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Meta-analysis
A meta-analysis is a statistical analysis that combines the results of multiple scientific studies. Meta-analyses can be performed when there are multiple scientific studies addressing the same question, with each individual study reporting measurements that are expected to have some degree of error. The aim then is to use approaches from statistics to derive a pooled estimate closest to the unknown common truth based on how this error is perceived. Meta-analytic results are considered the most trustworthy source of evidence by the evidence-based medicine literature.Herrera Ortiz AF., Cadavid Camacho E, Cubillos Rojas J, Cadavid Camacho T, Zoe Guevara S, Tatiana Rincón Cuenca N, Vásquez Perdomo A, Del Castillo Herazo V, & Giraldo Malo R. A Practical Guide to Perform a Systematic Literature Review and Meta-analysis. Principles and Practice of Clinical Research. 2022;7(4):47–57. https://doi.org/10.21801/ppcrj.2021.74.6 Not only can meta-analyses provide an estimate of the u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Study Heterogeneity
In statistics, (between-) study heterogeneity is a phenomenon that commonly occurs when attempting to undertake a meta-analysis. In a simplistic scenario, studies whose results are to be combined in the meta-analysis would all be undertaken in the same way and to the same experimental protocols. Differences between outcomes would only be due to measurement error (and studies would hence be ''homogeneous''). Study heterogeneity denotes the variability in outcomes that goes beyond what would be expected (or could be explained) due to measurement error alone. Introduction Meta-analysis is a method used to combine the results of different trials in order to obtain a quantitative synthesis. The size of individual clinical trials is often too small to detect treatment effects reliably. Meta-analysis increases the power of statistical analyses by pooling the results of all available trials. As one tries to use meta-analysis to estimate a combined effect from a group of similar studies, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Individual Participant Data
Individual participant data (also known as individual patient data, often abbreviated IPD) is raw data from individual participants, and is often used in the context of meta-analysis. The International Committee of Medical Journal Editors (ICMJE) has stated that sharing of deidentified individual participant data is an ethical obligation. IPD meta-analysis In an IPD meta-analysis, patient-level data from multiple studies or settings are combined to address a certain research question. IPD meta-analyses tend to be common for large-scale and international projects, and they are less limited than aggregate data (AD) meta-analyses in terms of the availability and quality of data they can use. Due to the high level of precision and consistency this approach allows for (which in turn makes it easier for researchers to minimize heterogeneity Homogeneity and heterogeneity are concepts often used in the sciences and statistics relating to the uniformity of a substance or organism. A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meta-regression
Meta-regression is defined to be a meta-analysis that uses regression analysis to combine, compare, and synthesize research findings from multiple studies while adjusting for the effects of available covariates on a response variable. A meta-regression analysis aims to reconcile conflicting studies or corroborate consistent ones; a meta-regression analysis is therefore characterized by the collated studies and their corresponding data sets—whether the response variable is study-level (or equivalently ''aggregate'') data or individual participant data (or individual patient data in medicine). A data set is ''aggregate'' when it consists of summary statistics such as the sample mean, effect size, or odds ratio. On the other hand, individual participant data are in a sense ''raw'' in that all observations are reported with no abridgment and therefore no information loss. Aggregate data are easily compiled through internet search engines and therefore not expensive. However, individ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Systematic Review
A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. A systematic review extracts and interprets data from published studies on the topic, then analyzes, describes, and summarizes interpretations into a refined conclusion. For example, a systematic review of randomized controlled trials is a way of summarizing and implementing evidence-based medicine. While a systematic review may be applied in the biomedical or health care context, it may also be used where an assessment of a precisely defined subject can advance understanding in a field of research. A systematic review may examine clinical tests, public health interventions, environmental interventions, social interventions, adverse effects, qualitative evidence syntheses, methodological reviews, policy reviews, and economic evaluations. An understanding of systematic reviews and how to implement them in pra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jessica Gurevitch
Jessica Gurevitch is plant ecologist known for meta-analysis in the fields of ecology and evolution. Education and career Gurevitch has a B.S. from Cornell University (1973) and earned her Ph.D. in ecology and evolutionary biology from the University of Arizona in 1982. She was a postdoctoral fellow for two years at the University of Chicago before moving to the State University of New York at Stony Brook in 1985. For two years starting in 1992, Guervitch worked at the National Science Foundation before returning to Stony Brook where she was promoted to professor in 2000. From 2015 to 2016, Gurevitch was president of the Society for Research Synthesis Methodology. Research Gurevitch's research interests are centered on biological invasions and meta-analysis in ecology. Her research on grasses perennial plants, and trees relied on a combination of experimental manipulations and observation data. Her interest in biological invasions includes investigations into the invasive flo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Publication Bias
In published academic research, publication bias occurs when the outcome of an experiment or research study biases the decision to publish or otherwise distribute it. Publishing only results that show a significant finding disturbs the balance of findings in favor of positive results. The study of publication bias is an important topic in metascience. Despite similar quality of execution and design, papers with statistically significant results are three times more likely to be published than those with null results. This unduly motivates researchers to manipulate their practices to ensure statistically significant results, such as by data dredging. Many factors contribute to publication bias. For instance, once a scientific finding is well established, it may become newsworthy to publish reliable papers that fail to reject the null hypothesis. Most commonly, investigators simply decline to submit results, leading to non-response bias. Investigators may also assume they made a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Extrasensory Perception
Extrasensory perception or ESP, also called sixth sense, is a claimed paranormal ability pertaining to reception of information not gained through the recognized physical senses, but sensed with the mind. The term was adopted by Duke University psychologist J. B. Rhine to denote psychic abilities such as intuition, telepathy, psychometry, clairvoyance, clairaudience, clairsentience, empathy and their trans-temporal operation as precognition or retrocognition. Second sight is a form of extrasensory perception, whereby a person perceives information, in the form of a vision, about future events before they happen (precognition), or about things or events at remote locations ( remote viewing). There is no evidence that second sight exists. Reports of second sight are known only from anecdotes. Second sight and ESP are classified as pseudosciences. History In the 1930s, at Duke University in North Carolina, J. B. Rhine and his wife Louisa E. Rhine conducted an investigati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Research Synthesis
Research synthesis is the process of combining the results of multiple primary research studies aimed at testing the same conceptual hypothesis. It may be applied to either quantitative or qualitative research. Its general goals are to make the findings from multiple different studies more generalizable and applicable. It aims to generate new knowledge by combining and comparing the results of multiple studies on a given topic. One approach is to use a systematic review method. Techniques Meta-analysis is the preferred technique of quantitative research synthesis in many fields, such as medical science. It is a statistical technique that combines measures of effect size from a number of studies to calculate an overall measure. This measure of effect has greater precision Precision, precise or precisely may refer to: Science, and technology, and mathematics Mathematics and computing (general) * Accuracy and precision, measurement deviation from true value and its scatter * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Effect Size
In statistics, an effect size is a value measuring the strength of the relationship between two variables in a population, or a sample-based estimate of that quantity. It can refer to the value of a statistic calculated from a sample of data, the value of a parameter for a hypothetical population, or to the equation that operationalizes how statistics or parameters lead to the effect size value. Examples of effect sizes include the correlation between two variables, the regression coefficient in a regression, the mean difference, or the risk of a particular event (such as a heart attack) happening. Effect sizes complement statistical hypothesis testing, and play an important role in power analyses, sample size planning, and in meta-analyses. The cluster of data-analysis methods concerning effect sizes is referred to as estimation statistics. Effect size is an essential component when evaluating the strength of a statistical claim, and it is the first item (magnitude) in the MA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Preferred Reporting Items For Systematic Reviews And Meta-Analyses
PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) is an evidence-based minimum set of items aimed at helping scientific authors to report a wide array of systematic reviews and meta-analyses, primarily used to assess the benefits and harms of a health care intervention. PRISMA focuses on ways in which authors can ensure a transparent and complete reporting of this type of research. The PRISMA standard superseded the earlier QUOROM standard. It offers the replicability of a systematic literature review. Researchers have to figure out research objectives that answer the research question, states the keywords, a set of exclusion and inclusion criteria. In the review stage, relevant articles were searched, irrelevant ones are removed. Articles are analyzed according to some pre-defined categories. The PRISMA statement The aim of the PRISMA statement is to help authors improve the reporting of systematic reviews and meta-analyses. PRISMA has mainly focused on sy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Larry V
Larry is a masculine given name in English, derived from Lawrence or Laurence. It can be a shortened form of those names. Larry may refer to the following: People Arts and entertainment *Larry D. Alexander, American artist/writer * Larry Boone, American country singer * Larry Collins, American musician, member of the rockabilly sibling duo The Collins Kids * Larry David (born 1947), Emmy-winning American actor, writer, comedian, producer and film director * Larry Emdur, Australian TV host *Larry Feign, American cartoonist working in Hong Kong * Larry Fine, of the Three Stooges *Larry Gates, American actor *Larry Gatlin, American country singer * Larry Gelbart (1928–2009), American screenwriter, playwright, director and author *Larry Graham, founder of American funk band Graham Central Station *Larry Hagman, American actor, best known for the TV series ''I Dream of Jeannie'' and ''Dallas'' * Larry Henley (1937–2014), American singer and songwriter, member of The Newbeats * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frank L
Frank or Franks may refer to: People * Frank (given name) * Frank (surname) * Franks (surname) * Franks, a medieval Germanic people * Frank, a term in the Muslim world for all western Europeans, particularly during the Crusades - see Farang Currency * Liechtenstein franc or frank, the currency of Liechtenstein since 1920 * Swiss franc or frank, the currency of Switzerland since 1850 * Westphalian frank, currency of the Kingdom of Westphalia between 1808 and 1813 * The currencies of the German-speaking cantons of Switzerland (1803–1814): ** Appenzell frank ** Argovia frank ** Basel frank ** Berne frank ** Fribourg frank ** Glarus frank ** Graubünden frank ** Luzern frank ** Schaffhausen frank ** Schwyz frank ** Solothurn frank ** St. Gallen frank ** Thurgau frank ** Unterwalden frank ** Uri frank ** Zürich frank Places * Frank, Alberta, Canada, an urban community, formerly a village * Franks, Illinois, United States, an unincorporated community * Franks, Missour ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
