Steve Horvath is a German–American aging researcher, geneticist, and biostatistician. As the familyname Horváth indicates, he is of hungarian ancestry. He is a professor at the

University of California, Los Angeles The University of California, Los Angeles (UCLA) is a public university, public Land-grant university, land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a Normal school, teachers colle ...

known for developing the Horvath aging clock, which is a highly accurate molecular biomarker of aging, and for developing weighted correlation network analysis. The recipient of several research awards he has studied genomic biomarkers of aging, the

aging process Ageing ( BE) or aging ( AE) is the process of becoming older. The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal ...

, and many age related diseases/conditions. Horvath is a scientist at the anti-aging startup Altos Labs.

Background

Horvath was born in

Frankfurt Frankfurt, officially Frankfurt am Main (; Hessian: , " Frank ford on the Main"), is the most populous city in the German state of Hesse. Its 791,000 inhabitants as of 2022 make it the fifth-most populous city in Germany. Located on its ...

Germany Germany, officially the Federal Republic of Germany (FRG),, is a country in Central Europe. It is the most populous member state of the European Union. Germany lies between the Baltic and North Sea to the north and the Alps to the sou ...

and received his

Bachelor of Science A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University o ...

in Mathematics and Physics at the

Technical University of Berlin The Technical University of Berlin (official name both in English and german: link=no, Technische Universität Berlin, also known as TU Berlin and Berlin Institute of Technology) is a public research university located in Berlin, Germany. It was ...

, graduating in 1989. He received his Ph.D. in mathematics at the

UNC Chapel Hill UNC is a three-letter abbreviation that may refer to: Education * University of Northern California (disambiguation), which may refer to: ** University of Northern California (Santa Rosa), in Petaluma, California, United States ** University of N ...

in 1995 and his Sc.D. in biostatistics at Harvard in 2000. In 2000, Horvath joined the faculty of the University of California, Los Angeles, where he is a professor of

human genetics Human genetics is the study of inheritance as it occurs in human beings. Human genetics encompasses a variety of overlapping fields including: classical genetics, cytogenetics, molecular genetics, biochemical genetics, genomics, population gen ...

at the David Geffen School of Medicine at

UCLA The University of California, Los Angeles (UCLA) is a public university, public Land-grant university, land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a Normal school, teachers colle ...

and of

biostatistics Biostatistics (also known as biometry) are the development and application of statistical methods to a wide range of topics in biology. It encompasses the design of biological experiments, the collection and analysis of data from those experime ...

at the UCLA Fielding School of Public Health.

Work on the epigenetic clock

Horvath's development of the

DNA methylation DNA methylation is a biological process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter, DNA methylation typically acts ...

based age estimation method known as

epigenetic clock An epigenetic clock is a biochemical test that can be used to measure age. The test is based on DNA methylation levels, measuring the accumulation of methyl groups to one's DNA molecules. History The strong effects of age on DNA methylation le ...

was featured in

Nature Nature, in the broadest sense, is the physical world or universe. "Nature" can refer to the phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. Although humans ar ...

magazine. In 2011, Horvath co-authored the first article that described an age estimation method based on DNA methylation levels from saliva. In 2013 Horvath published a single author article on a multi-tissue age estimation method that applies to all nucleated cells, tissues, and organs. This discovery, known as the Horvath clock, was unexpected because cell types differ in terms of their DNA methylation patterns and age related DNA methylation changes tend to be tissue specific. In his article, he demonstrated that estimated age, also referred to as DNA methylation age, has the following properties: it is close to zero for embryonic and

induced pluripotent stem cell Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. The iPSC technology was pioneered by Shinya Yamanaka's lab in Kyoto, Japan, who showed ...

s, it correlates with cell passage number; it gives rise to a highly heritable measure of age acceleration; and it is applicable to chimpanzees. Since the Horvath clock allows one to contrast the ages of different tissues from the same individuals, it can be used to identify tissues that show evidence of increased or decreased age.

Age related conditions and phenotypes

Horvath co-authored the first articles demonstrating that DNA methylation age predicts life-expectancy and is positively associated with

obesity Obesity is a medical condition, sometimes considered a disease, in which excess body fat has accumulated to such an extent that it may negatively affect health. People are classified as obese when their body mass index (BMI)—a person's ...

HIV The human immunodeficiency viruses (HIV) are two species of '' Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immu ...

infection, Alzheimer's disease, cognitive decline,

Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms becom ...

Huntington's disease Huntington's disease (HD), also known as Huntington's chorea, is a neurodegenerative disease that is mostly inherited. The earliest symptoms are often subtle problems with mood or mental abilities. A general lack of coordination and an uns ...

, early

menopause Menopause, also known as the climacteric, is the time in women's lives when menstrual periods stop permanently, and they are no longer able to bear children. Menopause usually occurs between the age of 47 and 54. Medical professionals often d ...

, and

Werner syndrome Werner syndrome (WS) or Werner's syndrome, also known as "adult progeria",James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology''. (10th ed.). Saunders. . is a rare, autosomal recessive disord ...

Genetics of aging

Horvath published the first article demonstrating that trisomy 21 (

Down syndrome Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with child development, physical growth delays, mild to moderate ...

) is associated with strong epigenetic age acceleration effects in both blood and brain tissue. Using

genome-wide association studies In genomics, a genome-wide association study (GWA study, or GWAS), also known as whole genome association study (WGA study, or WGAS), is an observational study of a genome-wide set of genetic variants in different individuals to see if any varian ...

, Horvath's team identified the first genetic markers (SNPs) that exhibit genome-wide significant associations with epigenetic aging rates – in particular, the first genome-wide significant genetic loci associated with epigenetic aging rates in blood notably the telomerase reverse transcriptase gene (

TERT Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. T ...

) locus. As part of this work, his team uncovered a paradoxical relationship: genetic variants associated with longer leukocyte telomere length in the TERT gene paradoxically confer higher epigenetic age acceleration in blood.

Work in biodemography

Horvath proposed that slower epigenetic aging rates could explain the mortality advantage of women and the Hispanic mortality paradox.

Lifestyle factors and nutrition

Horvath published the first large scale study of the effect of lifestyle factors on epigenetic aging rates. These cross sectional of epigenetic aging rates in blood confirm the conventional wisdom regarding the benefits of education, eating a high plant diet with lean meats, moderate alcohol consumption, physical activity and the risks associated with

metabolic syndrome Metabolic syndrome is a clustering of at least three of the following five medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). Metabolic syndrom ...

Epigenetic clock theory of aging

Horvath and Raj proposed an epigenetic clock theory of aging which views biological aging as an unintended consequence of both developmental programs and maintenance program, the molecular footprints of which give rise to DNA methylation age estimators. DNAm age is viewed as a proximal readout of a collection of innate ageing processes that conspire with other, independent root causes of aging, to the detriment of tissue function.

Weighted correlation network analysis

Horvath and members of his lab developed a widely used systems biological data mining technique known as weighted correlation network analysis. He published a book on weighted network analysis and genomic applications.

Awards and honors

Horvath has won several awards for his work on the epigenetic clock. * 2017 Allen Distinguished Investigator award for clock studies in vertebrates * 2019 Open Philanthropy Project award for mechanistic studies of the epigenetic clock * 2019 Schober Award for outstanding and innovative research in the field of ageing * 2022 Nathan W. Shock Award * 2022

Fellow of the American Statistical Association Like many other academic professional societies, the American Statistical Association (ASA) uses the title of Fellow of the American Statistical Association as its highest honorary grade of membership. The number of new fellows per year is limited ...

References

{{DEFAULTSORT:Horvath, Steve 1967 births American people of Hungarian descent German people of Hungarian descent Educators from California David Geffen School of Medicine at UCLA faculty Biogerontologists Harvard School of Public Health alumni Living people University of North Carolina alumni Fellows of the American Statistical Association