Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a
protein that in humans is encoded by the ''SREBF2''
gene.
Function
This gene encodes a ubiquitously expressed
transcription factor that controls
cholesterol homeostasis
In biology, homeostasis (British also homoeostasis) (/hɒmɪə(ʊ)ˈsteɪsɪs/) is the state of steady internal, physical, and chemical conditions maintained by living systems. This is the condition of optimal functioning for the organism and i ...
by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix leucine zipper (
bHLH-Zip) domain.
Various
single nucleotide polymorphisms (SNPs) of the SREBF2 have been identified and some of them are found to be associated with higher risk of knee
osteoarthritis.
Interactions
SREBF2 has been shown to
interact
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with
INSIG1
Insulin induced gene 1, also known as INSIG1, is a protein which in humans is encoded by the ''INSIG1'' gene.
INSIG1 is short for insulin-induced gene 1; it is located on chromosome 7 (7q36). This human gene encodes for a transmembrane protein ...
and
CREB-binding protein
Cyclic adenosine monophosphate Response Element Binding protein Binding Protein (CREB-binding protein), also known as CREBBP or CBP or KAT3A, is a coactivator encoded by the ''CREBBP'' gene in humans, located on chromosome 16p13.3. CBP has intrin ...
.
See also
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Sterol regulatory element-binding protein
Sterol regulatory element-binding proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA sequence TCACNCCAC. Mammalian SREBPs are encoded by the genes ''SREBF1'' and ''SREBF2''. SREBPs belong to the basic- ...
References
Further reading
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External links
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{{Transcription factors, g1
Transcription factors