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Inhibace
Cilazapril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure. It was patented in 1982 and approved for medical use in 1990. Chemistry Of the eight possible stereoisomers, only the all-(''S'')-form is medically viable. Brand names It is branded as Dynorm, Inhibace, Vascace and many other names in various countries. None of these are available in the United States as of May 2010. . ''Drugs.com''. Retrieved 28 May 2010. References ACE inhibitors Carboxylic acids Enantiopure drugs Hoffmann-La Roche brands Ethyl esters Lactams Prodrugs Nitrogen heterocycles Heterocyclic compounds with 2 rings Carboxylate esters {{cardiovascular-drug-stub ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ACE Inhibitors
Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of high blood pressure and heart failure. They work by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart. ACE inhibitors inhibit the activity of angiotensin-converting enzyme, an important component of the renin–angiotensin system which converts angiotensin I to angiotensin II, and hydrolyses bradykinin. Therefore, ACE inhibitors decrease the formation of angiotensin II, a vasoconstrictor, and increase the level of bradykinin, a peptide vasodilator. This combination is synergistic in lowering blood pressure. As a result of inhibiting the ACE enzyme in the bradykinin system, the ACE inhibitor drugs allow for increased levels of bradykinin which would normally be degraded. Bradykinin produces prostaglandin. This mechanism can explain the two most common side e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |