Translational research (also called translation research, translational science, or, when the context is clear, simply translation) is research aimed at translating (converting) results in basic research into results that directly benefit humans. The term is used in

science Science is a systematic discipline that builds and organises knowledge in the form of testable hypotheses and predictions about the universe. Modern science is typically divided into twoor threemajor branches: the natural sciences, which stu ...

and

technology Technology is the application of Conceptual model, conceptual knowledge to achieve practical goals, especially in a reproducible way. The word ''technology'' can also mean the products resulting from such efforts, including both tangible too ...

, especially in

biology Biology is the scientific study of life and living organisms. It is a broad natural science that encompasses a wide range of fields and unifying principles that explain the structure, function, growth, History of life, origin, evolution, and ...

and medical science. As such, translational research forms a subset of applied research. The term has been used most commonly in life sciences and biotechnology, but applies across the spectrum of science and humanities. In the context of biomedicine, translational research is also known as bench to bedside. In the field of education, it is defined as research which translates concepts to classroom practice. Critics of translational medical research (to the exclusion of more basic research) point to examples of important drugs that arose from fortuitous discoveries in the course of basic research such as

penicillin Penicillins (P, PCN or PEN) are a group of beta-lactam antibiotic, β-lactam antibiotics originally obtained from ''Penicillium'' Mold (fungus), moulds, principally ''Penicillium chrysogenum, P. chrysogenum'' and ''Penicillium rubens, P. ru ...

and benzodiazepines. Other problems have stemmed from the widespread irreproducibility thought to exist in translational research literature. Although translational research is relatively new, there are now several major research centers focused on it. In the U.S., the

National Institutes of Health The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...

has implemented a major national initiative to leverage existing academic health center infrastructure through the Clinical and Translational Science Awards. Furthermore, some universities acknowledge translational research as its own field in which to study for a PhD or graduate certificate.

Definitions

Translational research is aimed at solving particular problems; the term has been used most commonly in life sciences and biotechnology, but applies across the spectrum of science and humanities. In the field of education, it is defined for school-based education by the Education Futures Collaboration (www.meshguides.org) as research which translates concepts to classroom practice. Examples of translational research are commonly found in education subject association journals and in the MESHGuides which have been designed for this purpose. In bioscience, translational research is a term often used interchangeably with translational medicine or translational science or bench to bedside. The

adjective An adjective (abbreviations, abbreviated ) is a word that describes or defines a noun or noun phrase. Its semantic role is to change information given by the noun. Traditionally, adjectives are considered one of the main part of speech, parts of ...

"translational" refers to the " translation" (the term derives from the

Latin Latin ( or ) is a classical language belonging to the Italic languages, Italic branch of the Indo-European languages. Latin was originally spoken by the Latins (Italic tribe), Latins in Latium (now known as Lazio), the lower Tiber area aroun ...

for "carrying over") of basic scientific findings in a laboratory setting into potential treatments for disease. Biomedical translational research adopts a scientific investigation/enquiry into a given problem facing medical/health practices: it aims to "translate" findings in fundamental research into practice. In the field of biomedicine, it is often called "translational medicine", defined by the European Society for Translational Medicine (EUSTM) as "an interdisciplinary branch of the biomedical field supported by three main pillars: benchside, bedside and community", from laboratory experiments through clinical trials, to therapies, to point-of-care patient applications. The end point of translational research in medicine is the production of a promising new treatment that can be used clinically. Translational research is conceived due to the elongated time often taken to bring to bear discovered medical idea in practical terms in a health system. It is for these reasons that translational research is more effective in dedicated university science departments or isolated, dedicated research centers. Since 2009, the field has had specialized journals, the '' American Journal of Translational Research'' and '' Translational Research'' dedicated to translational research and its findings. Translational research in biomedicine is broken down into different stages. In a two-stage model, ''T1 research'', refers to the "bench-to-bedside" enterprise of translating knowledge from the basic sciences into the development of new treatments and ''T2 research'' refers to translating the findings from clinical trials into everyday practice, although this model is actually referring to the 2 "roadblocks" T1 and T2. Waldman et al. propose a scheme going from T0 to T5. T0 is laboratory (before human) research. In T1-translation, new laboratory discoveries are first translated to human application, which includes phase I & II clinical trials. In T2-translation, candidate health applications progress through clinical development to engender the evidence base for integration into clinical practice guidelines. This includes phase III clinical trials. In T3-translation, dissemination into community practices happens. T4-translation seeks to (1) advance scientific knowledge to paradigms of disease prevention, and (2) move health practices established in T3 into population health impact. Finally, T5-translation focuses on improving the wellness of populations by reforming suboptimal social structures

Comparison to basic research or applied research

Basic research is the systematic study directed toward greater

knowledge Knowledge is an Declarative knowledge, awareness of facts, a Knowledge by acquaintance, familiarity with individuals and situations, or a Procedural knowledge, practical skill. Knowledge of facts, also called propositional knowledge, is oft ...

or understanding of the fundamental aspects of phenomena and is performed without thought of practical ends. It results in general knowledge and understanding of nature and its laws. For instance, basic biomedical research focuses on studies of disease processes using, for example, cell cultures or animal models without consideration of the potential utility of that information. Applied research is a form of systematic inquiry involving the practical application of

. It accesses and uses the research communities' accumulated theories, knowledge, methods, and techniques, for a specific, often stated,

business Business is the practice of making one's living or making money by producing or Trade, buying and selling Product (business), products (such as goods and Service (economics), services). It is also "any activity or enterprise entered into for ...

, or client-driven purpose. Translational research forms a subset of applied research. In life-sciences, this was evidenced by a citation pattern between the applied and basic sides in cancer research that appeared around 2000. In fields such as psychology, translational research is seen as a bridging between applied research and basic research types. The field of psychology defines translational research as the use of basic research to develop and test applications, such as treatment.

Challenges and criticisms

Critics of translational medical research (to the exclusion of more basic research) point to examples of important drugs that arose from fortuitous discoveries in the course of basic research such as

and benzodiazepines, and the importance of basic research in improving our understanding of basic biological facts (e.g. the function and structure of DNA) that go on to transform applied medical research. Examples of failed translational research in the pharmaceutical industry include the failure of anti-aβ therapeutics in Alzheimer's disease. Other problems have stemmed from the widespread irreproducibility thought to exist in translational research literature.

Translational research-facilities in life-sciences

In U.S., the

has implemented a major national initiative to leverage existing academic health center infrastructure through the Clinical and Translational Science Awards. The National Center for Advancing Translational Sciences (NCATS) was established on December 23, 2011. Although translational research is relatively new, it is being recognized and embraced globally. Some major centers for translational research include: * About 60 hubs of the Clinical and Translational Science Awards program. * Texas Medical Center,

Houston, Texas Houston ( ) is the List of cities in Texas by population, most populous city in the U.S. state of Texas and in the Southern United States. Located in Southeast Texas near Galveston Bay and the Gulf of Mexico, it is the county seat, seat of ...

, United States * Translational Research Institute (Australia), Brisbane, Queensland,

Australia Australia, officially the Commonwealth of Australia, is a country comprising mainland Australia, the mainland of the Australia (continent), Australian continent, the island of Tasmania and list of islands of Australia, numerous smaller isl ...

. * University of Rochester,

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, United States has a dedicated Clinical and Translational Science Institute * Stanford University Medical Center, Stanford, California, United States. * Translational Genomics Research Institute,

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, United States. * Maine Medical Center in

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, United States has a dedicated translational research institute. * Scripps Research Institute,

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, United States, has a dedicated translational research institute. * UC Davis Clinical and Translational Science Center,

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* Clinical and Translational Science Institute, University of Pittsburgh,

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* Weill Cornell Medicine has a Clinical and Translational Science Center. * Hansjörg Wyss Institute for Biologically Inspired Engineering at Harvard University in Boston, Massachusetts, United States. Additionally, translational research is now acknowledged by some universities as a dedicated field to study a PhD or graduate certificate in, in a medical context. These institutes currently include Monash University in Victoria, Australia, the

University of Queensland The University of Queensland is a Public university, public research university located primarily in Brisbane, the capital city of the Australian state of Queensland. Founded in 1909 by the Queensland parliament, UQ is one of the six sandstone ...

, Diamantina Institute in Brisbane, Australia, at Duke University in

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, America, at Creighton University in

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Emory University Emory University is a private university, private research university in Atlanta, Georgia, United States. It was founded in 1836 as Emory College by the Methodist Episcopal Church and named in honor of Methodist bishop John Emory. Its main campu ...

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, and at The George Washington University in Washington, D.C. The industry and academic interactions to promote translational science initiatives has been carried out by various global centers such as

European Commission The European Commission (EC) is the primary Executive (government), executive arm of the European Union (EU). It operates as a cabinet government, with a number of European Commissioner, members of the Commission (directorial system, informall ...

, GlaxoSmithKline and Novartis Institute for Biomedical Research.

References

External links