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Betahistine
Betahistine, sold under the brand name Serc among others, is an anti-vertigo medication. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms. It was first registered in Europe in 1970 for the treatment of Ménière's disease but current evidence does not support its efficacy in treating it. Medical uses Betahistine was once believed to have some positive effects in the treatment of Ménière's disease and vertigo but more recent evidence casts doubt over its efficacy. There have been studies of the use of betahistine which showed a reduction in symptoms of vertigo and to a lesser extent, tinnitus, in subjects, but conclusive evidence is lacking at present. Oral betahistine has been approved for the treatment of Ménière’s disease and vestibular vertigo in more than 80 countries worldwide, and has been reportedly prescribed more than 130 million patients. However, betahistine has not been approved for marketing in the United States for the past ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histamine H3 Receptor
Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons and control histamine turnover by feedback inhibition of histamine synthesis and release. The H3 receptor has also been shown to presynaptically inhibit the release of a number of other neurotransmitters (i.e. it acts as an inhibitory heteroreceptor) including, but probably not limited to dopamine, GABA, acetylcholine, noradrenaline, histamine and serotonin. The gene sequence for H3 receptors expresses only about 22% and 20% homology with both H1 and H2 receptors respectively. There is much interest in the histamine H3 receptor as a potential therapeutic target because of its involvement in the neuronal mechanism behind many cognitive disorders and especially its location in the central nervous system.Rapanelli, Maximiliano. “The Magnificent Two: Histamine and the H3 Receptor as Key Modula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |