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Amrinone
Amrinone, also known as inamrinone, and sold as Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may improve the prognosis in patients with congestive heart failure. Amrinone has been shown to increase the contractions initiated in the heart by high-gain calcium induced calcium release (CICR). The positive inotropic effect of amrinone is mediated by the selective enhancement of high-gain CICR, which contributes to the contraction of myocytes by phosphorylation through cAMP dependent protein kinase A (PKA) and Ca2+ calmodulin kinase pathways. Actions Increases cardiac contractility, vasodilator. Acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase (PDE3) enzyme. There is a long-standing controversy regarding whether the drug actually increases cardiac contractility in diseased myocardium (and therefore whether it is of any clinical use). The issue has been reviewed extensively by Dr Peter Wilmshurst, one of the first cardiologists a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peter Wilmshurst
Peter Wilmshurst is a British medical doctor and successful whistleblower who has been the subject of multiple cases of harassment through vexatious litigation, vexatious libel actions brought by companies whose products he criticised as ineffective. He has also reported at least twenty doctors to the General Medical Council in the course of two decades of investigating research misconduct. Background Sterling-Winthrop case In 1986, Wilmshurst, a cardiology, cardiologist then working at St. Thomas' Hospital, London, approached ''The Guardian'' newspaper with a substantial dossier detailing alleged misconduct in the development of Amrinone, a cardiac drug manufactured by Sterling-Winthrop. The drug was supported by a study at Harvard Medical School and published in the New England Journal of Medicine, whose lead author was Eugene Braunwald, a leader in his field. Wilmshurst's group ran a series of experiments on the promising new drug but found no effect on contractility and fre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
