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17α-Epiestriol
17α-Epiestriol, or simply 17-epiestriol, also known as 16α-hydroxy-17α-estradiol or estra-1,3,5(10)-triene-3,16α,17α-triol, is a minor and weak endogenous estrogen, and the 17α-epimer of estriol (which is 16α-hydroxy-17β-estradiol). It is formed from 16α-hydroxyestrone. In contrast to other endogenous estrogens like estradiol, 17α-epiestriol is a selective agonist of the ERβ. It is described as a relatively weak estrogen, which is in accordance with its relatively low affinity for the ERα. 17α-Epiestriol has been found to be approximately 400-fold more potent than estradiol in inhibiting tumor necrosis factor α (TNFα)-induced vascular cell adhesion molecule 1 (VCAM-1) expression ''in vitro''. See also * Epimestrol * 16β,17α-Epiestriol * 16β-Epiestriol * 17α-Estradiol * 2-Methoxyestradiol 2-Methoxyestradiol (2-ME2, 2-MeO-E2) is a natural metabolite of estradiol and 2-hydroxyestradiol (2-OHE2). It is specifically the 2-methyl ether of 2-hydroxyestra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
16β-Epiestriol
Epiestriol () (brand names Actriol, Arcagynil, Klimadoral), or epioestriol (), also known as 16β-epiestriol or simply 16-epiestriol as well as 16β-hydroxy-17β-estradiol, is a minor and weak endogenous estrogen (medication), estrogen, and the 16β-epimer of estriol (which is 16α-hydroxy-17β-estradiol). Epiestriol is (or has previously been) used clinically in the treatment of acne. In addition to its estrogenic actions, epiestriol has been found to possess significant anti-inflammatory properties without glycogenesis, glycogenic activity or immunosuppressive effects, an interesting finding that is in contrast to conventional anti-inflammatory steroids like hydrocortisone (a glucocorticoid). See also * 17α-Epiestriol * 16β,17α-Epiestriol * Epimestrol * Mytatrienediol References Anti-acne preparations Anti-inflammatory agents Estranes Estrogens Hormones of the hypothalamus-pituitary-gonad axis Sex hormones {{Genito-urinary-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |