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The stratum intermedium in a developing tooth is a layer of two or three
cells Cell most often refers to: * Cell (biology), the functional basic unit of life Cell may also refer to: Locations * Monastic cell, a small room, hut, or cave in which a religious recluse lives, alternatively the small precursor of a monastery w ...
between the inner enamel epithelium and the newly forming cells of the stellate reticulum. It first appears during the early bell stage of tooth development, at around the 14th week of intrauterine life. These cells are closely attached by desmosomes and gap junctions .The stratum intermedium has a notably high
alkaline phosphatase The enzyme alkaline phosphatase (EC 3.1.3.1, alkaline phosphomonoesterase; phosphomonoesterase; glycerophosphatase; alkaline phosphohydrolase; alkaline phenyl phosphatase; orthophosphoric-monoester phosphohydrolase (alkaline optimum), systematic ...
activity. This layer, along with the inner enamel epithelium, is responsible for the
tooth enamel Tooth enamel is one of the four major tissues that make up the tooth in humans and many other animals, including some species of fish. It makes up the normally visible part of the tooth, covering the crown. The other major tissues are dentin, ...
formation Formation may refer to: Linguistics * Back-formation, the process of creating a new lexeme by removing or affixes * Word formation, the creation of a new word by adding affixes Mathematics and science * Cave formation or speleothem, a secondar ...
. It is a part of the dental (enamel) organ. Stratum intermedium stores glycogen. It is absent in the part of the tooth germ that outlines the root portions of the tooth which does not form enamel.


References

*Cate, A.R. Ten. Oral Histology: development, structure, and function. 5th ed. 1998. . * BKB Berkovitz, GR Holland, BJMoxham. Oral Anatomy Histology and Embryology. 3rd edition. Mosby Tooth development {{Tooth development