Nitrogen-13 (¹³N) is a

radioisotope A radionuclide (radioactive nuclide, radioisotope or radioactive isotope) is a nuclide that has excess numbers of either neutrons or protons, giving it excess nuclear energy, and making it unstable. This excess energy can be used in one of three ...

nitrogen Nitrogen is a chemical element; it has Symbol (chemistry), symbol N and atomic number 7. Nitrogen is a Nonmetal (chemistry), nonmetal and the lightest member of pnictogen, group 15 of the periodic table, often called the Pnictogen, pnictogens. ...

used in

positron emission tomography Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, r ...

(PET). It has a

half-life Half-life is a mathematical and scientific description of exponential or gradual decay. Half-life, half life or halflife may also refer to: Film * Half-Life (film), ''Half-Life'' (film), a 2008 independent film by Jennifer Phang * ''Half Life: ...

of a little under ten minutes, so it must be made at the PET site. A

cyclotron A cyclotron is a type of particle accelerator invented by Ernest Lawrence in 1929–1930 at the University of California, Berkeley, and patented in 1932. Lawrence, Ernest O. ''Method and apparatus for the acceleration of ions'', filed: Januar ...

may be used for this purpose. Nitrogen-13 is used to tag

ammonia Ammonia is an inorganic chemical compound of nitrogen and hydrogen with the chemical formula, formula . A Binary compounds of hydrogen, stable binary hydride and the simplest pnictogen hydride, ammonia is a colourless gas with a distinctive pu ...

molecules for PET

myocardial perfusion imaging Myocardial perfusion imaging or scanning (also referred to as MPI or MPS) is a nuclear medicine procedure that illustrates the function of the heart muscle (myocardium). It evaluates many heart conditions, such as coronary artery disease (CAD), ...

Production

Nitrogen-13 is used in medical PET imaging in the form of ¹³N-labelled ammonia. It can be produced with a medical cyclotron, using a target of pure water with a trace amount of ethanol. The reactants are oxygen-16 (present as H₂O) and a proton, and the products are nitrogen-13 and an alpha particle (helium-4). :¹H + ¹⁶O → ¹³N + ⁴He The proton must be accelerated to have total energy greater than 5.66 MeV. This is the threshold energy for this reaction, as it is

endothermic An endothermic process is a chemical or physical process that absorbs heat from its surroundings. In terms of thermodynamics, it is a thermodynamic process with an increase in the enthalpy (or internal energy ) of the system.Oxtoby, D. W; Gillis, ...

(i.e., the mass of the products is greater than the reactants, so energy needs to be supplied which is converted to mass). For this reason, the proton needs to carry extra

energy Energy () is the physical quantity, quantitative physical property, property that is transferred to a physical body, body or to a physical system, recognizable in the performance of Work (thermodynamics), work and in the form of heat and l ...

to induce the

nuclear reaction In nuclear physics and nuclear chemistry, a nuclear reaction is a process in which two atomic nucleus, nuclei, or a nucleus and an external subatomic particle, collide to produce one or more new nuclides. Thus, a nuclear reaction must cause a t ...

. The energy difference is actually 5.22 MeV, but if the proton only supplied this energy, the reactants would be formed with no

kinetic energy In physics, the kinetic energy of an object is the form of energy that it possesses due to its motion. In classical mechanics, the kinetic energy of a non-rotating object of mass ''m'' traveling at a speed ''v'' is \fracmv^2.Resnick, Rober ...

. As

momentum In Newtonian mechanics, momentum (: momenta or momentums; more specifically linear momentum or translational momentum) is the product of the mass and velocity of an object. It is a vector quantity, possessing a magnitude and a direction. ...

must be conserved, the true energy that needs to be supplied by the proton is given by: :

K =(1+m/M) , E,

where

m

is the mass of ⁴He and

M

is the mass of ¹³N ; therefore . The presence of ethanol (at a concentration of ~5mM) in aqueous solution allows the convenient formation of ammonia as nitrogen-13 is produced. Other routes of producing ¹³N-labelled ammonia exist, some of which facilitate co-generation of other light radionuclides for diagnostic imaging.

Nitrogen-13 plays a significant role in the

CNO cycle In astrophysics, the carbon–nitrogen–oxygen (CNO) cycle, sometimes called Bethe–Weizsäcker cycle, after Hans Albrecht Bethe and Carl Friedrich von Weizsäcker, is one of the two known sets of fusion reactions by which stars convert h ...

, which is the dominant source of energy in main-sequence stars more massive than 1.5 times the

mass Mass is an Intrinsic and extrinsic properties, intrinsic property of a physical body, body. It was traditionally believed to be related to the physical quantity, quantity of matter in a body, until the discovery of the atom and particle physi ...

of the

Sun The Sun is the star at the centre of the Solar System. It is a massive, nearly perfect sphere of hot plasma, heated to incandescence by nuclear fusion reactions in its core, radiating the energy from its surface mainly as visible light a ...

. Lightning may have a role in the production of nitrogen-13.

External links

PET site
of the

University of Melbourne The University of Melbourne (colloquially known as Melbourne University) is a public university, public research university located in Melbourne, Australia. Founded in 1853, it is Australia's second oldest university and the oldest in the state ...

References

{{Isotope sequence , element=nitrogen , lighter= nitrogen-12 , heavier=

nitrogen-14 Natural nitrogen (7N) consists of two stable isotopes: the vast majority (99.6%) of naturally occurring nitrogen is nitrogen-14, with the remainder being nitrogen-15. Thirteen radioisotopes are also known, with atomic masses ranging from 9 to 23, ...

, before= oxygen-13 (

electron capture Electron capture (K-electron capture, also K-capture, or L-electron capture, L-capture) is a process in which the proton-rich nucleus of an electrically neutral atom absorbs an inner atomic electron, usually from the K or L electron shells. Th ...

) , after=

carbon-13 Carbon-13 (13C) is a natural, stable isotope of carbon with a nucleus containing six protons and seven neutrons. As one of the environmental isotopes, it makes up about 1.1% of all natural carbon on Earth. Detection by mass spectrometry A m ...

(EC) Isotopes of nitrogen Positron emitters Medical isotopes