Wallace B. Mendelson
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Wallace B. Mendelson is an American psychiatrist and author. Working primarily in the fields of sleep research and psychopharmacology, he most recently worked at the
Pritzker School of Medicine The University of Chicago Pritzker School of Medicine is the M.D.-granting unit under the Biological Sciences Division of the University of Chicago. It is located on the university's main campus in the Hyde Park neighborhood of Chicago and mat ...
as a professor of psychiatry and clinical pharmacology and the director of the school's Sleep Research Laboratory. He is the author of sixteen books and numerous papers in the fields of sleep science, pharmacology and history of science.


Education

Mendelson earned his Bachelor of Arts in 1965 from the
University of Texas at Austin The University of Texas at Austin (UT Austin, UT, or Texas) is a public university, public research university in Austin, Texas, United States. Founded in 1883, it is the flagship institution of the University of Texas System. With 53,082 stud ...
. He then went on to
Washington University in St. Louis Washington University in St. Louis (WashU) is a private research university in St. Louis, Missouri, United States. Founded in 1853 by a group of civic leaders and named for George Washington, the university spans 355 acres across its Danforth ...
where he earned his
Doctor of Medicine A Doctor of Medicine (abbreviated MD, from the Latin language, Latin ) is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the ''MD'' denotes a professional degree of ph ...
in 1969. He completed his residency in psychiatry and taught at
Washington University School of Medicine Washington University School of Medicine (WashU Medicine) is the medical school of Washington University in St. Louis, located in the Central West End neighborhood of St. Louis, Missouri. Founded in 1891, the School of Medicine shares a ca ...
.


Career

After Washington University, in 1975 Mendelson took a position at the Intramural Program of the
National Institute of Mental Health The National Institute of Mental Health (NIMH) is one of 27 institutes and centers that make up the National Institutes of Health (NIH). The NIH, in turn, is an agency of the United States Department of Health and Human Services and is the primar ...
(NIMH) in
Bethesda, Maryland Bethesda () is an unincorporated, census-designated place in southern Montgomery County, Maryland, United States. Located just northwest of Washington, D.C., it is a major business and government center of the Washington metropolitan region ...
where he was the Chief, Section on Sleep Studies until 1987. While with the NIMH, Mendelson published two books: ''Human Sleep and Its Disorders'' (1977) and ''The Use and Misuse of Sleeping Pills'' (1980). After the NIMH, Mendelson became the director of the Center for the Study of Sleep and Waking at
Stony Brook University Stony Brook University (SBU), officially the State University of New York at Stony Brook, is a public university, public research university in Stony Brook, New York, United States, on Long Island. Along with the University at Buffalo, it is on ...
and held a professorship there. He also published his third book while at Stony Brook called ''Human Sleep: Research and Clinical Care'' in 1987. In 1994, he was named the director of the Sleep Disorders Center at the
Cleveland Clinic Cleveland Clinic is an American Nonprofit organization, nonprofit Academic health science center, academic Medical centers in the United States, medical center based in Cleveland, Ohio. Owned and operated by the Cleveland Clinic Foundation, an O ...
in
Cleveland Cleveland is a city in the U.S. state of Ohio and the county seat of Cuyahoga County. Located along the southern shore of Lake Erie, it is situated across the Canada–U.S. maritime border and approximately west of the Ohio-Pennsylvania st ...
, Ohio. From 1997 to 1998, Mendelson served as the President of the
Sleep Research Society The Sleep Research Society (SRS) is an organization that promotes the science of sleep and related disorders. Additionally, the SRS is dedicated to the training and education of future sleep researchers Organization The organization traces it ...
. He began working at the University of Chicago as a professor of psychiatry and clinical pharmacology and the director of the Sleep Research Laboratory. He retired from full-time university work in the early 2000s and has subsequently been writing, consulting, and in the part-time practice of general psychiatry. During his tenures at Stony Brook, the Cleveland Clinic, and The University of Chicago, he set up three accredited fellowship training programs in sleep medicine. Since 2017, Mendelson published a number of books, including ''The Science of Sleep'', ''Understanding Antidepressants'', ''Understanding Sleeping Pills'', ''Understanding Medicines for Anxiety'', ''The Curious History of Medicines in Psychiatry'', ''Molecules, Madness, and Malaria,'' ''Nepenthe's Children, Trial by Fire,'' ''Fragile Brilliance,'' ''The Psychoanalyst and The Nazi Nobelist,'' ''The Battle Over the Butterflies of the Soul,'' ''From Despair to Discovery'' and ''Pharmacy of the Mind''


Research

Mendelson is known for basic science studies elucidating the effects of
inverse agonists In pharmacology, an inverse agonist is a drug that binds to the same receptor as an agonist but induces a pharmacological response opposite to that of the agonist. A neutral antagonist has no activity in the absence of an agonist or inverse agon ...
of the
benzodiazepine receptor The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous Ligand (biochemistry), ligand is γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. Accurate regul ...
, the actions of endogenous ligands for benzodiazepine receptors, and the role of the medial
preoptic area The preoptic area is a region of the hypothalamus. MeSH classifies it as part of the anterior hypothalamus. TA lists four nuclei in this region, (medial, median, lateral, and periventricular). Functions The preoptic area is responsible for the ...
in pharmacologic sleep induction. At a human research level he characterized differences in regulation of growth hormone secretion during sleep and waking, effects of drugs on the perception of being awake or asleep, the interaction of sleep and depression, and the clinical properties of sleep-inducing medicines. Mendelson has been described as a "pioneer in the field of sleep research and sleep medicine, and is a well-respected psychiatrist, scientist, and sleep educator." In 2022 he was designated a ‘Living Legend in Sleep Research’ by the journal Sleep Advances in which he published a history of his work, memories of colleagues and mentors, and thoughts for the future.


Bibliography


References


External links


Official website
{{DEFAULTSORT:Mendelson, Wallace B. Living people 1945 births American male writers American psychiatrists Stony Brook University faculty University of Chicago faculty University of Texas at Austin alumni Washington University School of Medicine faculty Washington University School of Medicine alumni