions or other events that are involved in the persistence and transformation of life forms. Metabolism and homeostasis are examples. Biological processes within an organism can also work as bioindicators. Scientists are able to look at an individual's biological processes to monitor the effects of environmental changes. Regulation of biological processes occurs when any process is modulated in its frequency, rate or extent. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. * Homeostasis: regulation of the internal environment to maintain a constant state; for example, sweating to reduce temperature * Organization: being structurally composed of one or more cells ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
On Growth And Form
''On Growth and Form'' is a book by the Scottish mathematical biologist D'Arcy Wentworth Thompson (1860–1948). The book is long – 793 pages in the first edition of 1917, 1116 pages in the second edition of 1942. The book covers many topics including the effects of scale on the shape of animals and plants, large ones necessarily being relatively thick in shape; the effects of surface tension in shaping soap films and similar structures such as cells; the logarithmic spiral as seen in mollusc shells and ruminant horns; the arrangement of leaves and other plant parts (phyllotaxis); and Thompson's own method of transformations, showing the changes in shape of animal skulls and other structures on a Cartesian grid. The work is widely admired by biologists, anthropologists and architects among others, but less often read than cited. Peter Medawar explains this as being because it clearly pioneered the use of mathematics in biology, and helped to defeat mystical ideas of vita ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Growth
Cell growth refers to an increase in the total mass of a cell, including both cytoplasmic, nuclear and organelle volume. Cell growth occurs when the overall rate of cellular biosynthesis (production of biomolecules or anabolism) is greater than the overall rate of cellular degradation (the destruction of biomolecules via the proteasome, lysosome or autophagy, or catabolism). Cell growth is not to be confused with cell division or the cell cycle, which are distinct processes that can occur alongside cell growth during the process of cell proliferation, where a cell, known as the mother cell, grows and divides to produce two daughter cells. Importantly, cell growth and cell division can also occur independently of one another. During early embryonic development ( cleavage of the zygote to form a morula and blastoderm), cell divisions occur repeatedly without cell growth. Conversely, some cells can grow without cell division or without any progression of the cell cycle, su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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