VPS11
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Vacuolar protein sorting-associated protein 11 homolog is a
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''VPS11''
gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.


Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.


Interactions

VPS11 has been shown to
interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with
VPS18 Vacuolar protein sorting-associated protein 18 homolog is a protein that in humans is encoded by the ''VPS18'' gene. Function Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct orga ...
,
VPS33A Vacuolar protein sorting-associated protein 33A is a protein that in humans is encoded by the ''VPS33A'' gene. Function Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles ...
and
STX7 Syntaxin-7 is a protein that in humans is encoded by the ''STX7'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to ...
.


References


Further reading

* * * * * * * * {{Gene-11-stub