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Clortermine
Clortermine (Voranil) was developed by Ciba in the 1960s and is an anorectic drug of the amphetamine class. It is the 2-chloro analogue of the better known appetite suppressant phentermine, and is the 2-chloro positional isomer of chlorphentermine. Clortermine produces very low rates of self-administration in animals similarly to chlorphentermine, and as a result it likely does not act on dopamine. Instead, it may act as a serotonin and/or norepinephrine releasing agent. See also * 3,4-Dichloroamphetamine * Cericlamine * Chlorphentermine Chlorphentermine (trade names Apsedon, Desopimon, Lucofen) is a serotonergic appetite suppressant of the amphetamine family. Developed in 1962, it is the 4-chloro derivative of the better known appetite suppressant phentermine, which is still in ... * Cloforex * Etolorex * Methylenedioxyphentermine * Phentermine References Anorectics Chloroarenes Monoamine releasing agents Substituted amphetamines {{Nervous-sys ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3,4-Dichloroamphetamine
3,4-Dichloroamphetamine (DCA), is an amphetamine derived drug invented by Eli Lilly and Company, Eli Lilly in the 1960s, which has a number of pharmacological actions. It acts as a highly potent and binding selectivity, selective selective serotonin releasing agent, serotonin releasing agent (SSRA) and binds to the serotonin transporter with high affinity, but also acts as a selective serotonergic neurotoxin in a similar manner to the related para-chloroamphetamine, though with slightly lower potency. It is also a monoamine oxidase inhibitor (MAOI), as well as a very potent inhibitor of the enzyme phenylethanolamine N-methyl transferase which normally functions to transform noradrenaline into adrenaline in the body. Synthesis The reaction of 3,4-Dichlorobenzyl Chloride [102-47-6] (1) with cyanide anion gives 3,4-Dichlorophenylacetonitrile [3218-49-3] (2). Reaction with sodium methoxide and ethylacetate gives Alpha-Acetoxy-3,4-DichlorobenzeneacetonitrileCID:14318103(3). Removal of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
