The Centre for Human Genetics (CHG) is a

human genetics Human genetics is the study of inheritance as it occurs in Human, human beings. Human genetics encompasses a variety of overlapping fields including: classical genetics, cytogenetics, molecular genetics, biochemical genetics, genomics, populatio ...

research centre of the Nuffield Department of Medicine in the

Medical Sciences Division, University of Oxford The various academic faculties, departments, and institutes of the University of Oxford are organised into four divisions, each with its own Head and elected board. They are the Humanities Division; the Social Sciences Division; the Mathematical ...

, funded by the

Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of Burroughs Wellcome, one of the predec ...

among others. Henry Wellcome Building for Genomic Medicine

Facilities & resources

The centre is located at the

Henry Wellcome Sir Henry Solomon Wellcome (21 August 1853 – 25 July 1936) was an American and British pharmaceutical entrepreneur. He founded the pharmaceutical company Burroughs Wellcome & Company with his colleague Silas Mainville Burroughs, Jr., Silas Bur ...

Building of Genomic Medicine, which cost £20 million and was officially opened in June 2000 with Anthony Monaco as the director. Within the CHG a number of 'cores' provide services to the researchers:

Oxford Genomics Centre

The Oxford Genomics Centre provides high throughput sequencing services, using Illumina HiSeq4000 2500 and NextSeq500 and MiSeq. They also offer Oxford Nanopore MinION and PromethION sequencing. There are also Array platforms for genotyping, gene expression, and methylation including Illuminia Infinium,

Affymetrix Affymetrix is now Applied Biosystems, a brand of DNA microarray products sold by Thermo Fisher Scientific that originated with an American biotechnology research and development and manufacturing company of the same name. The Santa Clara, Calif ...

and

Fluidigm Standard BioTools Inc., previously known as Fluidigm Corp., is an American life science tools company that offers analytical mass cytometry systems for flow cytometry and tissue imaging, along with associated assays and reagents, as well as an a ...

Research Computing Core

The Research Computing Core provides access to computer resources including 4120 cores and 4.2 PB of storage.

Transgenics

The Transgenics Core provides access to genetically modified mice and cell lines.

Cellular Imaging

Cellular Imaging Core provides microscopy facilities including fluorescence microscopy (including Fluorescence Correlation Spectroscopy ( FCS), Fluorescence Lifetime Correlation Spectroscopy ( FLCS), Fluorescence Lifetime Imaging Microscopy ( FLIM), Total Internal Reflection Fluorescence Microscopy ( TIRF), Photoactivated Localisation Microscopy (

PALM Palm most commonly refers to: * Palm of the hand, the central region of the front of the hand * Palm plants, of family Arecaceae ** List of Arecaceae genera **Palm oil * Several other plants known as "palm" Palm or Palms may also refer to: Music ...

), Spectral Imaging ( SI) and Single Particle Tracking (

SPT SPT may refer to: Organisations * Society for Philosophy and Technology * Strathclyde Partnership for Transport, Scotland * Sunpentown, a Taiwanese appliance manufacturer Science and technology * Septic pelvic thrombophlebitis, a postpartum co ...

Research

Statistical and population genetics

The CHG has been involved in many international statistical genetics advances including the Wellcome Trust Case Control Consortia (WTCCC, WTCCC2), the

1000 Genomes Project The 1000 Genomes Project (1KGP), taken place from January 2008 to 2015, was an international research effort to establish the most detailed catalogue of human genetic variation at the time. Scientists planned to sequence the genomes of at least o ...

and the International

HapMap Project The International HapMap Project was an organization that aimed to develop a haplotype map (HapMap) of the human genome, to describe the common patterns of human genetic variation. HapMap is used to find genetic variants affecting health, disease ...

References

{{authority control 1994 establishments in England Biotechnology in the United Kingdom Departments of the University of Oxford Educational institutions established in 1994 Genetics in the United Kingdom Genetics or genomics research institutions Research institutes in Oxford Wellcome Trust Medical research institutes in the United Kingdom Human genetics