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Amatoxin
Amatoxin is the collective name of a subgroup of at least nine related toxic compounds found in three genera of poisonous mushrooms (''Amanita'', '' Galerina'' and '' Lepiota'') and one species ( Conocybe filaris) of the genus '' Conocybe''. Amatoxins are lethal in even small doses, as little as half a mushroom, including the immature 'egg' form which appears quite different from the fully-grown mushroom. Although laboratory analysis has found that the spores contain as little as 3% the toxin concentration of the main mushroom body, anecdotes have been repeated in field guides that claim foragers have fallen ill from spores alone after collecting but then discarding toxic Amanitas, unknowingly leaving their spore dust on the remaining harvest. Unlike many ingested poisons, they cannot be destroyed by heat without destroying the mushrooms beyond edibility first, so cooking the poisonous mushrooms does not diminish their lethality. Structure The compounds have a similar structure, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amatoxins Generic Strucuture
Amatoxin is the collective name of a subgroup of at least nine related toxic compounds found in three genera of poisonous mushrooms (''Amanita'', ''Galerina'' and ''Lepiota'') and one species ( Conocybe filaris) of the genus '' Conocybe''. Amatoxins are lethal in even small doses, as little as half a mushroom, including the immature 'egg' form which appears quite different from the fully-grown mushroom. Although laboratory analysis has found that the spores contain as little as 3% the toxin concentration of the main mushroom body, anecdotes have been repeated in field guides that claim foragers have fallen ill from spores alone after collecting but then discarding toxic Amanitas, unknowingly leaving their spore dust on the remaining harvest. Unlike many ingested poisons, they cannot be destroyed by heat without destroying the mushrooms beyond edibility first, so cooking the poisonous mushrooms does not diminish their lethality. Structure The compounds have a similar structure, t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lepiota
''Lepiota'' is a genus of gilled mushrooms in the family Agaricaceae. All ''Lepiota'' species are ground-dwelling saprotrophs with a preference for rich, calcareous soils. Basidiocarps (fruit bodies) are agaricoid with whitish spores, typically with scaly caps and a ring on the stipe. Around 400 species of ''Lepiota'' are currently recognized worldwide. Many species are poisonous, some lethally so. Taxonomy History ''Agaricus'' section ''Lepiota'' was originally published in 1797 by South African-born mycologist Christian Hendrik Persoon. It was subsequently raised to the rank of genus by Samuel Frederick Gray. As originally conceived, the genus was a mix of agarics with rings on their stems, including species now placed in ''Armillaria'', ''Cortinarius'', and ''Pholiota''. In 1822, however, the influential Swedish mycologist Elias Magnus Fries restricted ''Lepiota'' to white-spored, ringed agarics. Based on macro- and micromorphology, later authors gradually refined the gene ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proamanullin
Promanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in the mushroom genus ''Amanita''. Toxicology Like other amatoxins, proamanullin is an inhibitor of RNA polymerase II. Promanullin has a specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocyte A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 80% of the liver's mass. These cells are involved in: * Protein synthesis * Protein storage * Transformation of carbohydrates * Synthesis of cholesterol, ...s (liver cells). See also * Mushroom poisoning References External linksAmatoxins REVISED {{Toxins Peptides Amatoxins Hepatotoxins Tryptamines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amanin
Amanin is a cyclic peptide. It is one of the amatoxins, all of which are found in several members of the mushroom genus ''Amanita''. Toxicology Like other amatoxins, amanin is an inhibitor of RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme which completely prevents mRNA synthesis, effectively causing cytolysis of hepatocyte A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 80% of the liver's mass. These cells are involved in: * Protein synthesis * Protein storage * Transformation of carbohydrates * Synthesis of cholesterol, ...s (liver cells) and kidney cells. See also * Mushroom poisoning References {{Toxins Peptides Amatoxins Hepatotoxins Tryptamines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amaninamide
Amaninamide is a cyclic peptide. It is one of the amatoxins, all of which are found in several members of the mushroom genera ''Amanita'', ''Lepiota'' and ''Galerina''. It differs from alpha-amanitin in lacking the hydroxyl group on tryptophan. This alters its UV absorption spectrum but not its toxicity. Toxicology Like other amatoxins, amaninamide is an inhibitor of RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme which completely prevents mRNA synthesis, effectively causing cytolysis of hepatocyte A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 80% of the liver's mass. These cells are involved in: * Protein synthesis * Protein storage * Transformation of carbohydrates * Synthesis of cholesterol, ...s (liver cells) and kidney cells. See also * Mushroom poisoning References External linksAmatoxins REVISED [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amanullin
Amanullin is a cyclic peptide. It is an amatoxin, all of which are found in several members of the mushroom genus ''Amanita''. The oral of amanullin is approximately 20 mg/kg in mice; however, it is non-toxic in humans. Toxicology Like other amatoxins, amanullin is an inhibitor of RNA polymerase II. Amanullin has a species dependent and specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocyte A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 80% of the liver's mass. These cells are involved in: * Protein synthesis * Protein storage * Transformation of carbohydrates * Synthesis of cholesterol, ...s (liver cells). See also * Mushroom poisoning References External linksAmatoxins REVISED (German) {{Toxins [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amanullinic Acid
Amanullinic acid is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the mushroom genus ''Amanita''. Amanullinic acid is relatively non-toxic( oral >20 mg/kg in mice). Toxicology Like other amatoxins, amanullinic acid is an inhibitor of RNA polymerase II RNA polymerase II (RNAP II and Pol II) is a multiprotein complex that transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNAP enzymes found in the nucleus of eukaryo .... See also * Mushroom poisoning References External linksAmatoxins REVISED {{Toxins Peptides Amatoxins Hepatotoxins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heinrich Otto Wieland
Heinrich Otto Wieland (; 4 June 1877 – 5 August 1957) was a German chemist. He won the 1927 Nobel Prize in Chemistry for his research into the bile acids. Career In 1901 Wieland received his doctorate at the University of Munich while studying under Johannes Thiele. In 1904 he completed his habilitation, then continued to teach at the university and starting in 1907 was a consultant for Boehringer Ingelheim. In 1914 he became associate professor for special topics in organic chemistry, and director of the Organic Division of the State Laboratory in Munich. From 1917 to 1918 Wieland worked in the service of the (KWI) Kaiser Wilhelm Institute for Physical Chemistry and Electrochemistry in Dahlem then led by Fritz Haber as an alternative to regular military service. There he was involved in weapons research for instance finding new synthetic routes for mustard gas. He is also credited with the first synthesis of Adamsite. From 1913 to 1921, he was Professor at the Technica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA Polymerase II
RNA polymerase II (RNAP II and Pol II) is a multiprotein complex that transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNAP enzymes found in the nucleus of eukaryotic cells. A 550 kDa complex of 12 subunits, RNAP II is the most studied type of RNA polymerase. A wide range of transcription factors are required for it to bind to upstream gene promoters and begin transcription. Discovery Early studies suggested a minimum of two RNAPs: one which synthesized rRNA in the nucleolus, and one which synthesized other RNA in the nucleoplasm, part of the nucleus but outside the nucleolus. In 1969, science experimentalists Robert Roeder and William Rutter definitively discovered an additional RNAP that was responsible for transcription of some kind of RNA in the nucleoplasm. The finding was obtained by the use of ion-exchange chromatography via DEAE coated Sephadex beads. The technique separated the enz ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amanita
The genus ''Amanita'' contains about 600 species of agarics, including some of the most toxic known mushrooms found worldwide, as well as some well-regarded edible species. This genus is responsible for approximately 95% of the fatalities resulting from mushroom poisoning, with the death cap accounting for about 50% on its own. The most potent toxin present in these mushrooms is α-Amanitin. The genus also contains many edible mushrooms, but mycologists discourage mushroom hunters, other than experts, from selecting any of these for human consumption. Nonetheless, in some cultures, the larger local edible species of ''Amanita'' are mainstays of the markets in the local growing season. Samples of this are '' Amanita zambiana'' and other fleshy species in central Africa, '' A. basii'' and similar species in Mexico, '' A. caesarea'' and the "Blusher" '' Amanita rubescens'' in Europe, and '' A. chepangiana'' in South-East Asia. Other species are used for colouring sauces, such as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Galerina
''Galerina'' is a genus of small brown-spore saprobic fungi (colloquially often ''mushrooms''), with over 300 species found throughout the world from the far north to remote Macquarie Island in the Southern Ocean. The genus is most noted for some extremely poisonous species which are occasionally confused with hallucinogenic species of ''Psilocybe''. Species are typically small and hygrophanous, with a slender and brittle stem. They are often found growing on wood, and when on the ground have a preference for mossy habitats. ''Galerina'' means ''helmet-like''. Taxonomic definition The genus ''Galerina'' is defined as small mushrooms of mycenoid stature, that is, roughly similar in form to ''Mycena'' species: a small conical to bell-shaped cap, and gills attached to a long and slender cartilaginous stem. Species have a pileipellis that is a cutis, and ornamented spores that are brown in deposit, where the spore ornamentation comes from an extra spore covering. Description ''Ga ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
