A separation process is a method that converts a

mixture In chemistry, a mixture is a material made up of two or more different chemical substances which are not chemically bonded. A mixture is the physical combination of two or more substances in which the identities are retained and are mixed in the ...

or a solution of chemical substances into two or more distinct product mixtures, a scientific process of separating two or more substance in order to obtain purity. At least one product mixture from the separation is enriched in one or more of the source mixture's constituents. In some cases, a separation may fully divide the mixture into pure constituents. Separations exploit differences in chemical properties or physical properties (such as size, shape, mass, density, or chemical affinity) between the constituents of a mixture. Processes are often classified according to the particular properties they exploit to achieve separation. If no single difference can be used to accomplish the desired separation, multiple operations can often be combined to achieve the desired end. With a few exceptions, elements or

compound Compound may refer to: Architecture and built environments * Compound (enclosure), a cluster of buildings having a shared purpose, usually inside a fence or wall ** Compound (fortification), a version of the above fortified with defensive struc ...

s exist in nature in an impure state. Often these raw materials must go through a separation before they can be put to productive use, making separation techniques essential for the modern industrial economy. The purpose of separation may be: * ''analytical'': to identify the size of each fraction of a mixture is attributable to each component without attempting to harvest the fractions. * ''preparative'': to "prepare" fractions for input into processes that benefit when components are separated. Separations may be performed on a small scale, as in a

laboratory A laboratory (; ; colloquially lab) is a facility that provides controlled conditions in which scientific or technological research, experiments, and measurement may be performed. Laboratory services are provided in a variety of settings: physicia ...

for analytical purposes, or on a large scale, as in a

Chemical plant A chemical plant is an industrial process plant that manufactures (or otherwise processes) chemicals, usually on a large scale. The general objective of a chemical plant is to create new material wealth via the chemical or biological transfor ...

Complete and incomplete separation

Some types of separation require complete purification of a certain component. An example is the production of

aluminum Aluminium (aluminum in American and Canadian English) is a chemical element with the symbol Al and atomic number 13. Aluminium has a density lower than those of other common metals, at approximately one third that of steel. It h ...

metal from

bauxite Bauxite is a sedimentary rock with a relatively high aluminium content. It is the world's main source of aluminium and gallium. Bauxite consists mostly of the aluminium minerals gibbsite (Al(OH)3), boehmite (γ-AlO(OH)) and diaspore (α-AlO(OH ...

ore through electrolysis refining. In contrast, an incomplete separation process may specify an output to consist of a mixture instead of a single pure component. A good example of an incomplete separation technique is

oil An oil is any nonpolar chemical substance that is composed primarily of hydrocarbons and is hydrophobic (does not mix with water) & lipophilic (mixes with other oils). Oils are usually flammable and surface active. Most oils are unsaturated ...

refining. Crude oil occurs naturally as a mixture of various

hydrocarbon In organic chemistry, a hydrocarbon is an organic compound consisting entirely of hydrogen and carbon. Hydrocarbons are examples of group 14 hydrides. Hydrocarbons are generally colourless and hydrophobic, and their odors are usually weak or ...

s and impurities. The refining process splits this mixture into other, more valuable mixtures such as

natural gas Natural gas (also called fossil gas or simply gas) is a naturally occurring mixture of gaseous hydrocarbons consisting primarily of methane in addition to various smaller amounts of other higher alkanes. Low levels of trace gases like carbon di ...

gasoline Gasoline (; ) or petrol (; ) (see ) is a transparent, petroleum-derived flammable liquid that is used primarily as a fuel in most spark-ignited internal combustion engines (also known as petrol engines). It consists mostly of organic com ...

and chemical feedstocks, none of which are pure substances, but each of which must be separated from the raw crude. In both cases of complete and incomplete separation, a series of separations may be necessary to obtain the desired end products. In the case of oil refining, crude is subjected to a long series of individual

distillation Distillation, or classical distillation, is the process of separating the components or substances from a liquid mixture by using selective boiling and condensation, usually inside an apparatus known as a still. Dry distillation is the heating ...

steps, each of which produces a different product or intermediate.

List of separation techniques

Sponge Sponges, the members of the phylum Porifera (; meaning 'pore bearer'), are a basal animal clade as a sister of the diploblasts. They are multicellular organisms that have bodies full of pores and channels allowing water to circulate through ...

, adhesion of atoms, ions or molecules of gas, liquid, or dissolved solids to a surface *

Centrifugation Centrifugation is a mechanical process which involves the use of the centrifugal force to separate particles from a solution according to their size, shape, density, medium viscosity and rotor speed. The denser components of the mixture migrate ...

and

cyclonic separation Cyclonic separation is a method of removing particulates from an air, gas or liquid stream, without the use of filters, through vortex separation. When removing particulate matter from liquid, a hydrocyclone is used; while from gas, a gas cyclo ...

, separates based on density differences *

Chelation Chelation is a type of bonding of ions and molecules to metal ions. It involves the formation or presence of two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central metal atom. These ligands are ...

Filtration Filtration is a physical separation process that separates solid matter and fluid from a mixture using a ''filter medium'' that has a complex structure through which only the fluid can pass. Solid particles that cannot pass through the filter m ...

Chromatography

Chromatography separates dissolved substances by different interaction with (i.e., travel through) a material. *

High-performance liquid chromatography High-performance liquid chromatography (HPLC), formerly referred to as high-pressure liquid chromatography, is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to p ...

(HPLC) *

Thin-layer chromatography Thin-layer chromatography (TLC) is a chromatography technique used to separate non-volatile mixtures. Thin-layer chromatography is performed on a sheet of an inert substrate such as glass, plastic, or aluminium foil, which is coated with a t ...

(TLC) *

Countercurrent chromatography Countercurrent chromatography (CCC, also counter-current chromatography) is a form of liquid–liquid chromatography that uses a liquid stationary phase that is held in place by inertia of the molecules composing the stationary phase accelerating ...

(CCC) *

Droplet countercurrent chromatography Droplet countercurrent chromatography (DCCC or DCC) was introduced in 1970 by Tanimura, Pisano, Ito, and Bowman. DCCC is considered to be a form of liquid-liquid separation, which includes countercurrent distribution and countercurrent chromatogra ...

(DCC) *

Paper chromatography Paper chromatography is an analytical method used to separate coloured chemicals or substances. It is now primarily used as a teaching tool, having been replaced in the laboratory by other chromatography methods such as thin-layer chromatography ...

Ion chromatography Ion chromatography (or ion-exchange chromatography) separates ions and polar molecules based on their affinity to the ion exchanger. It works on almost any kind of charged molecule—including large proteins, small nucleotides, and amino aci ...

Size-exclusion chromatography Size-exclusion chromatography (SEC), also known as molecular sieve chromatography, is a chromatographic method in which molecules in solution are separated by their size, and in some cases molecular weight. It is usually applied to large molecul ...

Affinity chromatography Affinity chromatography is a method of separating a biomolecule from a mixture, based on a highly specific macromolecular binding interaction between the biomolecule and another substance. The specific type of binding interaction depends on the ...

Centrifugal partition chromatography Centrifugal partition chromatography is a special chromatographic technique where both stationary and mobile phase are liquid, and the stationary phase is immobilized by a strong centrifugal force. Centrifugal partition chromatography consists of a ...

Gas chromatography Gas chromatography (GC) is a common type of chromatography used in analytical chemistry for separating and analyzing compounds that can be vaporized without decomposition. Typical uses of GC include testing the purity of a particular substance, ...

and

Inverse gas chromatography Inverse gas chromatography is a physical characterization analytical technique that is used in the analysis of the surfaces of solids. Inverse gas chromatography or IGC is a highly sensitive and versatile gas phase technique developed over 40 yea ...

* Crystallization *

Decantation Decantation is a process for the separation of mixtures of immiscible liquids or of a liquid and a solid mixture such as a suspension. The layer closer to the top of the container—the less dense of the two liquids, or the liquid from which th ...

Demister (vapor) A demister is a device often fitted to vapor–liquid separator vessels to enhance the removal of liquid droplets entrained in a vapor stream. Demisters may be a mesh-type coalescer, vane pack or other structure intended to aggregate the mist i ...

, removes liquid droplets from gas streams *

Distillation Distillation, or classical distillation, is the process of separating the components or substances from a liquid mixture by using selective boiling and condensation, usually inside an apparatus known as a still. Dry distillation is the heating ...

, used for mixtures of liquids with different boiling points *

Drying Drying is a mass transfer process consisting of the removal of water or another solvent by evaporation from a solid, semi-solid or liquid. This process is often used as a final production step before selling or packaging products. To be considered ...

, removes liquid from a solid by vaporization or evaporation

Electrophoresis

Electrophoresis Electrophoresis, from Ancient Greek ἤλεκτρον (ḗlektron, "amber") and φόρησις (phórēsis, "the act of bearing"), is the motion of dispersed particles relative to a fluid under the influence of a spatially uniform electric fie ...

, separates organic molecules based on their different interaction with a

gel A gel is a semi-solid that can have properties ranging from soft and weak to hard and tough. Gels are defined as a substantially dilute cross-linked system, which exhibits no flow when in the steady-state, although the liquid phase may still di ...

under an electric potential (i.e., different travel) *

Capillary electrophoresis Capillary electrophoresis (CE) is a family of electrokinetic separation methods performed in submillimeter diameter capillaries and in micro- and nanofluidic channels. Very often, CE refers to capillary zone electrophoresis (CZE), but other elect ...

* Electrostatic separation, works on the principle of corona discharge, where two plates are placed close together and high voltage is applied. This high voltage is used to separate the ionized particles. *

Elutriation Elutriation is a process for separating particles based on their size, shape and density, using a stream of gas or liquid flowing in a direction usually opposite to the direction of sedimentation. This method is mainly used for particles small ...

Evaporation Evaporation is a type of vaporization that occurs on the surface of a liquid as it changes into the gas phase. High concentration of the evaporating substance in the surrounding gas significantly slows down evaporation, such as when humidi ...

Extraction

Extraction Extraction may refer to: Science and technology Biology and medicine * Comedo extraction, a method of acne treatment * Dental extraction, the surgical removal of a tooth from the mouth Computing and information science * Data extraction, the pr ...

** Leaching ** Liquid-liquid extraction **

Solid phase extraction Solid-phase extraction (SPE) is an extractive technique by which compounds that are dissolved or suspended in a liquid mixture are separated from other compounds in the mixture according to their physical and chemical properties. Analytical labor ...

Supercritical fluid extraction Supercritical fluid extraction (SFE) is the process of separating one component (the extractant) from another (the matrix) using supercritical fluids as the extracting solvent. Extraction is usually from a solid matrix, but can also be from liquids. ...

** Subcritical fluid extraction *

Field flow fractionation Field-flow fractionation, abbreviated FFF, is a separation technique which does not have a stationary phase. It is similar to liquid chromatography as it works on dilute solutions or suspensions of the solute. Separation is achieved by applying ...

Flotation

* Flotation **

Dissolved air flotation Dissolved air flotation (DAF) is a water treatment process that clarifies wastewaters (or other waters) by the removal of suspended matter such as oil or solids. The removal is achieved by dissolving air in the water or wastewater under pressure an ...

, removes suspended solids non-selectively from slurry by bubbles that are generated by air coming out of solution **

Froth flotation Froth flotation is a process for selectively separating hydrophobic materials from hydrophilic. This is used in mineral processing, paper recycling and waste-water treatment industries. Historically this was first used in the mining industry, wher ...

, recovers valuable, hydrophobic solids by attachment to air bubbles generated by mechanical agitation of an air-slurry mixture, which floats, and are recovered **

Deinking Deinking is the industrial process of removing printing ink from paperfibers of recycled paper to make deinked pulp. The key in the deinking process is the ability to detach ink from the fibers. This is achieved by a combination of mechanical ...

, separating hydrophobic ink particles from the hydrophilic paper pulp in

paper recycling The recycling of paper is the process by which waste paper is turned into new paper products. It has a number of important benefits: It saves waste paper from occupying homes of people and producing methane as it breaks down. Because paper fib ...

Flocculation Flocculation, in the field of chemistry, is a process by which colloidal particles come out of suspension to sediment under the form of floc or flake, either spontaneously or due to the addition of a clarifying agent. The action differs from pr ...

, separates a solid from a liquid in a colloid, by use of a flocculant, which promotes the solid clumping into flocs *

–

Mesh A mesh is a barrier made of connected strands of metal, fiber, or other flexible or ductile materials. A mesh is similar to a web or a net in that it has many attached or woven strands. Types * A plastic mesh may be extruded, oriented, ex ...

, bag and paper filters are used to remove large particulates suspended in fluids (e.g.,

fly ash Fly ash, flue ash, coal ash, or pulverised fuel ash (in the UK) plurale tantum: coal combustion residuals (CCRs)is a coal combustion product that is composed of the particulates (fine particles of burned fuel) that are driven out of coal-fired ...

) while membrane processes including

microfiltration Microfiltration is a type of physical filtration process where a contaminated fluid is passed through a special pore-sized membrane filter to separate microorganisms and suspended particles from process liquid. It is commonly used in conjunction ...

ultrafiltration Ultrafiltration (UF) is a variety of membrane filtration in which forces such as pressure or concentration gradients lead to a separation through a semipermeable membrane. Suspended solids and solutes of high molecular weight are retained in the ...

nanofiltration Nanofiltration is a membrane filtration process used most often to soften and disinfect water. Overview Nanofiltration is a membrane filtration-based method that uses nanometer sized pores through which particles smaller than 10 nanometers pa ...

reverse osmosis Reverse osmosis (RO) is a water purification process that uses a partially permeable membrane to separate ions, unwanted molecules and larger particles from drinking water. In reverse osmosis, an applied pressure is used to overcome osmotic pr ...

dialysis (biochemistry) In chemistry, dialysis is the process of separating molecules in solution by the difference in their rates of diffusion through a semipermeable membrane, such as dialysis tubing. Dialysis is a common laboratory technique that operates on the sa ...

utilising

synthetic membrane An artificial membrane, or synthetic membrane, is a synthetically created membrane which is usually intended for separation purposes in laboratory or in industry. Synthetic membranes have been successfully used for small and large-scale industrial ...

s, separates

micrometre The micrometre ( international spelling as used by the International Bureau of Weights and Measures; SI symbol: μm) or micrometer ( American spelling), also commonly known as a micron, is a unit of length in the International System of Uni ...

-sized or smaller species *

Fractional distillation Fractional distillation is the separation of a mixture into its component parts, or fractions. Chemical compounds are separated by heating them to a temperature at which one or more fractions of the mixture will vaporize. It uses distillation to ...

Fractional freezing Fractional freezing is a process used in process engineering and chemistry to separate substances with different melting points. It can be done by partial melting of a solid, for example in zone refining of silicon or metals, or by partial c ...

* Oil-water separation, gravimetrically separates suspended oil droplets from waste water in

oil refineries An oil refinery or petroleum refinery is an industrial process plant where petroleum (crude oil) is transformed and refined into useful products such as gasoline (petrol), diesel fuel, asphalt base, fuel oils, heating oil, kerosene, liquefi ...

petrochemical Petrochemicals (sometimes abbreviated as petchems) are the chemical products obtained from petroleum by refining. Some chemical compounds made from petroleum are also obtained from other fossil fuels, such as coal or natural gas, or renewable so ...

and

chemical plant A chemical plant is an industrial process plant that manufactures (or otherwise processes) chemicals, usually on a large scale. The general objective of a chemical plant is to create new material wealth via the chemical or biological transfor ...

natural gas processing Natural-gas processing is a range of industrial processes designed to purify raw natural gas by removing impurities, contaminants and higher molecular mass hydrocarbons to produce what is known as ''pipeline quality'' dry natural gas. Natural gas ...

plants and similar industries *

Magnetic separation Magnetic separation is the process of separating components of mixtures by using a magnet to attract magnetic substances. The process that is used for magnetic separation separates non-magnetic substances from those which are magnetic. This techniq ...

Precipitation In meteorology, precipitation is any product of the condensation of atmospheric water vapor that falls under gravitational pull from clouds. The main forms of precipitation include drizzle, rain, Rain and snow mixed, sleet, snow, ice pellets, ...

* Recrystallization * Scrubbing, separation of particulates (solids) or gases from a gas stream using liquid. *

Sedimentation Sedimentation is the deposition of sediments. It takes place when particles in suspension settle out of the fluid in which they are entrained and come to rest against a barrier. This is due to their motion through the fluid in response to the ...

, separates using vocal density pressure differences **

Gravity separation Gravity separation is an industrial method of separating two components, either a suspension, or dry granular mixture where separating the components with gravity is sufficiently practical: i.e. the components of the mixture have different specific ...

Sieving A sieve, fine mesh strainer, or sift, is a device for separating wanted elements from unwanted material or for controlling the particle size distribution of a sample, using a screen such as a woven mesh or net or perforated sheet material. ...

* Stripping * Sublimation * Vapor-liquid separation, separates by gravity, based on the Souders-Brown equation *

Winnowing Winnowing is a process by which chaff is separated from grain. It can also be used to remove pests from stored grain. Winnowing usually follows threshing in grain preparation. In its simplest form, it involves throwing the mixture into the ...

Zone refining Zone melting (or zone refining, or floating-zone method, or floating-zone technique) is a group of similar methods of purifying crystals, in which a narrow region of a crystal is melted, and this molten zone is moved along the crystal. The molte ...

References

External links

Separation of Mixtures Using Different Techniques
, instructions for performing classroom experiments
Separation of Components of a Mixture
, instructions for performing classroom experiments {{Authority control Analytical chemistry Unit operations Separation processes