The keratinocyte growth factor (KGF), also known as
FGF7, is a
growth factor present in the
epithelialization
Wound healing refers to a living organism's replacement of destroyed or damaged tissue by newly produced tissue.
In undamaged skin, the epidermis (surface, epithelial layer) and dermis (deeper, connective layer) form a protective barrier agains ...
-phase of
wound healing
Wound healing refers to a living organism's replacement of destroyed or damaged tissue by newly produced tissue.
In undamaged skin, the epidermis (surface, epithelial layer) and dermis (deeper, connective layer) form a protective barrier agains ...
. In this phase,
keratinocytes are covering the wound, forming the
epithelium.
KGF is a small signaling molecule that binds to
fibroblast growth factor receptor 2b
Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the ''FGFR2'' gene residing on chromosome 10. FGFR2 is a receptor for fibroblast growth factor.
The prote ...
(FGFR2b).
[ ] For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin.
There are 23 known FGFs, and 4
FGF receptor FGF may refer to:
* , the Football Federation of Rio Grande do Sul, Brazil
* , the Football Federation of Goiás, Brazil
* Fibroblast growth factor
* Galician Football Federation (Spanish: '), in Spain
* Guinean Football Federation
The Guinean F ...
s. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner.
FGF10 is also known as "keratinocyte growth factor 2".
[FGF10 >]
See also
*
Palifermin
Palifermin (trade name Kepivance, marketed by Biovitrum) is a truncated human recombinant keratinocyte growth factor (KGF) produced in ''Escherichia coli''. KGF stimulates the growth of cells that line the surface of the mouth and intestinal t ...
References
External links
FGF 2-FGFR 1c-Heparin (2:2:2) Complex
Growth factors
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