|
Ernest Fourneau
Ernest Fourneau (4 October 1872 – 5 August 1949) was a French pharmacist graduated in Pharmacy 1898 for the Paris university specialist in medicinal chemical and pharmacology who played a major role in the discovery of synthetic local anesthetics, as well as in the synthesis of suramin. He authored more than two hundred scholarly works, and has been described as having "helped to establish the fundamental laws of chemotherapy that have saved so many human lives". Fourneau was a pupil of Friedel and Moureu, and studied in the German laboratories of Ludwig Gattermann in Heidelberg, Hermann Emil Fischer in Berlin and Richard Willstätter in Munich. He headed the research laboratory of Poulenc Frères in Ivry-sur-Seine from 1903 to 1911. One of the products was a synthetic local anesthetic that was named Stovaine (amylocaine). This was a pun on the English translation of "fourneau" as "stove". (The same pun was used in the brand name of the drug acetarsol, Stovarsol.) Other im ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jean-Claude Fourneau
Jean-Claude Fourneau (28 March 1907 – 9 October 1981) was a French painter close to the surrealist movement. His mother was a descendant of Victor de Lanneau, restorer of the Collège Sainte-Barbe in Paris, of Juliette Adam, founder of a French paper, ''La Nouvelle Revue'', muse of Léon Gambetta and the spiritual mother of Pierre Loti; and she was the daughter of Paul Segond, pioneer in the field of surgical gynaecology. His father, Ernest Fourneau, was the founder of French medicinal chemistry. Biography Draughtsman and painter imbued with classicism and surrealism, Jean-Claude Fourneau is first noticed at his show at the Jeanne Castel Gallery by André Salmon in 1932. He continued exhibiting there until 1948. Claude Roger-Marx sees his use of drawing as a medium and appreciates their detail: "The detail in Jean-Claude Fourneau's drawings gives us a sense of the infinite (...) Fascinating in the power and sensitivity that every stroke of his brush conveys." For the lit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hermann Emil Fischer
Hermann Emil Louis Fischer (; 9 October 1852 – 15 July 1919) was a German chemist and 1902 recipient of the Nobel Prize in Chemistry. He discovered the Fischer esterification. He also developed the Fischer projection, a symbolic way of drawing asymmetric carbon atoms. He also hypothesized lock and key mechanism of enzyme action. He never used his first given name, and was known throughout his life simply as Emil Fischer. Early years and career Fischer was born in Euskirchen, near Cologne, the son of Laurenz Fischer, a businessman, and his wife Julie Poensgen. After graduating he wished to study natural sciences, but his father compelled him to work in the family business until determining that his son was unsuitable. Fischer then attended the University of Bonn in 1871, but switched to the University of Strasbourg in 1872. He earned his doctorate in 1874 under Adolf von Baeyer with his study of phthaleins, and was appointed to a position at the university. After eight y ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
French Pharmacologists
French (french: français(e), link=no) may refer to: * Something of, from, or related to France ** French language, which originated in France, and its various dialects and accents ** French people, a nation and ethnic group identified with France ** French cuisine French cuisine () is the cooking traditions and practices from France. It has been influenced over the centuries by the many surrounding cultures of Spain, Italy, Switzerland, Germany and Belgium, in addition to the food traditions of the re ..., cooking traditions and practices Fortnite French places Arts and media * The French (band), a British rock band * "French" (episode), a live-action episode of ''The Super Mario Bros. Super Show!'' * Française (film), ''Française'' (film), 2008 * French Stewart (born 1964), American actor Other uses * French (surname), a surname (including a list of people with the name) * French (tunic), a particular type of military jacket or tunic used in the Russian Empire and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
French Biochemists
French (french: français(e), link=no) may refer to: * Something of, from, or related to France ** French language, which originated in France, and its various dialects and accents ** French people, a nation and ethnic group identified with France ** French cuisine, cooking traditions and practices Fortnite French places Arts and media * The French (band), a British rock band * "French" (episode), a live-action episode of ''The Super Mario Bros. Super Show!'' * ''Française'' (film), 2008 * French Stewart (born 1964), American actor Other uses * French (surname), a surname (including a list of people with the name) * French (tunic), a particular type of military jacket or tunic used in the Russian Empire and Soviet Union * French's, an American brand of mustard condiment * French catheter scale, a unit of measurement of diameter * French Defence, a chess opening * French kiss, a type of kiss involving the tongue See also * France (other) * Franch, a surname * Fren ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Académie Nationale De Médecine
Situated at 16 Rue Bonaparte in the 6th arrondissement of Paris, the Académie nationale de médecine (National Academy of Medicine) was created in 1820 by King Louis XVIII at the urging of baron Antoine Portal. At its inception, the institution was known as the Académie royale de médecine (or ''Royal Academy of Medicine''). This academy was endowed with the legal status of two institutions which preceded it—the Académie royale de chirurgie (or ''Royal Academy of Surgery''), which was created in 1731 and of the Société royale de médecine (or ''Royal Society of Medicine''), which was created in 1776. Background Academy members initially convened at the ''Paris Faculty of Medicine (or Faculté de Médecine de Paris)''. Four years later, the academy acquired its own headquarters, in the form of a mansion in the rue de Poitiers, where it was located until 1850. The office was then relocated to a vaulted hall of the Hospital of Charity on rue Saint Pierre. Their current ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Germaine Benoit
Germaine Benoit (9 October 1901 – April 1983)#uielem_move=237.60000610351562%2C75&uielem_islocked=0&uielem_zoom=67&uielem_brightness=0&uielem_contrast=0&uielem_isinverted=0&uielem_rotate=F" target="_blank" class="mw-redirect" title="Archives en ligne de Paris ">Archives en ligne de Paris année 1901, acte de naissance , cote V4E 9957, vue 25/31 (avec mention marginale de décès) was a French chemical engineer, |
Medicinal Chemistry
Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Medicinal chemistry is a highly interdisciplinary science combining organic chemistry with biochemistry, computational chemistry, pharmacology, molecular biology, statistics, and physical chemistry. Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules (e.g., atorvastatin, fluticasone, clopidogrel) and "biologics" (infliximab, erythropoietin, insulin glargine), the latter of which are most often medicinal preparations of proteins (natural and recombinant anti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antipyretic
An antipyretic (, from ''anti-'' 'against' and ' 'feverish') is a substance that reduces fever. Antipyretics cause the hypothalamus to override a prostaglandin-induced increase in temperature. The body then works to lower the temperature, which results in a reduction in fever. Most antipyretic medications have other purposes. The most common antipyretics in the US are usually ibuprofen and aspirin, which are nonsteroidal anti-inflammatory drugs (NSAIDs) used primarily as anti-inflammatories and analgesics (pain relievers), but which also have antipyretic properties; and paracetamol (acetaminophen), an analgesic without anti-inflammatory properties. There is some debate over the appropriate use of such medications, since fever is part of the body's immune response to infection. A study published by the Royal Society claims that fever suppression causes at least 1% more influenza deaths in the United States, or 700 extra deaths per year. Non-pharmacological treatment Bathing or s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetarsol
Acetarsol (or acetarsone) is an anti- infective drug. It was first discovered in 1921 at Pasteur Institute by Ernest Fourneau, and sold under the brand name Stovarsol. It has been given in the form of suppositories. Acetarsol can be used to make arsthinol. It has been cancelled and withdrawn from the market since August 12th, 1997. Medical uses Acetarsol has been used for the treatment of diseases such as syphilis, amoebiasis, yaws, trypanosomiasisiasis and malaria. Acetarsol was used for the treatment of ''Trichomonas Vaginalis'' and ''Candida Albicans.'' In the oral form, acetarsol can be used for the treatment of intestinal amoebiasis. As a suppository, acetarsol was researched to be used for the treatment of proctitis. Mechanism of Action Although the mechanism of action is not fully known, acetarsol may bind to protein-containing sulfhydryl groups located in the parasite, which then creates lethal As-S bonds, which then kills the parasite. Chemistry and pharma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amylocaine
Amylocaine was the first synthetic local anesthetic. It was synthesized and patented under the name Stovaine by Ernest Fourneau at the Pasteur Institute in 1903. It was used mostly in spinal anesthesia.Debue-Barazer, Christine (2007)"Les Implications scientifiques et industrielles du succès de la Stovaïne : Ernest Fourneau (1872-1949) et la chimie des médicaments en France". ''Gesnerus'' 64 (1-2): 24-53. Synthesis Grignard reaction of chloroacetone Chloroacetone is a chemical compound with the chemical formula, formula . At Standard conditions for temperature and pressure, STP it is a colourless liquid with a pungent odour. On exposure to light, it turns to a dark yellow-amber colour. It wa ... (1) with one mole of magnesium ethyl bromide gives 1-chloro-2-methyl-butan-2-ol 4283-48-0(2). Heating with dimethylamine gives 1-(dimethylamino)-2-methylbutan-2-ol 4347-10-7(3). These two steps can also be treated as interchangeable. Esterification with benzoyl chloride completed the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ivry-sur-Seine
Ivry-sur-Seine () is a commune in the Val-de-Marne department in the southeastern suburbs of Paris, France. It is located from the centre of Paris. Paris's main Asian district, the Quartier Asiatique in the 13th arrondissement, borders the commune and now extends into the northern parts of Ivry. Asian commercial activity, especially Chinese and Vietnamese, has greatly increased in Ivry-sur-Seine during the past two decades. The commune contains one of the highest concentrations of Vietnamese in France, who began settling in the city in the late 1970s after the Vietnam War. Politically, Ivry-sur-Seine has historically demonstrated strong electoral support for the French Communist Party (PCF). Between 1925 and today (except for the period of German occupation in World War II), the office of mayor was held by just four individuals: Georges Marrane, Jacques Laloë, Pierre Gosnat and Philippe Bouyssou, all members of the Communist Party. Ivry-sur-Seine is twinned with Bish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poulenc Frères
Poulenc Frères (Poulenc Brothers) was a French chemical, pharmaceutical and photographic supplies company that had its origins in a Paris pharmacy founded in 1827. From 1852 it began to manufacture (or package) photographic chemicals. It took the name Poulenc Frères in 1881, and by 1900 had a range of high-quality products. That year it went public as the Établissements Poulenc Frères. It began production of synthetic medicines, and continued to grow during World War I (1914–18). In 1928 it merged with the Société des usines chimiques du Rhône to form Rhône-Poulenc. Origins The company can trace its roots to the Pharmacie-Droguerie Hédouin, a pharmacy founded in 1827 in the rue Saint-Merri, Paris. The baker Pierre Wittman (1798–1880) bought the store in 1845. His daughter, Pauline Wittmann (1828–1910), married Étienne Poulenc (1823–78) in February 1851. They had three sons: Gaston (1852–1948), Emile (1855–1917) and Camille (1864–1942). Etienne Poulenc was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
.jpg "Click for more on -> Poulenc Frères")