foot-and-mouth disease
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Foot-and-mouth disease (FMD) or hoof-and-mouth disease (HMD) is an infectious and sometimes fatal viral
disease A disease is a particular abnormal condition that adversely affects the structure or function (biology), function of all or part of an organism and is not immediately due to any external injury. Diseases are often known to be medical condi ...
that primarily affects even-toed ungulates, including domestic and wild
bovid The Bovidae comprise the family (biology), biological family of cloven-hoofed, ruminant mammals that includes Bos, cattle, bison, Bubalina, buffalo, antelopes (including Caprinae, goat-antelopes), Ovis, sheep and Capra (genus), goats. A member o ...
s. The virus causes a high fever lasting two to six days, followed by
blisters A blister is a small pocket of body fluid (lymph, Serum (blood), serum, Plasma (blood), plasma, blood, or pus) within the Epidermis, upper layers of the skin, usually caused by forceful rubbing (friction), burning, freezing, chemical exposure o ...
inside the mouth and near the hoof that may rupture and cause
lameness A limp is a type of asymmetric abnormality of the gait. Limping may be caused by pain, weakness, neuromuscular imbalance, or a skeletal deformity. The most common underlying cause of a painful limp is physical trauma; however, in the absence ...
. FMD has very severe implications for animal farming, since it is highly infectious and can be spread by infected animals comparatively easily through contact with contaminated farming equipment, vehicles, clothing, and feed, and by domestic and wild
predator Predation is a biological interaction in which one organism, the predator, kills and eats another organism, its prey. It is one of a family of common List of feeding behaviours, feeding behaviours that includes parasitism and micropredation ...
s. Its containment demands considerable efforts in
vaccination Vaccination is the administration of a vaccine to help the immune system develop immunity from a disease. Vaccines contain a microorganism or virus in a weakened, live or killed state, or proteins or toxins from the organism. In stimulating ...
, strict monitoring,
trade restriction A trade restriction is an artificial restriction on the trade of goods and/or services between two or more countries. It is the byproduct of protectionism. However, the term is controversial because what one part may see as a trade restriction ...
s,
quarantine A quarantine is a restriction on the movement of people, animals, and goods which is intended to prevent the spread of disease or pests. It is often used in connection to disease and illness, preventing the movement of those who may have bee ...
s, and the
culling Culling is the process of segregating organisms from a group according to desired or undesired characteristics. In animal breeding, it is removing or segregating animals from a breeding stock based on a specific trait. This is done to exagge ...
of both infected and healthy (uninfected) animals. Susceptible animals include
cattle Cattle (''Bos taurus'') are large, domesticated, bovid ungulates widely kept as livestock. They are prominent modern members of the subfamily Bovinae and the most widespread species of the genus '' Bos''. Mature female cattle are calle ...
,
water buffalo The water buffalo (''Bubalus bubalis''), also called domestic water buffalo, Asian water buffalo and Asiatic water buffalo, is a large bovid originating in the Indian subcontinent and Southeast Asia. Today, it is also kept in Italy, the Balkans ...
,
sheep Sheep (: sheep) or domestic sheep (''Ovis aries'') are a domesticated, ruminant mammal typically kept as livestock. Although the term ''sheep'' can apply to other species in the genus '' Ovis'', in everyday usage it almost always refers to d ...
,
goat The goat or domestic goat (''Capra hircus'') is a species of Caprinae, goat-antelope that is mostly kept as livestock. It was domesticated from the wild goat (''C. aegagrus'') of Southwest Asia and Eastern Europe. The goat is a member of the ...
s, pigs,
antelope The term antelope refers to numerous extant or recently extinct species of the ruminant artiodactyl family Bovidae that are indigenous to most of Africa, India, the Middle East, Central Asia, and a small area of Eastern Europe. Antelopes do ...
,
deer A deer (: deer) or true deer is a hoofed ruminant ungulate of the family Cervidae (informally the deer family). Cervidae is divided into subfamilies Cervinae (which includes, among others, muntjac, elk (wapiti), red deer, and fallow deer) ...
, and
bison A bison (: bison) is a large bovine in the genus ''Bison'' (from Greek, meaning 'wild ox') within the tribe Bovini. Two extant taxon, extant and numerous extinction, extinct species are recognised. Of the two surviving species, the American ...
. It has also been known to infect
hedgehog A hedgehog is a spiny mammal of the subfamily Erinaceinae, in the eulipotyphlan family Erinaceidae. There are 17 species of hedgehog in five genera found throughout parts of Europe, Asia, and Africa, and in New Zealand by introduction. The ...
s and
elephant Elephants are the largest living land animals. Three living species are currently recognised: the African bush elephant ('' Loxodonta africana''), the African forest elephant (''L. cyclotis''), and the Asian elephant ('' Elephas maximus ...
s;
llama The llama (; or ) (''Lama glama'') is a domesticated South American camelid, widely used as a List of meat animals, meat and pack animal by Inca empire, Andean cultures since the pre-Columbian era. Llamas are social animals and live with ...
s and
alpaca The alpaca (''Lama pacos'') is a species of South American camelid mammal. Traditionally, alpacas were kept in herds that grazed on the level heights of the Andes of Southern Peru, Western Bolivia, Ecuador, and Northern Chile. More recentl ...
s may develop mild symptoms, but are resistant to the disease and do not pass it on to others of the same species. In laboratory experiments,
mice A mouse (: mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus' ...
,
rat Rats are various medium-sized, long-tailed rodents. Species of rats are found throughout the order Rodentia, but stereotypical rats are found in the genus ''Rattus''. Other rat genera include '' Neotoma'' (pack rats), '' Bandicota'' (bandicoo ...
s, and
chicken The chicken (''Gallus gallus domesticus'') is a domesticated subspecies of the red junglefowl (''Gallus gallus''), originally native to Southeast Asia. It was first domesticated around 8,000 years ago and is now one of the most common and w ...
s have been artificially infected, but they are not believed to contract the disease under natural conditions. Cattle, Asian and African buffalo, sheep, and goats can become carriers following an acute infection, meaning they are still infected with a small amount of virus but appear healthy. Animals can be carriers for up to 1–2 years and are considered very unlikely to infect other animals, although laboratory evidence suggests that transmission from carriers is possible. Humans are only extremely rarely infected by foot-and-mouth disease virus (FMDV). Humans, particularly young children, can be affected by
hand, foot, and mouth disease Hand, foot, and mouth disease (HFMD) is a common infection caused by a group of enteroviruses. It typically begins with a fever and feeling generally unwell. This is followed a day or two later by flat discolored spots or bumps that may blis ...
(HFMD), which is often confused with FMD. HFMDV also affects cattle, sheep, and swine. HFMD is also a viral infection caused by multiple viruses belonging to the Picornaviridae family, but it is distinct from FMD. The
virus A virus is a submicroscopic infectious agent that replicates only inside the living Cell (biology), cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Viruses are ...
responsible for FMD is an aphthovirus, foot-and-mouth disease virus. Infection occurs when the virus particle is taken into a cell of the host. The cell is then forced to manufacture thousands of copies of the virus, and eventually bursts, releasing the new particles in the blood. The virus is genetically highly variable, which limits the effectiveness of vaccination. The disease was first documented in 1870.


Signs and symptoms

The incubation period for FMD virus has a range between one and 12 days. The disease is characterized by high
fever Fever or pyrexia in humans is a symptom of an anti-infection defense mechanism that appears with Human body temperature, body temperature exceeding the normal range caused by an increase in the body's temperature Human body temperature#Fever, s ...
that declines rapidly after two to three days, blisters inside the mouth that lead to excessive secretion of stringy or foamy saliva and to drooling, and blisters on the feet that may rupture and cause lameness. Adult animals may suffer weight loss from which they do not recover for several months, as well as swelling in the testicles of mature males, and cows'
milk Milk is a white liquid food produced by the mammary glands of lactating mammals. It is the primary source of nutrition for young mammals (including breastfeeding, breastfed human infants) before they are able to digestion, digest solid food. ...
production can decline significantly. Though most animals eventually recover from FMD, the disease can lead to
myocarditis Myocarditis is inflammation of the cardiac muscle. Myocarditis can progress to inflammatory cardiomyopathy when there is associated ventricular remodeling and cardiac dysfunction due to chronic inflammation. Symptoms can include shortness of bre ...
(inflammation of the heart muscle) and death, especially in newborn animals. Some infected ruminants remain
asymptomatic Asymptomatic (or clinically silent) is an adjective categorising the medical conditions (i.e., injuries or diseases) that patients carry but without experiencing their symptoms, despite an explicit diagnosis (e.g., a positive medical test). P ...
carriers, but they nonetheless carry the virus and may be able to transmit it to others. Pigs cannot serve as asymptomatic carriers.


Subclinical infection

Subclinical (asymptomatic) infections can be classified as neoteric or persistent based on when they occur and whether the animal is infectious. Neoteric subclinical infections are acute infections, meaning they occur soon after an animal is exposed to the FMD virus (about 1 to 2 days) and last about 8 to 14 days. Acute infections are characterized by a high degree of replicating virus in the
pharynx The pharynx (: pharynges) is the part of the throat behind the human mouth, mouth and nasal cavity, and above the esophagus and trachea (the tubes going down to the stomach and the lungs respectively). It is found in vertebrates and invertebrates ...
. In a neoteric subclinical infection, the virus remains in the pharynx and does not spread into the blood as it would in a clinical infection. Although animals with neoteric subclinical infections do not appear to have disease, they shed substantial amounts of virus in nasal secretions and saliva, so they are able to transmit the FMD virus to other animals. Neoteric subclinical infections often occur in vaccinated animals but can occur in unvaccinated animals as well. Persistent subclinical infection (also referred to as a carrier state) occurs when an animal recovers from an acute infection but continues to have a small amount of replicating virus present in the pharynx. Cattle, buffalo, sheep, and goats can all become carriers, but pigs cannot. Animals can become carriers following acute infections with or without symptoms. Both vaccinated and unvaccinated animals can become carriers. Transmission of the FMD virus from carriers to susceptible animals is considered very unlikely under natural conditions and has not been conclusively demonstrated in field studies. However, in an experiment where virus was collected from the pharynx of carrier cattle and inserted in the pharynx of susceptible cattle, the susceptible cattle became infected and developed characteristic blisters in the mouth and on the feet. This supports the theory that while the likelihood of a carrier spreading FMD is quite low, it is not impossible. It is not fully understood why ruminants but not pigs can become carriers or why some animals develop persistent infection while others do not. Both are areas of ongoing study. Because vaccinated animals can become carriers, the waiting period to prove FMD-freedom is longer when vaccination rather than slaughter is used as an outbreak-control strategy. As a result, many FMD-free countries are resistant to emergency vaccination in case of in outbreak out of concern for the serious trade and economic implications of a prolonged period without FMD-free status. Although the risk of transmission from an individual FMD carrier is considered to be very low, there are many carriers in FMD-endemic regions, possibly increasing the number of chances for carrier transmission to occur. Also, it can be difficult to determine if an asymptomatic infection is neoteric or persistent in the field, as both would be apparently healthy animals that test positive for the FMD virus. This fact complicates disease control, as the two types of subclinical infections have significantly different risks of spreading disease.


Cause

Of the seven serotypes of this virus, A, C, O, Asia 1, and SAT3 appear to be distinct lineages; SAT 1 and SAT 2 are unresolved clades. The mutation rate of the protein-encoding sequences of strains isolated between 1932 and 2007 has been estimated to be 1.46 × 10−3 substitutions/site/year, a rate similar to that of other RNA viruses. The most recent common ancestor appears to have evolved about 481 years ago (early 16th century). This ancestor then diverged into two clades which have given rise to the extant circulating Euro-Asiatic and South African. SAT 1 diverged first 397 years ago, followed by sequential divergence of serotype SAT 2 (396 years ago), A (147 years ago), O (121 years ago), Asia 1 (89 years ago), C (86 years ago), and SAT 3 (83 years ago). Bayesian skyline plot reveals a population expansion in the early 20th century that is followed by a rapid decline in population size from the late 20th century to the present day. Within each serotype, there was no apparent periodic, geographic, or host species influence on the evolution of global FMD viruses. At least seven genotypes of serotype Asia 1 are known.


Transmission

The FMD virus can be transmitted in a number of ways, including close-contact, animal-to-animal spread, long-distance aerosol spread and
fomite A fomite () or fomes () is any inanimate object that, when contaminated with or exposed to infectious agents (such as pathogenic bacteria, viruses or fungi), can transfer disease to a new host. Transfer of pathogens by fomites A fomite is any ...
s, or inanimate objects, typically fodder and motor vehicles. The clothes and skin of animal handlers such as farmers, standing water, and uncooked food scraps and feed supplements containing infected animal products can harbor the virus, as well. Cows can also catch FMD from the semen of infected bulls. Control measures include quarantine and destruction of both infected and healthy (uninfected) livestock, and export bans for meat and other animal products to countries not infected with the disease. There is significant variation in both susceptibility to infection and ability to spread disease between different species, virus strains, and transmission routes. For example, cattle are far more vulnerable than pigs to infection with aerosolized virus, and infected pigs produce 30 times the amount of aerosolized virus compared to infected cattle and sheep. Also, pigs are particularly vulnerable to infection through the oral route. It has been demonstrated experimentally that FMD can be spread to pigs when they eat commercial feed products contaminated by the FMD virus. Also, the virus can remain active for extended periods of time in certain feed ingredients, especially soybean meal. Feed biosecurity practices have become an important area of study since a 2013 outbreak of Porcine Epidemic Diarrhea Virus (PEDV) in the US, thought to be introduced through contaminated feed. Just as humans may spread the disease by carrying the virus on their clothes and bodies, animals that are not susceptible to the disease may still aid in spreading it. This was the case in Canada in 1952, when an outbreak flared up again after
dog The dog (''Canis familiaris'' or ''Canis lupus familiaris'') is a domesticated descendant of the gray wolf. Also called the domestic dog, it was selectively bred from a population of wolves during the Late Pleistocene by hunter-gatherers. ...
s had carried off bones from dead animals.
Wolves The wolf (''Canis lupus''; : wolves), also known as the grey wolf or gray wolf, is a canine native to Eurasia and North America. More than thirty subspecies of ''Canis lupus'' have been recognized, including the dog and dingo, though gr ...
are thought to play a similar role in the former
Soviet Union The Union of Soviet Socialist Republics. (USSR), commonly known as the Soviet Union, was a List of former transcontinental countries#Since 1700, transcontinental country that spanned much of Eurasia from 1922 until Dissolution of the Soviet ...
. Daniel Rossouw Kannemeyer (1843–1925) published a note in the ''Transactions of the South African Philosophical Society'' volume 8 part 1 in which he links saliva-covered locusts with the spread of the disease. Transmission of the FMD virus is possible before an animal has apparent signs of disease, a factor that increases the risk that significant spread of the virus has occurred before an outbreak is detected. A 2011 experiment measured transmission timing in cattle infected with serotype O virus by exposing susceptible cattle in 24-hour increments. It estimated the infectious period of the infected cattle to be 1.7 days, but showed the cattle were only infectious for a few hours before they developed fevers or classic FMD lesions. The authors also showed that the infectious period would have been estimated to be much higher (4.2 to 8.2 days) if detection of virus had been used as a substitute for infectiousness. A similar 2016 experiment using serotype A virus exposed susceptible pigs to infected pigs for 8 hour periods and found that pigs were able to spread disease for a full day before developing signs of disease. Analysis of this experimental data estimated the infectious period to be approximately 7 days. Again, the study showed that detection of virus was not an accurate substitution for infectiousness. An accurate understanding of the parameters of infectiousness is an important component of building epidemiological models which inform disease control strategies and policies.


Infecting humans

Humans can be infected with FMD through contact with infected animals, but this is extremely rare. Some cases were caused by laboratory accidents. Because the virus that causes FMD is sensitive to stomach acid, it cannot spread to humans via consumption of infected meat, except in the mouth before the meat is swallowed. In the UK, the last confirmed human case occurred in 1966, and only a few other cases have been recorded in countries of
continental Europe Continental Europe or mainland Europe is the contiguous mainland of Europe, excluding its surrounding islands. It can also be referred to ambiguously as the European continent, – which can conversely mean the whole of Europe – and, by som ...
, Africa, and South America. Symptoms of FMD in humans include malaise, fever, vomiting, red ulcerative lesions (surface-eroding damaged spots) of the oral tissues, and sometimes vesicular lesions (small blisters) of the skin. According to a newspaper report, FMD killed two children in England in 1884, supposedly due to infected milk. Another viral disease with similar symptoms, hand, foot and mouth disease, occurs more frequently in humans, especially in young children; certain other non-polio enteroviruses than the FMD virus are its cause. These viruses belong to the ''
Enterovirus ''Enterovirus'' is a genus of positive-sense single-stranded RNA viruses associated with several human and mammalian diseases. Enteroviruses are named by their transmission-route through the intestine ('enteric' meaning intestinal). Serologic ...
'' genus within the ''Picornaviridae''. Because FMD rarely infects humans, but spreads rapidly among animals, it is a much greater threat to the agriculture industry than to human health. It has been argued that FMD is a zoonotic disease, but it is not considered among them by the U.S. Centers for Disease Control and Prevention and the U.S. Department of Agriculture due to the rarity of interspecies transmission.


Prevention

Like other RNA viruses, the FMD virus continually evolves and mutates, thus one of the difficulties in vaccinating against it is the huge variation between, and even within,
serotype A serotype or serovar is a distinct variation within a species of bacteria or virus or among immune cells of different individuals. These microorganisms, viruses, or Cell (biology), cells are classified together based on their shared reactivity ...
s. No cross-protection has been seen between serotypes (a vaccine for one serotype will not protect against any others) and in addition, two strains within a given serotype may have
nucleotide Nucleotides are Organic compound, organic molecules composed of a nitrogenous base, a pentose sugar and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both o ...
sequences that differ by as much as 30% for a given gene. This means FMD
vaccine A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verifi ...
s must be highly specific to the strain involved. Vaccination only provides temporary
immunity Immunity may refer to: Medicine * Immunity (medical), resistance of an organism to infection or disease * ''Immunity'' (journal), a scientific journal published by Cell Press Biology * Immune system Engineering * Radiofrequence immunity ...
that lasts from months to years. Currently, the
World Organisation for Animal Health The World Organisation for Animal Health (WOAH), formerly the (OIE), is an intergovernmental organisation founded in 1924, coordinating, supporting and promoting animal disease control. The primary objective of WOAH is to control epizootic dis ...
recognizes countries to be in one of three disease states with regard to FMD: FMD present with or without vaccination, FMD-free with vaccination, and FMD-free without vaccination. Countries designated FMD-free without vaccination have the greatest access to export markets, so many developed nations, including Canada, the United States, and the UK, work hard to maintain their current status. Some countries such as
Brazil Brazil, officially the Federative Republic of Brazil, is the largest country in South America. It is the world's List of countries and dependencies by area, fifth-largest country by area and the List of countries and dependencies by population ...
and
Argentina Argentina, officially the Argentine Republic, is a country in the southern half of South America. It covers an area of , making it the List of South American countries by area, second-largest country in South America after Brazil, the fourt ...
, which have large beef-exporting industries, practise vaccination in some areas, but have other vaccination-free zones. Reasons cited for restricting export from countries using FMD vaccines include, probably most importantly, routine blood tests relying on antibodies cannot distinguish between an infected and a vaccinated animal, which severely hampers screening of animals used in export products, risking a spread of FMD to importing countries. A widespread preventive vaccination would also conceal the existence of the virus in a country. From there, it could potentially spread to countries without vaccine programs. Lastly, an animal infected shortly after being vaccinated can harbor and spread FMD without showing symptoms itself, hindering containment and culling of sick animals as a remedy. Many early vaccines used dead samples of the FMD virus to inoculate animals, but those early vaccines sometimes caused real outbreaks. In the 1970s, scientists discovered that a vaccine could be made using only a single key
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
from the virus. The task was to produce enough quantities of the protein to be used in the vaccination. On June 18, 1981, the US government announced the creation of a vaccine targeted against FMD, the world's first genetically engineered vaccine. The North American FMD Vaccine Bank is housed at the
United States Department of Agriculture The United States Department of Agriculture (USDA) is an executive department of the United States federal government that aims to meet the needs of commercial farming and livestock food production, promotes agricultural trade and producti ...
's Foreign Animal Disease Diagnostic Laboratory at Plum Island Animal Disease Center. The center, located off the coast of Long Island, New York, is the only place in the United States where scientists can conduct research and diagnostic work on highly contagious animal diseases such as FMD. Because of this limitation, US companies working on FMD usually use facilities in other countries where such diseases are endemic.


Epidemiology


United States (1870–1929)

The US has had nine FMD outbreaks since it was first recognized on the northeastern coast in 1870; the most devastating happened in 1914. It originated from
Michigan Michigan ( ) is a peninsular U.S. state, state in the Great Lakes region, Great Lakes region of the Upper Midwest, Upper Midwestern United States. It shares water and land boundaries with Minnesota to the northwest, Wisconsin to the west, ...
, but its entry into the stockyards in Chicago turned it into an
epizootic In epizoology, an epizootic (or epizoötic, from Greek: ''epi-'' "upon" + ''zoon'' "animal") is a disease event in a nonhuman animal population analogous to an epidemic in humans. An epizootic disease (or ) may occur in a specific locale (an ...
. About 3,500 livestock herds were infected across the US, totaling over 170,000 cattle, sheep, and swine. The eradication came at a cost of US$4.5 million (equivalent to $ million in ). A 1924 outbreak in California resulted not only in the slaughter of 109,000 farm animals, but also 22,000
deer A deer (: deer) or true deer is a hoofed ruminant ungulate of the family Cervidae (informally the deer family). Cervidae is divided into subfamilies Cervinae (which includes, among others, muntjac, elk (wapiti), red deer, and fallow deer) ...
. The US had its latest FMD outbreak in
Montebello, California Montebello (Italian language, Italian for "Beautiful Mountain") is a city in Los Angeles County, California, United States, located just east of East Los Angeles, California, East Los Angeles and southwest of San Gabriel Valley. It is an indepen ...
, in 1929. This outbreak originated in hogs that had eaten infected meat scraps from a tourist steamship that had stocked meat in Argentina. Over 3,600 animals were slaughtered and the disease was contained in less than a month.


Mexico–U.S. border (1947)

On December 26, 1946, the United States and Mexico jointly declared that FMD had been found in Mexico. Initially, proposals from Texans were for an animal-proof wall, to prevent animals from crossing the border and spreading the disease, but the two countries eventually managed to cooperate in a bilateral effort and eradicated the disease without building a wall. To prevent tension between ranchers and the veterinarians, public broadcasts over the radio and with speakers on trucks were used to inform Mexican ranchers why the U.S. veterinarians were working on their livestock. Ranchers who lost cattle due to being culled by the vets would receive financial compensation. However, the tension remained and resulted in clashes between local citizens and the military-protected U.S. veterinarians. These teams of veterinarians worked from outside the infection zone of the disease and worked their way to the heart of the epidemic. Over 60,000,000 injections were administered to livestock by the end of 1950.


United Kingdom (1967)

In October 1967, a farmer in
Shropshire Shropshire (; abbreviated SalopAlso used officially as the name of the county from 1974–1980. The demonym for inhabitants of the county "Salopian" derives from this name.) is a Ceremonial counties of England, ceremonial county in the West M ...
reported a lame sow, which was later diagnosed with FMD. The source was believed to be remains of legally imported infected lamb from Argentina and Chile. The virus spread, and in total, 442,000 animals were slaughtered and the outbreak had an estimated cost of £370 million (equivalent to £ billion in ).


Taiwan (1997)

Taiwan had previous epidemics of FMD in 1913–14 and 1924–29, but had since been spared, and considered itself free of FMD as late as in the 1990s. On the 19th of March 1997, a sow at a farm in
Hsinchu Hsinchu (, ), officially Hsinchu City, is a city located in northwestern Taiwan. It is the most populous city in Taiwan that is not a special municipality, with estimated 450,655 inhabitants. Hsinchu is a coastal city bordering the Taiwan ...
,
Taiwan Taiwan, officially the Republic of China (ROC), is a country in East Asia. The main geography of Taiwan, island of Taiwan, also known as ''Formosa'', lies between the East China Sea, East and South China Seas in the northwestern Pacific Ocea ...
, was diagnosed with a strain of FMD that only infects swine. Mortality was high, nearing 100% in the infected herd. The cause of the epidemic was not determined, but the farm was near a port city known for its pig-smuggling industry and illegal slaughterhouses. Smuggled swine or contaminated meat are thus likely sources of the disease. The disease spread rapidly among swine herds in Taiwan, with 200–300 new farms being infected daily. Causes for this include the high swine density in the area, with up to 6,500 hogs per square mile, feeding of pigs with untreated garbage, and the farms' proximity to slaughterhouses. Other systemic issues, such as lack of laboratory facilities, slow response, and initial lack of a vaccination program, contributed. A complicating factor is the endemic spread of swine vesicular disease (SVD) in Taiwan. The symptoms are indistinguishable from FMD, which may have led to previous misdiagnosing of FMD as SVD. Laboratory analysis was seldom used for diagnosis, and FMD may thus have gone unnoticed for some time. The swine depopulation was a massive undertaking, with the military contributing substantial manpower. At peak capacity, 200,000 hogs per day were disposed of, mainly by
electrocution Electrocution is death or severe injury caused by electric shock from electric current passing through the body. The word is derived from "electro" and "execution", but it is also used for accidental death. The term "electrocution" was coined ...
. Carcasses were disposed of by burning and burial, but burning was avoided in water resource-protection areas. In April, industrial incinerators were running around the clock to dispose of the carcasses. Initially, 40,000 combined vaccine doses for the strains O-1, A-24, and Asia-1 were available and administered to zoo animals and valuable breeding hogs. At the end of March, half a million new doses for O-1 and Asia-1 were made available. On the May 3rd, 13 million doses of O-1 vaccine arrived, and both the March and May shipments were distributed free of charge. With a danger of vaccination crews spreading the disease, only trained farmers were allowed to administer the vaccine under veterinary supervision. Taiwan had previously been the major exporter of pork to Japan, and among the top 15 pork producers in the world in 1996. During the outbreak, over 3.8 million swine were destroyed at a cost of US$6.9 billion (equivalent to $ billion in ). The Taiwanese pig industry was devastated as a result, and the export market was in ruins. In 2007, Taiwan was considered free of FMD, but was still conducting a vaccination program, which restricts the export of meat from Taiwan.


United Kingdom (2001)

The epidemic of FMD in the
United Kingdom The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Northwestern Europe, off the coast of European mainland, the continental mainland. It comprises England, Scotlan ...
in the spring and summer of 2001 was caused by the "Type O pan Asia" strain of the disease. This episode resulted in more than 2,000 cases of the disease in farms throughout the British countryside. More than six million sheep and cattle were killed in an eventually successful attempt to halt the disease. The county of
Cumbria Cumbria ( ) is a ceremonial county in North West England. It borders the Scottish council areas of Dumfries and Galloway and Scottish Borders to the north, Northumberland and County Durham to the east, North Yorkshire to the south-east, Lancash ...
was the most seriously affected area of the country, with 843 cases. By the time the disease was halted in October 2001, the crisis was estimated to have cost Britain £8 billion (equivalent to £ billion in ) to the agricultural and support industries, and to the outdoor industry. What made this outbreak so serious was the amount of time between infection being present at the first outbreak locus, and when countermeasures were put into operation against the disease, such as transport bans and detergent washing of both vehicles and personnel entering livestock areas. The epidemic was probably caused by pigs that had been fed infected rubbish that had not been properly heat-sterilized. Further, the rubbish is believed to have contained remains of infected meat that had been illegally imported to Britain.


China (2005)

In April 2005, an Asia-1 strain of FMD appeared in the eastern provinces of
Shandong Shandong is a coastal Provinces of China, province in East China. Shandong has played a major role in Chinese history since the beginning of Chinese civilization along the lower reaches of the Yellow River. It has served as a pivotal cultural ...
and
Jiangsu Jiangsu is a coastal Provinces of the People's Republic of China, province in East China. It is one of the leading provinces in finance, education, technology, and tourism, with its capital in Nanjing. Jiangsu is the List of Chinese administra ...
. During April and May, it spread to suburban Beijing, the northern province of
Hebei Hebei is a Provinces of China, province in North China. It is China's List of Chinese administrative divisions by population, sixth-most populous province, with a population of over 75 million people. Shijiazhuang is the capital city. It bor ...
, and the
Xinjiang Xinjiang,; , SASM/GNC romanization, SASM/GNC: Chinese postal romanization, previously romanized as Sinkiang, officially the Xinjiang Uygur Autonomous Region (XUAR), is an Autonomous regions of China, autonomous region of the China, People' ...
autonomous region An autonomous administrative division (also referred to as an autonomous area, zone, entity, unit, region, subdivision, province, or territory) is a subnational administrative division or territory, internal territory of a sovereign state that has ...
in
northwest China Northwestern China () is a region in the People's Republic of China. It consists of five provincial administrative regions, namely Shaanxi, Gansu, Qinghai, Ningxia, and Xinjiang. The region is characterized by a (semi-)arid continental climate. ...
. On 13 May, China reported the FMD outbreak to the
World Health Organization The World Health Organization (WHO) is a list of specialized agencies of the United Nations, specialized agency of the United Nations which coordinates responses to international public health issues and emergencies. It is headquartered in Gen ...
and the OIE. This was the first time China has publicly admitted to having FMD. China is still reporting FMD outbreaks. In 2007, reports filed with the OIE documented new or ongoing outbreaks in the provinces of
Gansu Gansu is a provinces of China, province in Northwestern China. Its capital and largest city is Lanzhou, in the southeastern part of the province. The seventh-largest administrative district by area at , Gansu lies between the Tibetan Plateau, Ti ...
,
Qinghai Qinghai is an inland Provinces of China, province in Northwestern China. It is the largest provinces of China, province of China (excluding autonomous regions) by area and has the third smallest population. Its capital and largest city is Xin ...
and
Xinjiang Xinjiang,; , SASM/GNC romanization, SASM/GNC: Chinese postal romanization, previously romanized as Sinkiang, officially the Xinjiang Uygur Autonomous Region (XUAR), is an Autonomous regions of China, autonomous region of the China, People' ...
. This included reports of domestic yak showing signs of infection. FMD is endemic in pastoral regions of China from Heilongjiang Province in the northeast to Sichuan Province and the Tibetan Autonomous region in the southwest. Chinese domestic media reports often use a euphemism "Disease Number Five" (五号病 ''wǔhàobìng'') rather than FMD in reports because of the sensitivity of the FMD issue. In March 2010, ''Southern Rural News'' (''Nanfang Nongcunbao''), in an article "Breaking the Hoof and Mouth Disease Taboo", noted that FMD has long been covered up in China by referring to it that way. FMD is also called canker (口疮, literally "mouth ulcers" ''kǒuchuāng'') or hoof jaundice (蹄癀 ''tíhuáng'') in China, so information on FMD in China can be found online using those words as search terms. One can find online many provincial orders and regulations on FMD control antedating China's acknowledgment that the disease existed in China, for example Guangxi Zhuang Autonomous Region 1991 regulation on preventing the spread of Disease No.5.


United Kingdom (2007)

An infection of FMD in the United Kingdom was confirmed by the
Department for Environment, Food and Rural Affairs The Department for Environment, Food and Rural Affairs (Defra) is a Departments of the Government of the United Kingdom, ministerial department of the government of the United Kingdom. It is responsible for environmental quality, environmenta ...
, on 3 August 2007, on farmland located in
Normandy Normandy (; or ) is a geographical and cultural region in northwestern Europe, roughly coextensive with the historical Duchy of Normandy. Normandy comprises Normandy (administrative region), mainland Normandy (a part of France) and insular N ...
, Surrey. All livestock in the vicinity were culled on 4 August. A nationwide ban on the movement of cattle and pigs was imposed, with a 3-km (1.9-mi) protection zone placed around the outbreak sites and the nearby virus research and vaccine production establishments, together with a 10-km (6.2-mi) increased surveillance zone. On 4 August, the strain of the virus was identified as a "01 BFS67-like" virus, one linked to vaccines and not normally found in animals, and isolated in the 1967 outbreak. The same strain was used at the nearby Institute for Animal Health and Merial Animal Health Ltd at
Pirbright Pirbright () is a village in Surrey, England. Pirbright is in the Guildford (borough), borough of Guildford and has a civil parish council covering the traditional boundaries of the area. Pirbright contains one buffered sub-locality, Stanford ...
, away, which is an American/French-owned BSL-4 vaccine manufacturing facility, and was identified as the likely source of infection. On 12 September, a new outbreak of the disease was confirmed in
Egham Egham ( ) is a town in the Borough of Runnymede in Surrey, England, approximately west of central London. First settled in the Bronze Age, the town was under the control of Chertsey Abbey for much of the Middle Ages. In 1215, Magna Carta was ...
,
Surrey Surrey () is a Ceremonial counties of England, ceremonial county in South East England. It is bordered by Greater London to the northeast, Kent to the east, East Sussex, East and West Sussex to the south, and Hampshire and Berkshire to the wes ...
, from the original outbreak, with a second case being confirmed on a nearby farm on 14 September. These outbreaks caused a cull of all at-risk animals in the area surrounding Egham, including two farms near the famous four-star hotel Great Fosters. These outbreaks also caused the closure of
Windsor Great Park Windsor Great Park is a Royal Park of to the south of the town of Windsor, Berkshire, Windsor on the border of Berkshire and Surrey in England. It is adjacent to the private Home Park, Windsor, Home Park, which is nearer the castle. The park ...
due to the park containing deer; the park remained closed for three months. On 19 September 2007, a suspected case of FMD was found in
Solihull Solihull ( ) is a market town and the administrative centre of the Metropolitan Borough of Solihull, in the West Midlands (county), West Midlands, England. Solihull is situated on the River Blythe in the Arden, Warwickshire, Forest of Arden ar ...
, where a temporary control zone was set up by Defra.


Japan and Korea (2010–2011)

In April 2010, a report of three incursions of FMD in
Japan Japan is an island country in East Asia. Located in the Pacific Ocean off the northeast coast of the Asia, Asian mainland, it is bordered on the west by the Sea of Japan and extends from the Sea of Okhotsk in the north to the East China Sea ...
and
South Korea South Korea, officially the Republic of Korea (ROK), is a country in East Asia. It constitutes the southern half of the Korea, Korean Peninsula and borders North Korea along the Korean Demilitarized Zone, with the Yellow Sea to the west and t ...
led the United Nations Food and Agriculture Organization (FAO) to issue a call for increased global surveillance. Japan veterinary authorities confirmed an outbreak of type O FMD virus, currently more common in Asian countries where FMD is endemic. South Korea was hit by the rarer type A FMD in January, and then the type O infection in April. The most serious case of foot-and-mouth outbreak in South Korea's history started in November 2010 in pig farms in
Andong Andong () is a Administrative divisions of South Korea, city in South Korea, and the capital of North Gyeongsang Province. It is the largest city in the northern part of the province with a population of 167,821 as of October 2010. The Nakdong Ri ...
city of
Gyeongsangbuk-do North Gyeongsang Province (, ) is a province in eastern South Korea, and with an area of , it is the largest province in the Korean peninsula. The province was formed in 1896 from the northern half of the former Gyeongsang province, and remaine ...
, and has since spread in the country rapidly. More than 100 cases of the disease have been confirmed in the country so far, and in January 2011,
South Korea South Korea, officially the Republic of Korea (ROK), is a country in East Asia. It constitutes the southern half of the Korea, Korean Peninsula and borders North Korea along the Korean Demilitarized Zone, with the Yellow Sea to the west and t ...
n officials started a mass cull of approximately 12%, or around three million in total, of the entire domestic pig population, and 107,000 of three million cattle of the country to halt the outbreak. According to the report based on complete 1D gene sequences, Korean serotype A virus was linked with those from Laos. Korean serotype O viruses were divided into three clades and were closely related to isolates from Japan, Thailand, the UK, France, Ireland, South Africa, and Singapore, as well as Laos. On 10 February 2011,
North Korea North Korea, officially the Democratic People's Republic of Korea (DPRK), is a country in East Asia. It constitutes the northern half of the Korea, Korean Peninsula and borders China and Russia to the north at the Yalu River, Yalu (Amnok) an ...
reported an outbreak affecting pigs in the region around
Pyongyang Pyongyang () is the Capital city, capital and largest city of North Korea, where it is sometimes labeled as the "Capital of the Revolution" (). Pyongyang is located on the Taedong River about upstream from its mouth on the Yellow Sea. Accordi ...
, by then ongoing since at least December 2010. Efforts to control the outbreak were hampered by illicit sales of infected meat.


Indonesia (2022)

After being eradicated there in 1986, FMD was again detected in
Indonesia Indonesia, officially the Republic of Indonesia, is a country in Southeast Asia and Oceania, between the Indian Ocean, Indian and Pacific Ocean, Pacific oceans. Comprising over List of islands of Indonesia, 17,000 islands, including Sumatra, ...
in May 2022. The
Australian government The Australian Government, also known as the Commonwealth Government or simply as the federal government, is the national executive government of Australia, a federal parliamentary constitutional monarchy. The executive consists of the pr ...
has offered its assistance but remains unconcerned, considering the risk to the country's biosecurity to be low. The
Department of Agriculture An agriculture ministry (also called an agriculture department, agriculture board, agriculture council, or agriculture agency, or ministry of rural development) is a ministry charged with agriculture. The ministry is often headed by a minister f ...
(DAWE) is the responsible body and has been monitoring the situation. DAWE has determined there is only a low risk and has stockpiled
vaccines A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. The safety and effectiveness of vaccines has been widely studied and verified. A vaccine typically contains an ag ...
since 2004 anyhow. In response to the Indonesian outbreak, Australian authorities began checking parcels and baggage from Indonesia and China. Disinfectant floormats were also installed at Australian airports to clean footwear. The Albanese Government rejected calls by opposition parties to close the border to travel from Indonesia. In addition, New Zealand authorities have banned travellers from Indonesia from bringing meat products, have screened baggage from Indonesia, and installed floor mats. New Zealand Prime Minister
Jacinda Ardern Dame Jacinda Kate Laurell Ardern ( ; born 26 July 1980) is a New Zealand politician and activist who was the 40th prime minister of New Zealand and Leader of the New Zealand Labour Party, leader of the Labour Party from 2017 to 2023. She was ...
and Biosecurity Minister Damien O'Connor have expressed concern about the impact of foot and mouth disease on New Zealand's substantial cattle, sheep and pig populations as well as wildlife.


Germany (2025)

In January 2025, an outbreak of foot-and-mouth disease was reported in a herd of water buffalo near Berlin. A 3 kilometre exclusion zone and a 10 kilometre monitoring zone were imposed, and after four days no further cases had been detected within 1 kilometre of the original case.


Hungary and Slovakia (2025)

On March 8th, 2025, a confirmed case of foot-and-mouth disease was reported at a cattle farm in
Kisbajcs Kisbajcs is a village in Győr-Moson-Sopron county, Hungary Hungary is a landlocked country in Central Europe. Spanning much of the Pannonian Basin, Carpathian Basin, it is bordered by Slovakia to the north, Ukraine to the northeast, Roma ...
, located in the northwestern corner of
Hungary Hungary is a landlocked country in Central Europe. Spanning much of the Pannonian Basin, Carpathian Basin, it is bordered by Slovakia to the north, Ukraine to the northeast, Romania to the east and southeast, Serbia to the south, Croatia and ...
, the first such case in 50 years. Immediate counter-measures were made to mitigate the spread of the disease, including the liquidation of all 1400 animals in the affected herd and the burial of their carcasses. The government of the United Kingdom subsequently banned all imports of cattle, sheep, pigs and deer, as well as banning travellers from bringing meat and dairy products with them, from both Hungary and neighbouring
Slovakia Slovakia, officially the Slovak Republic, is a landlocked country in Central Europe. It is bordered by Poland to the north, Ukraine to the east, Hungary to the south, Austria to the west, and the Czech Republic to the northwest. Slovakia's m ...
due to the farm's proximity to the country's border. As of March 10th, 2025, the eradication of the disease was still in progress. On March 21st, 2025, the foot-and-mouth disease was confirmed to cross the Hungarian-Slovak border with three cattle farms in villages Medveďov, Ňárad and Baka in Dunajská Streda district having the cases of the disease. The Fourth Slovak farm with infected cattle confirmed was in village Lúč na Ostrove on March 25, with another source of the disease confirmed in Hungarian village Levél on March 26. A Fifth infected farm in Slovakia was confirmed on March 30 in Plavecký Štvrtok. Both countries started with strict border controls, including stopping of traffic on several border crossings. All Slovak zoological gardens were closed temporarily.


History

The cause of FMD was first shown to be viral in 1897 by Friedrich Loeffler. He passed the
blood Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood is com ...
of an infected animal through a
Chamberland filter A Chamberland filter, also known as a Pasteur–Chamberland filter, is a porcelain water filter invented by Charles Chamberland in 1884. It was developed after Henry Doulton's ceramic water filter of 1827. It is similar to the Berkefeld fil ...
and found the collected fluid could still cause the disease in healthy animals. FMD occurs throughout much of the world, and while some countries have been free of FMD for some time, its wide host range and rapid spread represent cause for international concern. After
World War II World War II or the Second World War (1 September 1939 – 2 September 1945) was a World war, global conflict between two coalitions: the Allies of World War II, Allies and the Axis powers. World War II by country, Nearly all of the wo ...
, the disease was widely distributed throughout the world. In 1996, endemic areas included
Asia Asia ( , ) is the largest continent in the world by both land area and population. It covers an area of more than 44 million square kilometres, about 30% of Earth's total land area and 8% of Earth's total surface area. The continent, which ...
,
Africa Africa is the world's second-largest and second-most populous continent after Asia. At about 30.3 million km2 (11.7 million square miles) including adjacent islands, it covers 20% of Earth's land area and 6% of its total surfac ...
, and parts of
South America South America is a continent entirely in the Western Hemisphere and mostly in the Southern Hemisphere, with a considerably smaller portion in the Northern Hemisphere. It can also be described as the southern Subregion#Americas, subregion o ...
; as of August 2007,
Chile Chile, officially the Republic of Chile, is a country in western South America. It is the southernmost country in the world and the closest to Antarctica, stretching along a narrow strip of land between the Andes, Andes Mountains and the Paci ...
is disease-free, and
Uruguay Uruguay, officially the Oriental Republic of Uruguay, is a country in South America. It shares borders with Argentina to its west and southwest and Brazil to its north and northeast, while bordering the Río de la Plata to the south and the A ...
and
Argentina Argentina, officially the Argentine Republic, is a country in the southern half of South America. It covers an area of , making it the List of South American countries by area, second-largest country in South America after Brazil, the fourt ...
have not had an outbreak since 2001. In May 2014, the
FAO The Food and Agriculture Organization of the United Nations; . (FAO) is a List of specialized agencies of the United Nations, specialized agency of the United Nations that leads international efforts to defeat hunger and improve nutrition ...
informed that
Bolivia Bolivia, officially the Plurinational State of Bolivia, is a landlocked country located in central South America. The country features diverse geography, including vast Amazonian plains, tropical lowlands, mountains, the Gran Chaco Province, w ...
,
Colombia Colombia, officially the Republic of Colombia, is a country primarily located in South America with Insular region of Colombia, insular regions in North America. The Colombian mainland is bordered by the Caribbean Sea to the north, Venezuel ...
,
Ecuador Ecuador, officially the Republic of Ecuador, is a country in northwestern South America, bordered by Colombia on the north, Peru on the east and south, and the Pacific Ocean on the west. It also includes the Galápagos Province which contain ...
and
Peru Peru, officially the Republic of Peru, is a country in western South America. It is bordered in the north by Ecuador and Colombia, in the east by Brazil, in the southeast by Bolivia, in the south by Chile, and in the south and west by the Pac ...
were "just one step away" from eradication; North America and Australia have been free of FMD for many years. New Zealand has never had a case of foot-and-mouth disease. Most European countries have been recognized as disease-free, and countries belonging to the European Union have stopped FMD vaccination. However, in 2001, 2001 UK foot-and-mouth crisis, a serious outbreak of FMD in Great Britain, Britain resulted in the slaughter of many animals, the postponing of the 2001 United Kingdom general election, general election for a month, and the cancellation of many sporting events and leisure activities, such as the Isle of Man TT. Due to strict government policies on sale of livestock, disinfection of all persons leaving and entering farms, and the cancellation of large events likely to be attended by farmers, a potentially economically disastrous
epizootic In epizoology, an epizootic (or epizoötic, from Greek: ''epi-'' "upon" + ''zoon'' "animal") is a disease event in a nonhuman animal population analogous to an epidemic in humans. An epizootic disease (or ) may occur in a specific locale (an ...
was avoided in Republic of Ireland, Ireland, with just one case recorded in Proleek, County Louth. As one result, the Animal Health Act 2002 was designed by Parliament to provide the regulators with more powers to deal with FMD. In August 2007, FMD was found at two farms in
Surrey Surrey () is a Ceremonial counties of England, ceremonial county in South East England. It is bordered by Greater London to the northeast, Kent to the east, East Sussex, East and West Sussex to the south, and Hampshire and Berkshire to the wes ...
, England. All livestock were culled and a quarantine erected over the area. Two other suspected outbreaks have occurred since, although these seem now not to be related to FMD. The only reported case in 2010 was a false alarm from GIS Alex Baker, as proven false by the Florida Farm and Agricultural Department, and quarantine/slaughter of cattle and pigs was confirmed from Miyazaki Prefecture in Japan in June after three cows tested positive. Some 270,000 cattle have been ordered slaughtered following the disease's outbreak. In 2022, the disease was once again seen in cattle in
Indonesia Indonesia, officially the Republic of Indonesia, is a country in Southeast Asia and Oceania, between the Indian Ocean, Indian and Pacific Ocean, Pacific oceans. Comprising over List of islands of Indonesia, 17,000 islands, including Sumatra, ...
. Other countries are worried that it might spread to their countries soon. In Early 2025, the disease was confirmed to have an outbreak in Germany, and later a series of confirmed cases in
Hungary Hungary is a landlocked country in Central Europe. Spanning much of the Pannonian Basin, Carpathian Basin, it is bordered by Slovakia to the north, Ukraine to the northeast, Romania to the east and southeast, Serbia to the south, Croatia and ...
and
Slovakia Slovakia, officially the Slovak Republic, is a landlocked country in Central Europe. It is bordered by Poland to the north, Ukraine to the east, Hungary to the south, Austria to the west, and the Czech Republic to the northwest. Slovakia's m ...
were found in the month of March.


Ethical considerations

Great Britain's response to the 2001 outbreak of foot and mouth disease was a controversial policy of culling all animals within 3 km of an infected farm within 48 hours, leading to the slaughter of over 4 million animals. This was stated to be "a response to a desperate situation, not a pre-meditated response to a known, assessed risk". FMD is usually nonfatal to adult animals. Pigs are capable of airborne transmission of the virus in one extreme case 250 km across the English Channel, although not usually more than 10 km. There are no known cases of cattle or sheep spreading the virus beyond 3 km. The 2007 outbreak was caught much earlier, and was able to be contained after culling only 1,578 animals. For the farmer, culling animals often results in financial devastation with no ability to honor existing contractual arrangements, thus facing the prospective loss of farm, equipment, and future earning potential. Farmers, especially in more traditional systems, may also have emotional attachments to some of the animals. On the ethical side, one must also consider that FMD is a painful disease for the affected animals. The vesicles and blisters are painful in themselves, and restrict both eating and movement. Through ruptured blisters, the animal is also at risk from secondary bacterial infections. Production loss and vaccination in areas where the disease is endemic costs and estimated US$6.5 billion to 21 billion yearly, and controlling outbreaks in countries normally free of it costs and additional >US$1.5 billion per year. This cost is disproportionately borne by some of the poorest countries in the world. Controlling the virus with vaccines is difficult because there are multiple serotypes of the virus which require distinct vaccines. When an outbreak occurs, the virus must be analyzed before the correct vaccine can be identified. Research is ongoing to improve vaccination technology.


See also

* Animal virology * Hand, foot and mouth disease (HFMD) * Swine vesicular disease (SVD) * Blain (animal disease), Blain, an archaic disease of uncertain etiology


References


External links


FMD Myocarditis in Pigs
*

12-part comprehensive overview from the Center for Infectious Disease Research and Policy
FMD portal


*
Current status of Foot and Mouth Disease worldwide
at OIE. WAHID Interface—OIE World Animal Health Information Database
Disease card

The European Commission for the Control of Foot-and-Mouth Disease (EuFMD)

Species Profile – Foot and Mouth Disease
National Invasive Species Information Center, United States National Agricultural Library. {{DEFAULTSORT:Foot-And-Mouth Disease Foot-and-mouth outbreaks, * Animal viral diseases Bovine diseases Sheep and goat diseases Infectious diseases with eradication efforts Health disasters Food safety in the European Union History of agriculture in the United Kingdom Agricultural health and safety Food law Biological anti-agriculture weapons