eye color

Eye color is a polygenic phenotypic character determined by two distinct factors: the pigmentation of the

eye

's iris and the frequency-dependence of the

scattering

of light by the

turbid

medium in the stroma of the iris.

In humans, the pigmentation of the iris varies from light brown to black, depending on the concentration of

melanin

in the iris pigment epithelium (located on the back of the iris), the melanin content within the iris stroma (located at the front of the iris), and the cellular density of the stroma. The appearance of blue and green, as well as hazel eyes, results from the

Tyndall scattering

of light in the stroma, a phenomenon similar to that which accounts for the blueness of the sky called

Rayleigh scattering

. Neither blue nor green pigments are ever present in the human iris or ocular fluid. Eye color is thus an instance of

structural color

and varies depending on the lighting conditions, especially for lighter-colored eyes.

The brightly colored eyes of many bird species result from the presence of other pigments, such as pteridines,

purine

s, and carotenoids. Humans and other animals have many phenotypic variations in eye color.Morris, PJ
"Phenotypes and Genotypes for human eye colors."
Athro Limited website. Retrieved 10 May 2006.

The genetics and inheritance of eye color in humans is complicated. So far, as many as 15 genes have been associated with eye color inheritance. Some of the eye-color genes include ''OCA2'' and ''HERC2''. The earlier belief that blue eye color is a simple recessive trait has been shown to be incorrect. The genetics of eye color are so complex that almost any parent-child combination of eye colors can occur. However, OCA2 gene polymorphism, close to proximal 5' regulatory region, explains most human eye-color variation.

Genetic determination

Eye color is an inherited trait influenced by more than one

gene

. These genes are sought using associations to small changes in the genes themselves and in neighboring genes. These changes are known as single-nucleotide polymorphisms or SNPs. The actual number of genes that contribute to eye color is currently unknown, but there are a few likely candidates. A study in

Rotterdam

(2009) found that it was possible to predict eye color with more than 90% accuracy for brown and blue using just six SNPs. There is evidence that as many as 16 different genes could be responsible for eye color in humans; however, the main two genes associated with eye color variation are ''OCA2'' and ''HERC2'', and both are localized in Chromosome 15.

The gene ''OCA2'' (), when in a variant form, causes the pink eye color and hypopigmentation common in human albinism. (The name of the gene is derived from the disorder it causes, oculocutaneous albinism type II.) Different SNPs within ''OCA2'' are strongly associated with blue and green eyes as well as variations in freckling, mole counts,

hair

and skin tone. The polymorphisms may be in an ''OCA2'' regulatory sequence, where they may influence the expression of the gene product, which in turn affects pigmentation. A specific mutation within the ''HERC2'' gene, a gene that regulates ''OCA2'' expression, is partly responsible for blue eyes. Other genes implicated in eye color variation are SLC24A4 and TYR. A 2010 study on eye color variation into hue and saturation values using high-resolution digital full-eye photographs found three new loci for a total of ten genes, and now about 50% of eye colour variation can be explained.

Blue eyes with a brown spot, green eyes, and gray eyes are caused by an entirely different part of the genome.

Ancient DNA and eye color in Europe

People of European descent show the greatest variety in eye color of any population worldwide. Recent advances in

ancient DNA

technology have revealed some of the history of eye color in Europe. All European

Mesolithic

hunter-gatherer remains so far investigated have shown genetic markers for light-colored eyes, in the case of western and central European hunter-gatherers combined with dark skin color. The later additions to the European gene pool, the Early Neolithic farmers from Anatolia and the

Yamnaya

Copper Age/Bronze Age pastoralists (possibly the Proto-Indo-European population) from the area north of the

Black Sea

appear to have had much higher incidences of dark eye color alleles, and alleles giving rise to lighter skin, than the original European population.

Classification of color

Iris color can provide a large amount of information about a person, and a classification of colors may be useful in documenting pathological changes or determining how a person may respond to ocular pharmaceuticals. Classification systems have ranged from a basic light or dark description to detailed gradings employing photographic standards for comparison. Others have attempted to set objective standards of color comparison.Fan S, Dyer CR, Hubbard L
Quantification and Correction of Iris Color."
Technical report 1495, University of Wisconsin–Madison, Dec 2003.

Normal eye colors range from the darkest shades of brown to the lightest tints of blue. To meet the need for standardized classification, at once simple yet detailed enough for research purposes, Seddon et al. developed a graded system based on the predominant iris color and the amount of brown or yellow pigment present. There are three pigment colors that determine, depending on their proportion, the outward appearance of the iris, along with

structural color

. Green irises, for example, have some yellow and the blue structural color. Brown irises contain more or less melanin. Some eyes have a dark ring around the iris, called a limbal ring.

Eye color in non-human animals is regulated differently. For example, instead of blue as in humans, autosomal recessive eye color in the skink species ''

Corucia zebrata

'' is black, and the autosomal dominant color is yellow-green.

As the

perception of color

depends on viewing conditions (e.g., the amount and kind of illumination, as well as the hue of the surrounding environment), so does the perception of eye color.

Changes in eye color

Most newborn babies who have European ancestry have light-colored eyes. As the child develops, melanocytes (cells found within the iris of human eyes, as well as skin and hair follicles) slowly begin to produce

melanin

. Because melanocyte cells continually produce pigment, in theory eye color can be changed. Adult eye color is usually established between 3 and 6 months of age, though this can be later. Observing the iris of an infant from the side using only transmitted light with no reflection from the back of the iris, it is possible to detect the presence or absence of low levels of melanin. An iris that appears blue under this method of observation is more likely to remain blue as the infant ages. An iris that appears golden contains some melanin even at this early age and is likely to turn from blue to green or brown as the infant ages.

Changes (lightening or darkening) of eye colors during early childhood, puberty, pregnancy, and sometimes after serious trauma (like

heterochromia

) do represent cause for a plausible argument stating that some eyes can or do change, based on chemical reactions and hormonal changes within the body.

Studies on Caucasian twins, both fraternal and identical, have shown that eye color over time can be subject to change, and major demelanization of the iris may also be genetically determined. Most eye-color changes have been observed or reported in the Caucasian population with hazel and amber eyes.
Under the same environmental conditions, there may be disagreement over the color of an object between two different people, and the factor that causes this disagreement is pigments called Melanin, which are the main factors in determining eye color. The higher the amount of these pigments in the Iris and the denser their texture, the darker the color of a person's eyes; The same melanin concentration also depends on many factors such as hereditary, environmental, and other factors. The most important role of eye melanins is to protect the eyes from the sun's harmful rays. People with bright eyes (honey, blue, or green) have fewer sunscreens than other people. Therefore, they should protect their eyes from the sun more than other people.

The human eye consists of two types of light and color receptors in the Retina. Cylindrical cells are the photoreceptors of the eye that have a black and white vision and, depending on the amount of light received from the environment, determine the amount of darkness and brightness of objects. The number of cylindrical cells is more than the number of color receptors and reaches about 120 million; Cone cells, which are smaller in number than light receptors, have color vision and are divided into three distinct categories, each of which recognizes one of the colors blue, red, and green, allowing the individual to distinguish colors.

When a person is exposed to sunlight, the rays of sunlight hit a part of the back of the eye called the Yellow spot. The cylindrical cells receive these rays, make a neural message from them, and send them to the occipital region of the brain, where they are examined and answered if necessary. At this time, a large amount of ultraviolet light is received by the eye and destroys parts of the light receptors. Because people with bright eyes have less melanin in their eyes than people with dark eyes, the lack of this protective factor means that the light receptors in their eyes are more damaged and destroyed than in other people. This difference in the number of light receptors in the eyes of different people causes a difference in the amount of light they receive from the environment; For this reason, people with bright eyes see colors a little darker than others; But this amount is so small that it is not very visible in everyday life and only appears as a slight difference of opinion between people with different eye colors.

Eye color chart (Martin scale)

Carleton Coon created a chart by the original Martin scale. The numbering is reversed on the scale below in the (later) Martin–Schultz scale, which is (still) used in physical anthropology.

Light and light-mixed eyes (16–12 in Martin scale)

Pure light (16–15 in Martin scale)
* 16: pure light blue
* 15: gray

Light-mixed (14–12 in Martin scale)
* 14: Very light-mixed (blue with gray or green or green with gray)
* 13-12: Light-mixed (light or very light-mixed with small admixture of brown)

Mixed eyes (11–7 in Martin scale)
* Mixture of light eyes (blue, gray or green) with brown when light and brown appearance is at the same level

Dark and dark-mixed eyes (6–1 in Martin scale)
* Dark-mixed: 6–5 in Martin scale. Brown with small admixture of light
* Dark: 4–1 in Martin scale. Brown (light brown and dark brown) and very dark brown (almost black)

Amber

Amber eyes are of a solid color and have a strong yellowish/golden and russet/coppery tint. This may be due to the deposition of the yellow pigment called lipochrome in the iris (which is also found in green eyes). Amber eyes should not be confused with hazel eyes; although hazel eyes may contain specks of amber or gold, they usually tend to comprise many other colors, including green, brown and orange. Also, hazel eyes may appear to shift in color and consist of flecks and ripples, while amber eyes are of a solid gold hue. Even though amber is considered to be like gold, some people have russet or copper colored amber eyes that many people mistake for hazel, though hazel tends to be duller and contains green with red/gold flecks, as mentioned above. Amber eyes may also contain amounts of very light gold-ish gray.

The eyes of some pigeons contain yellow fluorescing pigments known as pteridines. The bright yellow eyes of the great horned owl are thought to be due to the presence of the pteridine pigment

xanthopterin

within certain chromatophores (called xanthophores) located in the iris stroma. In humans, yellowish specks or patches are thought to be due to the pigment lipofuscin, also known as lipochrome. Many animals such as canines, domestic cats, owls, eagles, pigeons and fish have amber eyes as a common color, whereas in humans this color occurs less frequently. With a world population share of 5%, amber eyes are extremely rare anywhere in the world. It is possible to find people with that eye color in the

Balkan region

, as well as in

Hungary

, in Southern France,

Italy

, and to a lesser degree in the

Iberian Peninsula

, Southern Cone and

Middle East

. In

Brazil

, it can be found particularly in the Southern Region, as well as in São Paulo,

Minas Gerais

and other places that received strong European immigration.

Blue

There is no blue pigmentation either in the iris or in the ocular fluid. Dissection reveals that the iris pigment epithelium is brownish black due to the presence of

melanin

. Unlike brown eyes, blue eyes have low concentrations of melanin in the stroma of the iris, which lies in front of the dark epithelium. Longer wavelengths of light tend to be absorbed by the dark underlying epithelium, while shorter wavelengths are reflected and undergo

Rayleigh scattering

in the

turbid

medium of the stroma. This is the same frequency-dependence of scattering that accounts for the blue appearance of the sky. The result is a "

Tyndall

blue"

structural color

that varies with external lighting conditions.

In humans, the inheritance pattern followed by blue eyes is considered similar to that of a recessive trait (in general, eye color inheritance is considered a polygenic trait, meaning that it is controlled by the interactions of several genes, not just one). In 2008, new research tracked down a single genetic mutation that leads to blue eyes. "Originally, we all had brown eyes," said Eiberg. Eiberg and colleagues suggested in a study published in ''Human Genetics'' that a mutation in the 86th

intron

of the ''HERC2'' gene, which is hypothesized to interact with the ''OCA2'' gene promoter, reduced expression of ''OCA2'' with subsequent reduction in melanin production. The authors suggest that the mutation may have arisen in the northwestern part of the

Black Sea

region, and add that it is "difficult to calculate the age of the mutation."

Blue eyes are common in northern and eastern Europe, particularly around the

Baltic Sea

. Blue eyes are also found in southern Europe,

Central Asia

,

South Asia

,

North Africa

and West Asia.

File:Bimbam.jpg, A

Birman kitten

with distinctive

sapphire

blue eyes
File:Karasu2a.JPG, Jungle crow
File:FrankieakaLogan.jpg, The first blue-eyed

koala

known to be born in captivity

The same DNA sequence in the region of the OCA2 gene among blue-eyed people suggests they may have a single common ancestor.

, the earliest remains of

Homo sapiens

with genes for both light-pigmentation and blue-eyes were found in 7,700 years old Mesolithic hunter-gatherers from Motala,

Sweden

.

Approximately 8% to 10% of the global population have blue eyes. A 2002 study found that the prevalence of blue eye color among the white population in the United States to be 33.8% for those born from 1936 through 1951, compared with 57.4% for those born from 1899 through 1905. , one out of every six Americans, or 16.6% of the total US population, has blue eyes, including 22.3% of whites. Blue eyes are continuing to become less common among American children. 56% of Slovenes have blue/green eyes.

Blue eyes are rare in mammals; one example is the recently discovered marsupial, the blue-eyed spotted cuscus (''Spilocuscus wilsoni''). The trait is hitherto known only from a single

primate

other than humans – Sclater's lemur (''Eulemur flavifrons'') of Madagascar. While some

cat

s and

dog

s have blue eyes, this is usually due to another mutation that is associated with deafness. But in cats alone, there are four identified gene mutations that produce blue eyes, some of which are associated with congenital neurological disorders. The mutation found in the

Siamese cat

s is associated with

strabismus

(crossed eyes). The mutation found in blue-eyed solid white cats (where the coat color is caused by the gene for "epistatic white") is linked with deafness. However, there are phenotypically identical, but genotypically different, blue-eyed white cats (where the coat color is caused by the gene for white spotting) where the coat color is not strongly associated with deafness. In the blue-eyed

Ojos Azules

breed, there may be other neurological defects. Blue-eyed non-white cats of unknown genotype also occur at random in the cat population.

Brown

In humans, brown eyes result from a relatively high concentration of melanin in the stroma of the iris, which causes light of both shorter and longer wavelengths to be absorbed.

Dark brown eyes are dominant in humans and in many parts of the world, it is nearly the only iris color present. Brown eyes are common in

Europe

,

East Asia

,

Southeast Asia

,

Central Asia

,

South Asia

, West Asia,

Oceania

,

Africa

and the

Americas

. Brown is by far the most common eye color, with approximately 79% of people in the world having it.

Light or medium-pigmented brown eyes can also be commonly found in South Europe, among the

Americas

, and parts of Central

Asia

, West Asia and

South Asia

.

Gray

Like blue eyes, gray eyes have a dark epithelium at the back of the iris and a relatively clear stroma at the front. One possible explanation for the difference in the appearance of gray and blue eyes is that gray eyes have larger deposits of

collagen

in the stroma, so that the light that is reflected from the epithelium undergoes

Mie scattering

(which is not strongly frequency-dependent) rather than Rayleigh scattering (in which shorter wavelengths of light are scattered more). This would be analogous to the change in the color of the sky, from the blue given by the Rayleigh scattering of sunlight by small gas molecules when the sky is clear, to the gray caused by Mie scattering of large water droplets when the sky is cloudy. Alternatively, it has been suggested that gray and blue eyes might differ in the concentration of melanin at the front of the stroma.

Gray eyes can also be found among the

Algeria

n Shawia people of the Aurès Mountains in Northwest Africa, in the

Middle East

/West Asia,

Central Asia

, and

South Asia

. The Greek goddess Athene appears with grey eyes (γλαυκῶπις). Under magnification, gray eyes exhibit small amounts of yellow and brown color in the iris.

Gray is the second-rarest natural eye color after green, with 3% of the world's population having it.

Green

As with blue eyes, the color of green eyes does not result simply from the pigmentation of the iris. The green color is caused by the combination of: 1) an amber or light brown pigmentation in the stroma of the iris (which has a low or moderate concentration of melanin) with: 2) a blue shade created by the Rayleigh scattering of reflected light. Green eyes contain the yellowish pigment lipochrome.

Green eyes probably result from the interaction of multiple variants within the ''OCA2'' and other genes. They were present in south Siberia during the Bronze Age.

They are most common in Northern Europe, Northern, Western Europe, Western and Central Europe. In Scotland and Ireland, 86% of people have either blue or green eyes. In Iceland, 89% of women and 87% of men have either blue or green eye color. Among European Americans, green eyes are most common among those of recent Celts (modern), Celtic and Germanic peoples, Germanic ancestry, about 16%. 40.8% of Italians from Verona, 22.5% of Spaniards from Alicante and 15.4% of Greeks from Athens have green, grey, and blue eyes. Globally, however, green is considered the rarest natural eye color; only 2% of the world's population have it.

Hazel

Hazel eyes are due to a combination of

Rayleigh scattering

and a moderate amount of melanin in the iris' anterior border layer. Hazel eyes often appear to shift in color from a brown to a green. Although hazel mostly consists of brown and green, the dominant color in the eye can either be brown/gold or green. This is how many people mistake hazel eyes to be amber and vice versa. This can sometimes produce a multicolored iris, i.e., an eye that is light brown/amber near the pupil and charcoal or dark green on the outer part of the iris (or vice versa) when observed in sunlight.

Definitions of the eye color ''hazel'' vary: it is sometimes considered to be synonymous with light brown or gold, as in the color of a hazelnut shell.

Around 18% of the US population and 5% of the world population have hazel eyes.

Special cases

Red and violet

The eyes of people with severe forms of albinism may appear red under certain lighting conditions owing to the extremely low quantities of

melanin

,NOAH – What is Albinism?
. Albinism.org. Retrieved on 23 December 2011. allowing the blood vessels to show through. In addition, flash photography can sometimes cause a "red-eye effect", in which the very bright light from a flash reflects off the retina, which is abundantly vascular, causing the pupil to appear red in the photograph. Although the deep blue eyes of some people such as Elizabeth Taylor can appear violet at certain times, "true" violet-colored eyes occur only due to albinism. Eyes that appear red or violet under certain conditions due to albinism are less than 1 percent of the world's population.

Two different colors

As a result of heterochromia iridum, it is also possible to have two different eye colors. This occurs in humans and certain breeds of domesticated animals and affects less than 1 percent of the world's population.

Spectrum of eye color

File:eye55.jpg
File:Blue-green eye closeup.JPG
File:Eye Central Heterochromia crop and lighter.jpg
File:Humaniris.jpg
File:Hazel Eyes, Caucasian Male, Age 23.jpg
File:Human Iris JD052007.jpg
File:Greeneye.jpg
File:Hazel green eye close up.jpg
File:Hazel eye1.png
File:Green Eye.jpg
File:Green light mixed type B.JPG
File:Eye big.JPG
File:Amber Brown Green.jpg
File:amber-eyes.jpg
File:MyStrangeIris.JPG
File:Indianeye.png
File:Lens5.jpg

Medical implications

Those with lighter iris color have been found to have a higher prevalence of macular degeneration, age-related macular degeneration (ARMD) than those with darker iris color; lighter eye color is also associated with an increased risk of ARMD progression. A gray iris may indicate the presence of a uveitis, and an increased risk of uveal melanoma has been found in those with blue, green or gray eyes. However, a study in 2000 suggests that people with dark brown eyes are at increased risk of developing cataracts and therefore should protect their eyes from direct exposure to sunlight.

Wilson's disease

Wilson's disease involves a mutation of the gene coding for the enzyme Wilson disease protein, ATPase 7B, which prevents copper within the liver from entering the Golgi apparatus in cells. Instead, the copper accumulates in the liver and in other tissues, including the iris of the eye. This results in the formation of Kayser–Fleischer rings, which are dark rings that encircle the periphery of the iris.

Coloration of the sclera

Eye color outside of the iris may also be symptomatic of disease. Yellowing of the sclera (the "whites of the eyes") is associated with jaundice, and may be symptomatic of liver diseases such as cirrhosis or hepatitis. A blue coloration of the sclera may also be symptomatic of disease.

Aniridia

Aniridia is a congenital condition characterized by an extremely underdeveloped iris, which appears absent on superficial examination.

Ocular albinism and eye color

Normally, there is a thick layer of melanin on the back of the iris. Even people with the lightest blue eyes, with no melanin on the front of the iris at all, have dark brown coloration on the back of it, to prevent light from scattering around inside the eye. In those with milder forms of albinism, the color of the iris is typically blue but can vary from blue to brown. In severe forms of albinism, there is no pigment on the back of the iris, and light from inside the eye can pass through the iris to the front. In these cases, the only color seen is the red from the hemoglobin of the blood in the capillaries of the iris. Such albinos have pink eyes, as do albino rabbits, mice, or any other animal with a total lack of melanin. Transillumination defects can almost always be observed during an eye examination due to lack of iridial pigmentation. The ocular albino also lacks normal amounts of melanin in the retina as well, which allows more light than normal to reflect off the retina and out of the eye. Because of this, the Pupillary light reflex, pupillary reflex is much more pronounced in albino individuals, and this can emphasize the red eye effect in photographs.

Heterochromia

Heterochromia (''heterochromia iridum'' or ''heterochromia iridis'') is an eye condition in which one iris is a different color from the other (complete heterochromia), or where a part of one iris is a different color from the remainder (partial heterochromia or sectoral heterochromia). It is a result of the relative excess or lack of pigment within an iris or part of an iris, which may be Biological inheritance, inherited or acquired by disease or injury. This uncommon condition usually results due to uneven

melanin

content. A number of causes are responsible, including genetic, such as Chimera (genetics), chimerism, Horner's syndrome and Waardenburg syndrome.

A Chimera (genetics), chimera can have two different colored eyes just like any two siblings can—because each cell has different eye color genes. A Mosaic (genetics), mosaic can have two different colored eyes if the DNA difference happens to be in an eye-color gene.

There are many other possible reasons for having two different-colored eyes. For example, the film actor Lee Van Cleef was born with one blue eye and one green eye, a trait that reportedly was common in his family, suggesting that it was a genetic trait. This anomaly, which film producers thought would be disturbing to film audiences, was "corrected" by having Van Cleef wear brown contact lenses. David Bowie, on the other hand, had the appearance of different eye colors due to an injury that caused one pupil to be permanently dilated.

Another hypothesis about heterochromia is that it can result from a viral infection ''in utero'' affecting the development of one eye, possibly through some sort of genetic mutation. Occasionally, heterochromia can be a sign of a serious medical condition.

A common cause in females with heterochromia is X-inactivation, which can result in a number of heterochromatic traits, such as calico cats. Trauma and certain medications, such as some prostaglandin analogues, can also cause increased pigmentation in one eye. On occasion, a difference in eye color is caused by blood staining the iris after injury.

Mate selection and traits that have been linked to iris color

Selection for rare iris colors

A study compared the frequency of eye color in commercial advertising models in Brazil and the UK; these countries were chosen because they have inverted frequencies of eye-coloration, with Brazil having an excess of brown and the UK an excess of light-colored eyes. Models are chosen for their attractiveness, and it was found that, in Brazil, models with light eyes are in a significant excess compared to the levels found in the general population, while, in the UK, models with brown or intermediate eyes were in significant excess over their frequency in the general population. This suggests that eye color rarity plays a role in sexual attraction, people with rare eye colors being perceived as being more attractive. Which may reflect sexual selection of mates with rare eye colors.

Impact on vision

Although people with lighter eye color are generally more sensitive to light because they have less pigment in the iris to protect them from sunlight, there is little to no evidence that eye color has a direct impact on vision qualities such as visual acuity. However, there is a study that found that dark-eyed people perform better at "reactive-type tasks", which suggests they may have better reaction times. People with light-colored eyes, however, performed better at so-called "self-paced tasks", which include activities like hitting a golf ball or throwing baseballs. In another study, people with darker eyes performed better at hitting racquetballs. There are also other studies that challenge those findings. According to scientists, more study is needed to verify these results.

See also

* Hair color
* Iridology
* Human skin color
* Xanthophore
* List of Mendelian traits in humans

References

External links

genetics.thetech.org

{{DEFAULTSORT:Eye Color
Eye color,
Eye
Facial features
Color