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Coca
Coca is any of the four cultivated plants in the family Erythroxylaceae, native to western South America. Coca is known worldwide for its psychoactive alkaloid, cocaine. The plant is grown as a cash crop in the Argentine Northwest, Bolivia, Alto Rio Negro Territory in Brazil, Colombia, Venezuela, Ecuador, and Peru, even in areas where its cultivation is unlawful. There are some reports that the plant is being cultivated in the south of Mexico, by using seeds imported from South America, as an alternative to smuggling its recreational product cocaine. It also plays a role in many traditional Amazonian and Andean cultures as well as the Sierra Nevada de Santa Marta in northern Colombia. The cocaine alkaloid content of dry ''Erythroxylum coca'' var. ''coca'' leaves was measured ranging from 0.23% to 0.96%. Coca-Cola used coca leaf extract in its products from 1885 until about 1903, when it began using decocainized leaf extract. Extraction of cocaine from coca requires several s ...
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Cocaine
Cocaine (from , from , ultimately from Quechua: ''kúka'') is a central nervous system (CNS) stimulant mainly used recreationally for its euphoric effects. It is primarily obtained from the leaves of two Coca species native to South America, ''Erythroxylum coca'' and ''Erythroxylum novogranatense''. After extraction from coca leaves and further processing into cocaine hydrochloride (powdered cocaine), the drug is often snorted, applied topically to the mouth, or dissolved and injected into a vein. It can also then be turned into free base form ( crack cocaine), in which it can be heated until sublimated and then the vapours can be inhaled. Cocaine stimulates the reward pathway in the brain. Mental effects may include an intense feeling of happiness, sexual arousal, loss of contact with reality, or agitation. Physical effects may include a fast heart rate, sweating, and dilated pupils. High doses can result in high blood pressure or high body temperature. Effects ...
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Cocaine
Cocaine (from , from , ultimately from Quechua: ''kúka'') is a central nervous system (CNS) stimulant mainly used recreationally for its euphoric effects. It is primarily obtained from the leaves of two Coca species native to South America, ''Erythroxylum coca'' and ''Erythroxylum novogranatense''. After extraction from coca leaves and further processing into cocaine hydrochloride (powdered cocaine), the drug is often snorted, applied topically to the mouth, or dissolved and injected into a vein. It can also then be turned into free base form ( crack cocaine), in which it can be heated until sublimated and then the vapours can be inhaled. Cocaine stimulates the reward pathway in the brain. Mental effects may include an intense feeling of happiness, sexual arousal, loss of contact with reality, or agitation. Physical effects may include a fast heart rate, sweating, and dilated pupils. High doses can result in high blood pressure or high body temperature. Effects ...
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Coca-Cola
Coca-Cola, or Coke, is a carbonated soft drink manufactured by the Coca-Cola Company. Originally marketed as a temperance drink and intended as a patent medicine, it was invented in the late 19th century by John Stith Pemberton in Atlanta, Georgia. In 1888, Pemberton sold Coca-Cola's ownership rights to Asa Griggs Candler, a businessman, whose marketing tactics led Coca-Cola to its dominance of the global soft-drink market throughout the 20th and 21st century. The drink's name refers to two of its original ingredients: coca leaves and kola nuts (a source of caffeine). The current formula of Coca-Cola remains a closely guarded trade secret; however, a variety of reported recipes and experimental recreations have been published. The secrecy around the formula has been used by Coca-Cola in its marketing as only a handful of anonymous employees know the formula. The drink has inspired imitators and created a whole classification of soft drink: colas. The Coca-Cola Company p ...
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Erythroxylum Coca
''Erythroxylum coca'' is one of two species of cultivated coca. Description The coca plant resembles a blackthorn bush, and grows to a height of . The branches are straight, and the leaves, which have a green tint, are thin, opaque, oval, and taper at the extremities. A marked characteristic of the leaf is an areolated portion bounded by two longitudinal curved lines, one line on each side of the midrib, and more conspicuous on the underside of the leaf. The flowers are small, and disposed in little clusters on short stalks; the corolla is composed of five yellowish-white petals, the anthers are heart-shaped, and the pistil consists of three carpels united to form a three-chambered ovary. The flowers mature into red berries. Unlike ''Erythroxylum novogranatense'', ''Erythroxylum coca'' requires very acidic soil conditions. Soil acidity and water acidity need to be below pH 5.5, with the optimal value being pH 3.5, similar to that of ''Rhododendron'' potting soils. At pH 6.5 and ...
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Illegal Drug Trade
The illegal drug trade or drug trafficking is a global black market dedicated to the cultivation, manufacture, distribution and sale of prohibited drugs. Most jurisdictions prohibit trade, except under license, of many types of drugs through the use of drug prohibition laws. The think tank Global Financial Integrity's ''Transnational Crime and the Developing World'' report estimates the size of the global illicit drug market between US$426 and US$652billion in 2014 alone. With a world GDP of US$78 trillion in the same year, the illegal drug trade may be estimated as nearly 1% of total global trade. Consumption of illegal drugs is widespread globally and it remains very difficult for local authorities to thwart its popularity. History The government of the Qing Dynasty issued edicts against opium smoking in 1730, 1796 and 1800. The West prohibited addictive drugs throughout the late 19th and early 20th centuries. Beginning in the 18th century, British merchants fr ...
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Erythroxylum Novogranatense
''Erythroxylum novogranatense'' is a neotropical species of '' Erythroxylum'' ( Erythroxylaceae). Cocaine is produced from the leaves. Name "Novogranatense" is derived from Latin: ''novo'' (new) and ''granatense'' (Granada). It was named by William Turner Thiselton-Dyer, the third director of Royal Botanic Gardens, Kew, because its country of origin was the Spanish colonial Viceroyalty of New Granada—present day Colombia. Subspecies ''Erythroxylum novogranatense'' contains 2 subspecies: *''Erythroxylum novogranatense'' var. ''novogranatense'' (D.Morris) Hieron *''Erythroxylum novogranatense'' var. ''truxillense'' (Rusby) Plowman These two subspecies are phenotypically similar, but morphologically distinguishable. Taxonomy Among the genus ''Erythroxylum'', cocaine-rich leaves are obtained from 4 taxa: *'' Erythroxylum coca'' var. ''coca'' *''Erythroxylum coca'' var. '' ipadu'' *''Erythroxylum novogranatense'' var. ''novogranatense'' *''Erythroxylum novogranatense'' var. ''t ...
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Benzoylecgonine
Benzoylecgonine is the main metabolite of cocaine, formed by the liver and excreted in the urine. It is the compound tested for in most cocaine urine drug screens. Pharmacokinetics Chemically, benzoylecgonine is the benzoate ester of ecgonine. It is a primary metabolite of cocaine, and is pharmacologically inactive. Urinalysis Benzoylecgonine is the compound tested for in most substantive cocaine drug urinalyses. It is the corresponding carboxylic acid of cocaine, its methyl ester. It is formed in the liver by the metabolism of cocaine by hydrolysis, catalysed by carboxylesterases, and subsequently excreted in the urine. Presence in drinking water Benzoylecgonine is sometimes found in drinking water supplies. In 2005, scientists found surprisingly large quantities of benzoylecgonine in Italy's Po River and used its concentration to estimate the number of cocaine users in the region. In 2006, a similar study was performed in the Swiss ski town of Saint-Moritz using wastewater t ...
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Bolivia
, image_flag = Bandera de Bolivia (Estado).svg , flag_alt = Horizontal tricolor (red, yellow, and green from top to bottom) with the coat of arms of Bolivia in the center , flag_alt2 = 7 × 7 square patchwork with the (top left to bottom right) diagonals forming colored stripes (green, blue, purple, red, orange, yellow, white, green, blue, purple, red, orange, yellow, from top right to bottom left) , other_symbol = , other_symbol_type = Dual flag: , image_coat = Escudo de Bolivia.svg , national_anthem = " National Anthem of Bolivia" , image_map = BOL orthographic.svg , map_width = 220px , alt_map = , image_map2 = , alt_map2 = , map_caption = , capital = La Paz Sucre , largest_city = , official_languages = Spanish , languages_type = Co-official languages , languages ...
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Coca Alkaloid
Coca alkaloids are the alkaloids found in the coca plant, ''Erythroxylum coca''.Variation of Alkaloid Content in Erythroxylum coca Leaves from Leaf Bud to Leaf Drop. Emanuel L. Johnson and Stephen D. Emche, Ann. Bot., 1994, volume 73, issue 6, pages 645-650, They are predominantly of either the pyrrolidine or the tropane types. __NOTOC__ Tropane-type alkaloids * Benzoylecgonine * Cocaine * Ecgonidine * Ecgonine * Hydroxytropacocaine * Methylecgonine cinnamate * Tropacocaine * Truxilline Pyrrolidine-type alkaloids * Cuscohygrine * Dihydrocuscohygrine * Hygrine * Nicotine See also * Cocaine metabolites (Human) * Coca wine, an alcoholic beverage combining wine with extracted coca alkaloids * Methylecgonidine * Troparil Troparil (also known as (–)-2β-Carbomethoxy-3β-phenyltropane, WIN 35,065-2, or β-CPT) is a stimulant drug used in scientific research. Troparil is a phenyltropane-based dopamine reuptake inhibitor (DRI) that is derived from methylecgonidine ... ...
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Erythroxylaceae
Erythroxylaceae (the coca family) is a family of flowering trees and shrubs consisting of 4 genera and 271 species. The four genera are ''Aneulophus'' Benth., ''Erythroxylum'' P.Browne, ''Nectaropetalum'' Engl., and ''Pinacopodium'' Exell & Mendonça. The best-known species are the coca plants, including the species ''Erythroxylum coca'', the source of the substance coca Coca is any of the four cultivated plants in the family Erythroxylaceae, native to western South America. Coca is known worldwide for its psychoactive alkaloid, cocaine. The plant is grown as a cash crop in the Argentine Northwest, Bolivia, .... References Malpighiales families {{Malpighiales-stub ...
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Psychoactive Plant
Psychoactive plants are plants, or preparations thereof, that upon ingestion induce psychotropic effects. As stated in a reference work: Psychoactivity may include sedative, stimulant, euphoric, deliriant, and hallucinogenic effects. Several hundred psychoactive plants are known. Some popular examples of psychoactive plants include ''Coffea arabica'' (coffee), ''Camellia sinensis'' ( tea), ''Nicotiana tabacum'' (tobacco), and ''Cannabis'' (including hashish). Psychoactive plants have been used ritually (''e.g.'', peyote as an entheogen), medicinally (''e.g.'', opium as an analgesic), and therapeutically (''e.g.'', cannabis as a drug) for thousands of years. Hence, the sociocultural and economic significance of psychoactive plants is enormous. Examples of psychoactive plants In the table below, a few examples of significant psychoactive plants and their effects are shown. For further examples, see List of psychoactive plants. Botanical taxonomy Botanical taxonomy ...
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Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids
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Alkaloids are produced by a large variety of organisms including , ,