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Jak
Jak may refer to: Places * Ják, a village in Hungary People * Jak Alnwick (born 1993), English football goalkeeper * Jak Jones (born 1993), Welsh professional snooker player * Raymond Jackson ("JAK") (1927–1997), UK cartoonist * Jak Airport (c. 1955–2004), English guitarist born Jack Stafford * Jak Knight (1993–2022), American actor, comedian and writer * Jak Crawford (born 2005) an American racing driver * José Antonio Kast (born 1966), Chilean politician Fictional characters * Jak (Jak and Daxter), in ''Jak and Daxter'' video games * Jak (comics), in the UK comic book ''The Dandy'' Other uses * JAK members bank, a Swedish interest-free bank * Janus kinase, a family of intracellular, nonreceptor tyrosine kinases including ** Janus kinase 1 (JAK1) ** Janus kinase 2 (JAK2) ** Janus kinase 3 (JAK3) See also * Jack (other) Jack may refer to: Places * Jack, Alabama, US, an unincorporated community * Jack, Missouri, US, an unincorporated community * Jack County ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jak (Jak And Daxter)
This is a list of characters in the ''Jak and Daxter'' series, a video game franchise originally developed by Naughty Dog for the PlayStation 2. Currently, six games in the series have been released, with Jak as the primary playable character in all except ''Daxter'' for the PlayStation Portable. Character development Initial character design began in the year 2000, when Naughty Dog commissioned various artists to "scribble characters" for their next PlayStation 2 title. After several revisions, from wolf-like characters to various human concepts, Naughty Dog animator John Kim drew a concept of a "tall, slender, and agile" character that "sported jaunty, spiky hair," with an "exaggeration, weight, and thickness" that Kim described as "BAM!"; an internal mantra that served to describe the characteristics of the new personalities in the title. Bob Rafei proceeded with this concept and designed various concept art poses that would eventually depict a 15-year-old boy with spiky green ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Janus Kinase 3
Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the ''JAK3'' gene. Janus kinases Janus kinase 3 is a tyrosine kinase that belongs to the janus family of kinases. Other members of the Janus family include JAK1, JAK2 and TYK2. Janus kinases (JAKs) are relatively large kinases of approximately 1150 amino acids with apparent molecular weights of 120-130 kDa. They are cytosolic tyrosine kinases that are specifically associated with cytokine receptors. Since cytokine receptor proteins lack enzymatic activity, they are dependent upon JAKs to initiate signaling upon binding of their ligands (e.g. cytokines). The cytokine receptors can be divided into five major subgroups based on their different domains and activation motifs. JAK3 is required for signaling of the type I receptors that use the common gamma chain (γc).Studies suggest Jak3 plays essential roles in immune and nonimmune cell physiology. Epithelial Jak3 is important for the regulation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jak Alnwick
Jak Alnwick (born 17 June 1993) is an English professional footballer who plays as a goalkeeper for club Cardiff City. He turned professional at Newcastle United in 2008, and went on to represent England at under-17 and under-18 levels. He spent time on loan at Gateshead in the 2011–12 season and played six Premier League games for Newcastle in the 2014–15 season. He joined Bradford City on loan in March 2015, and Port Vale on a free transfer that August. He was sold to Rangers for an undisclosed fee in January 2017, though spent the 2018–19 season loan at Scunthorpe United after failing to earn a first-team place. He joined Blackpool on loan for the 2019–20 season. He joined St Mirren on a free transfer in June 2020 and spent two years with the club, before returning to the English Football League with Cardiff City in May 2022. Club career Newcastle United Alnwick joined Newcastle United from local rivals Sunderland in 2008. He won the Wor Jackie Award for the cl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jak (comics)
Jak Hurley and Todd Nolan are two fictional comic strip characters from the UK comic ''The Dandy'' who rose to popularity as the comic's main strip after its re-launch in 2004. Originally known as simply ''Jak'', both characters received equal billing after the popularity of Todd from readership. Character history Early strips (1997–2004) Jak's first incarnation was drawn by Jimmy Hansen starting from issue 2924, dated 6 December 1997. The strip played mostly on his relationship with his father (though not to the same extent as Molly and Beryl the Peril from that time). The second incarnation in the early 2000s (decade) was drawn by David Sutherland, who drew Jak's dad with black hair and a beard, and introduced a cat called Spike. Both strips portrayed Jak as younger than his modern-day counterpart and Todd was absent. Dandy re-launches (2004–2010) Finally, Jak was reincarnated with the ''Dandy'' from issue 3282, dated 16 October 2004, coinciding with the relaunch of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Janus Kinase 2
Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CSF receptor family ( IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors (e.g. Epo-R, Tpo-R, GH-R, PRL-R). The distinguishing feature between janus kinase 2 and other JAK kinases is the lack of Src homology binding domains ( SH2/ SH3) and the presence of up to seven JAK homology domains (JH1-JH7). Nonetheless the terminal JH domains retain a high level of homology to tyrosine kinase domains. An interesting note is that only one of these carboxy-terminal JH domains retains full kinase function (JH1) while the other (JH2), previously thought to have no kinase functionality and accordingly termed a pseudokinase domain, has since been found to be catalytically active, albeit at only 10% that of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Janus Kinase 1
JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jak Jones
Jak Jones (born 29 July 1993) is a Welsh professional snooker player. Jones was born in Cwmbran, Wales. He became a professional in 2010 at the age of 16, by winning the 2010 European Under 19 Snooker Championship in Malta. Career Professional debut In his first year on the tour, Jones could only win one match in his attempts to qualify for the seven ranking events. He played in all 12 of the minor-ranking Players Tour Championship events throughout the year, with his best results being two last 32 defeats to be placed 85th on the Order of Merit. He ended his debut season ranked world number 94 meaning he was relegated from the tour as he did not finish inside the top 64. 2011/2012 season Jones could only enter PTC events since dropping of the tour and he played in 10 of the 12. At the second event he beat Anthony Hamilton 4–3, James Wattana 4–2 and Sam Craigie 4–1 to reach the last 16, where he was edged out 3–4 by Rory McLeod. Two other last 32 defeats saw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jak Knight
Jakim Maulana (November 6, 1993 – July 14, 2022), known professionally as Jak Knight, was an American actor, comedian and writer. He was best known for his roles as DeVon in the animated Netflix sitcom '' Big Mouth'' and Jak in the Peacock comedy series '' Bust Down''. Early life Knight was born as Jakim Maulana in Seattle, Washington, on November 6, 1993. Career In 2014, he made his first acting role as an iPhone camera man in the film ''LieGuys''. From 2017 until his death in 2022, he provided the voice of DeVon in the Netflix adult animated sitcom '' Big Mouth''. In 2020, he provided vocal passages as interludes on Limbo, an album made by hip-hop artist and friend of Knight, Aminé. In March 2022, four months before his death, he starred in the Peacock comedy series '' Bust Down'', alongside Langston Kerman, Chris Redd and Sam Jay. Personal life He resided in Los Angeles. Death On July 14, 2022, Knight was found dead on an embankment in Los Angeles, California, at ag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jak Crawford
Carlton Jackston "Jak" Crawford (born 2 May 2005) is an American racing driver who most recently competed in the 2022 FIA Formula 3 Championship with Prema Racing. He is a member of the Red Bull Junior Team and finished as runner-up in the 2020 ADAC Formula 4 Championship. Career Karting Born in Charlotte, North Carolina, Crawford started his karting career in 2011 after he moved to the Houston, Texas area. He competed in multiple championships, predominantly in North America, winning the Challenge of the Americas - Junior Rotax Series among others. In Crawford's first overseas karting race in 2014 at the Rok Cup International Championship, while only 9 years old, he finished second. Other international karting competition was mostly sporadic but generally successful. Lower formulae In 2018, Crawford made his car racing debut in the NACAM Formula 4 Championship, driving for Scuderia Martiga EG. He won six races, and with eight further podiums the American driver finished sec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Janus Kinase
Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They were initially named "just another kinase" 1 and 2 (since they were just two of many discoveries in a PCR-based screen of kinases), but were ultimately published as "Janus kinase". The name is taken from the two-faced Roman god of beginnings, endings and duality, Janus, because the JAKs possess two near-identical phosphate-transferring domains. One domain exhibits the kinase activity, while the other negatively regulates the kinase activity of the first. Family The four JAK family members are: * Janus kinase 1 (JAK1) * Janus kinase 2 (JAK2) * Janus kinase 3 (JAK3) * Tyrosine kinase 2 (TYK2) Transgenic mice that do not express JAK1 have defective responses to some cytokines, such as interferon-gamma. JAK1 and JAK2 are involved in type II interferon (interferon-gamma) signalling, whereas JAK1 and TYK2 are involved in type I int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jak Airport
Jak Airport (born Jack Stafford; c. 1955 – 13 August 2004) was the guitarist of 1970s punk band X-Ray Spex and new wave band Classix Nouveaux, before retiring from music and working for Vision Video and the BBC. Born and raised in Catford, London, Jak Airport is best known and remembered for being a member of punk rock band X-Ray Spex, contributing with songs like " Oh Bondage Up Yours!" and " The Day The World Turned Day-Glo". The beginning riff of the latter song was considered a classic by the band's singer Poly Styrene. He joined the band after leaving another punk group called Puncture. When X-Ray Spex disbanded in 1979, he and the group's bassist Paul Dean formed Airport and Dean. In 1979, he and fellow X-Ray Spex member, drummer BP Hurding formed, alongside singer Sal Solo, the new wave band Classix Nouveaux, but he had left the band by the end of the year. He retired from the music industry The music industry consists of the individuals and organizations that ea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ják
Ják is a village in Vas County, on the western boundary of Hungary. Church of Saint George The parish church of Ják is the most complete Romanesque Church in Hungary. It was originally built as the church of a Benedictine monastery. The village church at that time was a rotunda in front of the façade of the main doorway of Ják church. Both outside and inside the church is adorned with rich sculptures. The 3 naves and 3 apses are formed in a basilica structure. Columnar capitals are sculptured by plant and some animal ornamentation. The rotunda has been built with 4 apses and 2 floors. Photo gallery File:Jákitemplom-34.JPG File:Apátsági templom (8941. számú műemlék) 9.jpg File:Apátsági templom (8941. számú műemlék) 10.jpg File:Apátsági templom (8941. számú műemlék) 3.jpg, Saint George's Abbey, Ják Image:Jaki templomcivertanlegi3.jpg File:Jákitemplom-16.JPG File:San Mateo en la Iglesia de Ják.jpg, Medieval relief of Saint Matthew Matthew the A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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