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Gerty Cori
Gerty Theresa Cori (; August 15, 1896 – October 26, 1957) was an Austro-Hungarian and American biochemist who in 1947 was the third woman to win a Nobel Prize in science, and the first woman to be awarded the Nobel Prize in Physiology or Medicine, for her significant role in the "discovery of the course of the catalytic conversion of glycogen". Cori was born in Prague (then in the Austro-Hungarian Empire, now the Czech Republic). Gerty was not a nickname, but rather she was named after an Austrian warship. Growing up at a time when women were marginalized in science and allowed few educational opportunities, she gained admittance to medical school, where she met her future husband Carl Ferdinand Cori in an anatomy class; upon their graduation in 1920, they married. Because of deteriorating conditions in Europe, the couple emigrated to the United States in 1922. Gerty Cori continued her early interest in medical research, collaborating in the laboratory with Carl. She publish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prague
Prague ( ; cs, Praha ; german: Prag, ; la, Praga) is the capital and List of cities in the Czech Republic, largest city in the Czech Republic, and the historical capital of Bohemia. On the Vltava river, Prague is home to about 1.3 million people. The city has a temperate climate, temperate oceanic climate, with relatively warm summers and chilly winters. Prague is a political, cultural, and economic hub of central Europe, with a rich history and Romanesque architecture, Romanesque, Czech Gothic architecture, Gothic, Czech Renaissance architecture, Renaissance and Czech Baroque architecture, Baroque architectures. It was the capital of the Kingdom of Bohemia and residence of several Holy Roman Emperors, most notably Charles IV, Holy Roman Emperor, Charles IV (r. 1346–1378). It was an important city to the Habsburg monarchy and Austro-Hungarian Empire. The city played major roles in the Bohemian Reformation, Bohemian and the Protestant Reformations, the Thirty Year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bernardo Houssay
Bernardo Alberto Houssay (April 10, 1887 – September 21, 1971) was an Argentine physiologist. Houssay was a co-recipient of the 1947 Nobel Prize for Physiology or Medicine for discovering the role played by pituitary hormones in regulating the amount of glucose in animals, sharing the prize with Carl Ferdinand Cori and Gerty Cori. He is the first Argentine Nobel laureate in the sciences. Biography Early life Bernardo Alberto Houssay was born April 10, 1887, in Buenos Aires. His parents Albert and Clara Houssay were immigrants from France. A precocious youngster, he was admitted to the Pharmacy School at the University of Buenos Aires at 14 years of age and subsequently to the Faculty of Medicine of the same university at 17 years old and was there from 1904 to 1910. While a third-year medical student, Houssay took up a post as a research and teaching assistant in the Chair of Physiology. Career After graduating, he quickly developed and presented his M.D. thesis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carl Cori
Carl Ferdinand Cori, ForMemRS (December 5, 1896 – October 20, 1984) was an Austrian-American biochemist and pharmacologist born in Prague (then in Austria-Hungary, now Czech Republic) who, together with his wife Gerty Cori and Argentine physiologist Bernardo Houssay, received a Nobel Prize in 1947 for their discovery of how the glucose derivative glycogen (animal starch) is broken down and resynthesized in the body for use as a store and source of energy. In 2004, both Coris were designated a National Historic Chemical Landmark in recognition of their work that elucidated carbohydrate metabolism. Education and early life Carl was the son of Carl Isidor Cori (1865, Brüx _cs.html" ;"title="/nowiki> cs"> Most Bohemia, Austrian Empire1954, Vienna), a zoologist, and Maria Cori (née Lippich; 1870, Graz1922, Prague), a daughter of the Italian-Bohemian/Austrian physician (1838, Padua1913, Prague). The Cori family came from the Papal State (later the Roman Republic, today's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lyceum
The lyceum is a category of educational institution defined within the education system of many countries, mainly in Europe. The definition varies among countries; usually it is a type of secondary school. Generally in that type of school the things that are taught are basic science and also in some part of that type of schools, some introduction to specific kind of jobs also may be done. History ''Lyceum'' is a Latin rendering of the Ancient Greek (), the name of a '' gymnasium'' in Classical Athens dedicated to Apollo Lyceus. This original lyceum is remembered as the location of the peripatetic school of Aristotle. Some countries derive the name for their modern schools from the Latin but use the Greek name for the ancient school: for example, Dutch has (ancient) and (modern), both rendered ''lyceum'' in English (note that in classical Latin the ''C'' in was always pronounced as a ''K'', not a soft ''C'', as in modern English). The name ''lycée'' was retrieved and utili ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Franz Kafka
Franz Kafka (3 July 1883 – 3 June 1924) was a German-speaking Bohemian novelist and short-story writer, widely regarded as one of the major figures of 20th-century literature. His work fuses elements of realism and the fantastic. It typically features isolated protagonists facing bizarre or surrealistic predicaments and incomprehensible socio-bureaucratic powers. It has been interpreted as exploring themes of alienation, existential anxiety, guilt, and absurdity. His best known works include the short story "The Metamorphosis" and novels ''The Trial'' and '' The Castle''. The term ''Kafkaesque'' has entered English to describe absurd situations, like those depicted in his writing. Kafka was born into a middle-class German-speaking Czech Jewish family in Prague, the capital of the Kingdom of Bohemia, then part of the Austro-Hungarian Empire, today the capital of the Czech Republic. He trained as a lawyer and after completing his legal education was employed full-ti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sugar Refinery
A sugar refinery is a refinery which processes raw sugar from cane or beets into white refined sugar. Many cane sugar mills produce raw sugar, which is sugar that still contains molasses, giving it more colour (and impurities) than the white sugar which is normally consumed in households and used as an ingredient in soft drinks and foods. While cane sugar does not need refining to be palatable, sugar from sugar beet is almost always refined to remove the strong, usually unwanted, taste of beets from it. The refined sugar produced is more than 99 percent pure sucrose. Many sugar mills only operate during the harvest season, whereas refineries may work the year round. Sugar beet refineries tend to have shorter periods when they process beet than cane refineries, but may store intermediate product and process it in the off-season. Raw sugar is either processed and sold locally, or is exported and refined elsewhere. History Sugar refineries date back to Arab Egypt in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jewish
Jews ( he, יְהוּדִים, , ) or Jewish people are an ethnoreligious group and nation originating from the Israelites Israelite origins and kingdom: "The first act in the long drama of Jewish history is the age of the Israelites""The people of the Kingdom of Israel and the ethnic and religious group known as the Jewish people that descended from them have been subjected to a number of forced migrations in their history" and Hebrews of historical Israel and Judah. Jewish ethnicity, nationhood, and religion are strongly interrelated, "Historically, the religious and ethnic dimensions of Jewish identity have been closely interwoven. In fact, so closely bound are they, that the traditional Jewish lexicon hardly distinguishes between the two concepts. Jewish religious practice, by definition, was observed exclusively by the Jewish people, and notions of Jewish peoplehood, nation, and community were suffused with faith in the Jewish God, the practice of Jewish (religious) la ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myelosclerosis
Primary myelofibrosis (PMF) is a rare bone marrow blood cancer. It is classified by the World Health Organization (WHO) as a type of myeloproliferative neoplasm, a group of cancers in which there is growth of abnormal cells in the bone marrow. This is most often associated with a somatic mutation in the JAK2, CALR, or MPL gene markers. In PMF, the healthy marrow is replaced by scar tissue (fibrosis), resulting in a lack of production of normal blood cells. Symptoms include anemia, increased infection and an enlarged spleen (splenomegaly). In 2016, prefibrotic primary myelofibrosis was formally classified as a distinct condition that progresses to overt PMF in many patients, the primary diagnostic difference being the grade of fibrosis. Signs and symptoms The primary feature of primary myelofibrosis is bone marrow fibrosis, but it is often accompanied by: * Abdominal fullness related to an enlarged spleen (splenomegaly). * Bone pain * Bruising and easy bleeding due to inadequat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Chemical Society
The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all degree levels and in all fields of chemistry, chemical engineering, and related fields. It is one of the world's largest scientific societies by membership. The ACS is a 501(c)(3) non-profit organization and holds a congressional charter under Title 36 of the United States Code. Its headquarters are located in Washington, D.C., and it has a large concentration of staff in Columbus, Ohio. The ACS is a leading source of scientific information through its peer-reviewed scientific journals, national conferences, and the Chemical Abstracts Service. Its publications division produces over 60 scholarly journals including the prestigious ''Journal of the American Chemical Society'', as well as the weekly trade magazine '' Chemical & Enginee ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbohydrate Metabolism
Carbohydrate metabolism is the whole of the biochemistry, biochemical processes responsible for the metabolic anabolism, formation, catabolism, breakdown, and interconversion of carbohydrates in life, living organisms. Carbohydrates are central to many essential metabolic pathways. Plants synthesize carbohydrates from carbon dioxide and water through photosynthesis, allowing them to store energy absorbed from sunlight internally. When animals and fungi consume plants, they use cellular respiration to break down these stored carbohydrates to make energy available to cells. Both animals and plants temporarily store the released energy in the form of high-energy molecules, such as Adenosine triphosphate, ATP, for use in various cellular processes. Humans can consume a variety of carbohydrates, digestion breaks down complex carbohydrates into simple monomers (monosaccharides): glucose, fructose, mannose and galactose. After resorption (digestion), resorption in the human digestive sys ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Historic Chemical Landmarks
The National Historic Chemical Landmarks program was launched by the American Chemical Society in 1992 to recognize significant achievements in the history of chemistry and related professions. The program celebrates the centrality of chemistry. The designation of such generative achievements in the history of chemistry demonstrates how chemists have benefited society by fulfilling the ACS vision: Improving people's lives through the transforming power of chemistry. The program occasionally designates International Historic Chemical Landmarks to commemorate "chemists and chemistry from around the world that have had a major impact in the United States". List of landmarks 1993 *Bakelite, the world's first completely synthetic plastic, developed by Leo Baekeland around 1907 1994 * Chandler Chemistry Laboratory at Lehigh University, constructed in 1884 *Joseph Priestley House, U.S. home of Joseph Priestley, discoverer of oxygen, from 1798 to 1804 1995 *Research on the atomic w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cori Ester
Glucose 1-phosphate (also called cori ester) is a glucose molecule with a phosphate group on the 1'-carbon. It can exist in either the α- or β-anomeric form. Reactions of α-glucose 1-phosphate Catabolic In glycogenolysis, it is the direct product of the reaction in which glycogen phosphorylase cleaves off a molecule of glucose from a greater glycogen structure. A deficiency of muscle glycogen phosphorylase is known as glycogen storage disease type V (McArdle Disease). To be utilized in cellular catabolism it must first be converted to glucose 6-phosphate by the enzyme phosphoglucomutase in a free equilibrium. One reason that cells form glucose 1-phosphate instead of glucose during glycogen breakdown is that the very polar phosphorylated glucose cannot leave the cell membrane and so is marked for intracellular catabolism. Phosphoglucomutase-1 deficiency is known as glycogen storage disease type 14 (GSD XIV). Anabolic In glycogenesis, free glucose 1-phosphate can also react w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
