white-footed mouse

The white-footed mouse (''Peromyscus leucopus'') is a rodent native to North America from Ontario, Quebec, Labrador, and the Maritime Provinces (excluding the island of Newfoundland) to the southwestern United States and Mexico. In the Maritimes, its only location is a disjunct population in southern Nova Scotia. It is also known as the woodmouse, particularly in Texas.

Description

Adults are in length, not counting the tail, which can add another . A young adult weighs . While their maximum lifespan is 96 months, the mean life expectancy for the species is 45.5 months for females and 47.5 for males. In northern climates, the average life expectancy is 12–24 months. The species is similar to ''Peromyscus maniculatus''.

White-footed Mouse, Quetico.jpg, In Quetico Provincial Park, Ontario
File:Rhus typhina-Peromyscus leucopus-female.jpg, Female on a staghorn sumac

Behavior and diet

White-footed mice are omnivorous, and eat seeds and insects. They are timid and generally avoid humans, but they occasionally take up residence in ground-floor walls of homes and apartments, where they build nests and store food. White-footed mice also takes unoccupied old bird nests to build roofs to live their rest of their lives up in the trees.

Diseases

Like the North American deer mouse, this species may carry hantaviruses, which cause severe illness in humans. It has also been found to be a competent reservoir for the Lyme disease–causing spirochete, '' Borrelia burgdorferi''. The white-footed mouse is the favored host for the parasitic botfly ''Cuterebra fontinella''.

Interactions with humans

The white-footed mouse is one of the most common mouse species used as laboratory mice after the house mouse, and their domesticated version is called '' Peromyscus leucopus linville''. Such domesticated mice are also kept as pets and have been bred to have many different colors.

Adaptations to urbanization in New York City

Native populations of ''P. leucopus'' in New York city are isolated by dense human infrastructure and are largely confined to small urban forest islands such as Prospect Park and Central Park. The limited gene flow caused by human activities and coupled with a bottleneck event in urban populations has been powerful enough to lead to evolutionary divergence of urban white-footed mice.

Metabolism

New York City mice exhibit local adaptations to diet-mediated selective pressures of urban habitats. Being opportunistic feeders, urban ''P. leucopus'' populations subside on food discarded by humans as a readily available source of nutriment, thereby consuming a lot more fat and carbohydrates than rural populations. Results of a landscape genomics study showed evidence of positive selection in mitochondrial genes of urban mice that are responsible for lipid and carbohydrate breakdown and digestion. Isolated ''P. leucopus'' populations inhabiting NYC parks show signs of molecular-level adaptation to urban food resources. The differential evolution of metabolic processes in urban ''P. leucopus'' populations is thought to contribute to their success and survival in NYC urban forests. Furthermore, the morphology of urban white-footed mice may be changing to adapt to alternative food sources. For instance, the teeth of white-footed mice in New York City are shorter than the teeth of rural mice. This change in physical traits could be explained by the availability of higher-quality food sources in urban forests, which negates the need for long, powerful teeth.

Detoxification

Urban populations of ''P. leucopus'' may be under unique selective pressures due to increased routine exposure to pollutants and toxins. A comparative transcriptome study found evidence of positive selection acting on the genes of urban mice that play major roles in detoxification and xenobiotic metabolism. The genes under positive selection pressure include CYPA1A and Hsp90, which are known to be involved in the metabolism of foreign substances and drugs. High concentrations of heavy metals such as lead and mercury in NYC park soils pose a unique selective pressure that likely led urban populations of ''P. leucopus'' to develop metabolic adaptations to the toxicity of urban forest environments. Furthermore, exposure of pollutants is known to induce hypermethylation of DNA''.'' A study showed that in urban white-footed mice, a gene coding for a demethylase enzyme is under positive selection. This means that urban populations of white-food mice that live in highly polluted environments uniquely benefit from an active demethylase enzyme that removes methyl groups from DNA.

Reproduction

City-dwelling white-footed mouse populations are densely concentrated in isolated urban parks, which makes sperm competition a particularly powerful source of selection in urban environments. Genetic studies have identified signs of molecular-level evolution of reproductive processes in urban white-footed mouse populations. Genes associated with spermatogenesis, sperm locomotion, and sperm-egg interactions in urban mice show a divergent pattern of regulation compared to their rural counterparts. Therefore, the intensified sperm competition of dense mouse populations in urban forests has driven them to develop faster, more efficient sperm than that of rural mice.

Immunity

Urban environments are saturated with large numbers of novel and familiar pathogens that are introduced by transportation, traffic, and trade. The elevated occurrence of pathogens is a driver of directional selection in which genetic variants that more efficiently resist infection are favored. The outcome of this selection can be seen in genetic divergence between urban and rural ''P. leucopus'' populations at loci that regulate the innate immune response and inflammation. Furthermore, a study has found evidence of positive selection acting on genes that modulate pathogen recognition in urban mice. Immunoregulatory proteins that are found on T lymphocytes are overexpressed in urban mice when compared to rural populations. These findings suggest that the immune systems of NYC white-footed mice may be evolving to recognize and respond to pathogens more efficiently. The divergence between rural and urban white-footed mice is especially prominent due to impeded gene flow between these populations, which is caused by landscape barriers including roads, highways, and pedestrian sidewalks. Monitoring the strength of immune defenses in ''P. leucopus'' is of special importance because they are commonly infected with dangerous pathogens such as hantaviruses and '' Borrelia burgdorferi''.

See also

* Monongahela virus

References

General references

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* Ostfeld RS, Miller MC & Hazler KR (1996) Causes and consequences of tick (''Ixodes scapularis'') burdens on white-footed mice (''Peromyscus leucopus''). J Mammal ; 77:266–273.
* Ostfeld RS, Schauber EM, Canham CD, Keesing F & al. (2001) Effects of acorn production and mouse abundance on abundance and ''Borrelia burgdorferi'' infection prevalence of nymphal ''Ixodes scapularis'' ticks. Vector Borne Zoonot Dis ; 1:55–63
* Pederson AB, Grieves TJ (2008) 'he interaction of parasites and resource cause crashes in wild mouse population. J Anim Ecol ; 77:370–377
* Schwan, TG, Burgdorfer, W, Schrumpf, ME, Karstens, RH. (1988
The urinary bladder, a consistent source of ''Borrelia burgdorferi'' in experimentally infected white-footed mice (''Peromyscus leucopus'')
J Clin Microbiol ; 26:893–895
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External links

State University of New York, College of Environmental Science and Forestry

White-footed Mouse
CanadianFauna.com


Canadian Biodiversity Website
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{{Taxonbar, from=Q732863

Mammals described in 1818
Peromyscus
Taxa named by Constantine Samuel Rafinesque