Thyroglobulin type-1 repeat is an evolutionary conserved
protein domain
In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist o ...
.
Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.
Human proteins containing this domain
CD74;
IGFBP-4;
IGFBP1;
IGFBP2;
IGFBP3
Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the ''IGFBP3'' gene. IGFBP-3 is one of six insulin-like growth factor-binding protein, IGF binding proteins (IGFBP1, IGFBP-1 to IGFBP6, I ...
;
IGFBP4;
IGFBP5;
IGFBP6;
NID1;
NID2;
SMOC1;
SMOC2;
SPOCK1;
SPOCK2;
SPOCK3;
TACSTD1;
TACSTD2;
TG;
References
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Protein domains
Single-pass transmembrane proteins
{{membrane-protein-stub