The Frythe is a

country house image:Blenheim - Blenheim Palace - 20210417125239.jpg, 300px, Blenheim Palace - Oxfordshire An English country house is a large house or mansion in the English countryside. Such houses were often owned by individuals who also owned a Townhou ...

set in its own grounds in rural

Hertfordshire Hertfordshire ( or ; often abbreviated Herts) is a ceremonial county in the East of England and one of the home counties. It borders Bedfordshire to the north-west, Cambridgeshire to the north-east, Essex to the east, Greater London to the ...

, just south of the village of

Welwyn Welwyn is a village and civil parish in Hertfordshire, England. The parish also includes the nearby villages and settlements of Digswell, Mardley Heath and Oaklands. The village is sometimes referred to as Old Welwyn or Welwyn Village, to ...

, about 30 miles north of

London London is the Capital city, capital and List of urban areas in the United Kingdom, largest city of both England and the United Kingdom, with a population of in . London metropolitan area, Its wider metropolitan area is the largest in Wester ...

History

Early history

The Frythe was part of the property of Holywell Priory, Shoreditch, and in 1523 William Wilshere obtained a sixty-year lease of the Frythe from the priory. As a result of the dissolution of the monasteries, in 1539 the property was granted to Sir John Gostwick and Joan his wife. Within ten years, Wilshere had purchased The Frythe from Gostwick's heirs, and the property remained in the possession of the Wilshere family for several centuries. The present "Gothic revival" mansion was built in 1846 for William Wilshere (MP for

Great Yarmouth Great Yarmouth ( ), often called Yarmouth, is a seaside resort, seaside town which gives its name to the wider Borough of Great Yarmouth in Norfolk, England; it straddles the River Yare and is located east of Norwich. Its fishing industry, m ...

from 1837 to 1846). The architects were Thomas Smith and

Edward Blore Edward Blore (13 September 1787 – 4 September 1879) was a 19th-century English landscape and architectural artist, architect and antiquary. Early career Blore was born in Derby, the son of the antiquarian writer Thomas Blore. Blore's backg ...

. After William Wilshere's death in 1867 the house was enlarged by his brother Charles Willes Wilshere who inherited it. In 1908 on Charles Wilshere's death, it passed on to his three unmarried daughters, until the last one died in 1934. The estate passed to a great-nephew, Captain Gerald Maunsell Gamul Farmer, of a landed gentry family of Nonsuch, Surrey, who adopted the surname of Wilshere, and ran the house as "The Frythe Residential and Private Hotel".

SOE Station IX

'The Frythe' was commandeered in August 1939 by the British

military intelligence Military intelligence is a military discipline that uses information collection and analysis List of intelligence gathering disciplines, approaches to provide guidance and direction to assist Commanding officer, commanders in decision making pr ...

. During the

Second World War World War II or the Second World War (1 September 1939 – 2 September 1945) was a World war, global conflict between two coalitions: the Allies of World War II, Allies and the Axis powers. World War II by country, Nearly all of the wo ...

it became a secret British

Special Operations Executive Special Operations Executive (SOE) was a British organisation formed in 1940 to conduct espionage, sabotage and reconnaissance in German-occupied Europe and to aid local Resistance during World War II, resistance movements during World War II. ...

factory known as Station IX making commando equipment. Secret research included military vehicles and equipment, explosives and technical sabotage,

camouflage Camouflage is the use of any combination of materials, coloration, or illumination for concealment, either by making animals or objects hard to see, or by disguising them as something else. Examples include the leopard's spotted coat, the b ...

biological Biology is the scientific study of life and living organisms. It is a broad natural science that encompasses a wide range of fields and unifying principles that explain the structure, function, growth, origin, evolution, and distribution of ...

and chemical warfare. In the grounds of The Frythe small cabins and barracks functioned as laboratories and workshops.

Research facility

The Frythe was for many years a commercial research facility, operated by ICI from 1946, known as 'Akers Research Laboratories' from around 1955, named after Sir

Wallace Akers Sir Wallace Alan Akers (9 September 1888 – 1 November 1954) was a British chemist and industrialist. Beginning his academic career at Oxford he specialized in physical chemistry. During the Second World War, he was the director of the Tube Al ...

, who had died in 1954. From 1963 it was owned by

Unilever Unilever PLC () is a British multinational consumer packaged goods company headquartered in London, England. It was founded on 2 September 1929 following the merger of Dutch margarine producer Margarine Unie with British soap maker Lever B ...

, and by

Smith, Kline & French Smith, Kline & French (SKF) was an American pharmaceutical company that is now a part of the British group GSK plc. History In 1830, John K. Smith opened a drugstore in Philadelphia, and his younger brother, George, joined him in 1841 to form ...

from 1977.

Unilever

From 1946 to 1963 the site was shared by ICI with

. New buildings were built by Unilever in the 1960s, with a contract for £400,000 in 1964 to

Taylor Woodrow Taylor Woodrow was one of the largest housebuilding and general construction companies in Britain. It was listed on the London Stock Exchange and was a constituent of the FTSE 100 Index until its merger with rival housebuilder George Wimpey ...

. Research was conducted on edible oils, margarine, ice cream, and frozen foods in the 1960s. Techniques included

molecular biophysics Molecular biophysics is a rapidly evolving interdisciplinary area of research that combines concepts in physics, chemistry, engineering, mathematics and biology. It seeks to understand biomolecular systems and explain biological function in ter ...

X-ray crystallography X-ray crystallography is the experimental science of determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to Diffraction, diffract in specific directions. By measuring th ...

nuclear magnetic resonance spectroscopy Nuclear magnetic resonance spectroscopy, most commonly known as NMR spectroscopy or magnetic resonance spectroscopy (MRS), is a Spectroscopy, spectroscopic technique based on re-orientation of Atomic nucleus, atomic nuclei with non-zero nuclear sp ...

(NMR),

mass spectrometry Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. The results are presented as a ''mass spectrum'', a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is used ...

, ESR spectroscopy (

electron paramagnetic resonance Electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy is a method for studying materials that have unpaired electrons. The basic concepts of EPR are analogous to those of nuclear magnetic resonance (NMR), but the spin ...

), and

infrared spectroscopy Infrared spectroscopy (IR spectroscopy or vibrational spectroscopy) is the measurement of the interaction of infrared radiation with matter by absorption, emission, or reflection. It is used to study and identify chemical substances or functio ...

GSK

discovered Tagamet (

Cimetidine Cimetidine, sold under the brand name Tagamet among others, is a histamine H2 receptor antagonist that inhibits stomach acid production. It is mainly used in the treatment of heartburn and peptic ulcers. With the development of proton pump ...

) at The Frythe in 1971, which treats

peptic ulcers Peptic ulcer disease is when the inner part of the stomach's gastric mucosa (lining of the stomach), the first part of the small intestine, or sometimes the lower esophagus, gets damaged. An ulcer in the stomach is called a gastric ulcer, while ...

by Sir James Black FRS and C. Robin Ganellin FRS with research on

H2 antagonist H2 antagonists, sometimes referred to as H2RAs and also called H2 blockers, are a class of medications that block the action of histamine at the histamine H2 receptors of the parietal cells in the stomach. This decreases the production of stoma ...

Residential Accommodation

The Frythe site was closed by

GlaxoSmithKline GSK plc (an acronym from its former name GlaxoSmithKline plc) is a British Multinational corporation, multinational Pharmaceutics, pharmaceutical and biotechnology company with headquarters in London. It was established in 2000 by a Mergers an ...

and sold to a property development company on 19 December 2010. In 2017, the conversion of the property into flats was still underway.

References

* {{DEFAULTSORT:Frythe Buildings and structures in Welwyn Hatfield (district) Country houses in Hertfordshire Edward Blore buildings GSK plc Gothic Revival architecture in Hertfordshire Houses completed in 1846 Imperial Chemical Industries Military history of Hertfordshire Pharmaceutical industry in the United Kingdom Pharmaceutical research institutes Research institutes in Hertfordshire Special Operations Executive Locations in the history of espionage Unilever World War II sites in England