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''Splice'' is a 2009
science fiction Science fiction (often shortened to sci-fi or abbreviated SF) is a genre of speculative fiction that deals with imaginative and futuristic concepts. These concepts may include information technology and robotics, biological manipulations, space ...
horror film Horror is a film genre that seeks to elicit physical or psychological fear in its viewers. Horror films often explore dark subject matter and may deal with Transgressive art, transgressive topics or themes. Broad elements of the genre include Mo ...
directed by
Vincenzo Natali Vincenzo Natali (born 1969) is an American-born Canadian film director and screenwriter, known for writing and directing science fiction and horror films such as ''Cube'', '' Cypher'', ''Nothing'', and '' Splice''. Early life and education Natal ...
and starring
Adrien Brody Adrien Nicholas Brody (born April 14, 1973) is an American actor. He won the Academy Award for Best Actor for his portrayal of Polish pianist Władysław Szpilman in Roman Polanski's war drama '' The Pianist'' (2002) becoming the youngest acto ...
,
Sarah Polley Sarah Ellen Polley (born January 8, 1979) is a Canadian filmmaker, writer, political activist and actress.Howell, Peter (September 24, 199"Nobody's Starlet: Toronto's Sarah Polley is Only 20 but already a veteran actor so secure in her craft s ...
, and Delphine Chanéac. The story concerns experiments in genetic engineering being done by a young scientific couple, who attempt to introduce human
DNA Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...
into their work of splicing animal genes resulting in the creation of a
human–animal hybrid A human–animal hybrid and animal–human hybrid is an organism that incorporates elements from both humans and non-human animals. Technically, in a ''human–animal Hybrid (biology), hybrid'', each cell has both human and non-human genetic mate ...
.
Guillermo del Toro Guillermo del Toro Gómez (; born 9 October 1964) is a Mexican filmmaker, author, and artist. His work has been characterized by a strong connection to fairy tales, Gothic fiction, gothicism and horror fiction, horror often blending the genres ...
, Don Murphy, and
Joel Silver Joel Silver (born July 14, 1952) is an American film producer. Life and career Silver was born and raised in South Orange, New Jersey, the son of a writer and a public relations executive. His family is Jewish. He attended Columbia High School ...
are credited as executive producers of this film. Theatrically released on June 4, 2010, it received generally positive reviews from critics and grossed $27.1 million against a $30 million production budget.


Plot

Genetic engineers Clive Nicoli and the mentally unstable Elsa Kast hope to achieve fame by splicing animal
DNA Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...
to create hybrids for medical use at the company N.E.R.D. (Nucleic Exchange Research and Development). Their work has yielded Fred and Ginger, two large
vermiform Vermes (" vermin/vermes") is an obsolete taxon used by Carl Linnaeus and Jean-Baptiste Lamarck for non-arthropod invertebrate animals. Linnaeus In Linnaeus's ''Systema Naturae'', the Vermes had the rank of class, occupying the 6th (and last) ...
creatures intended as mates for each other. After successfully mating them, Clive and Elsa plan to create a revolutionary
human–animal hybrid A human–animal hybrid and animal–human hybrid is an organism that incorporates elements from both humans and non-human animals. Technically, in a ''human–animal Hybrid (biology), hybrid'', each cell has both human and non-human genetic mate ...
. Their employers Joan Chorot and William Barlow forbid this and order them to focus on identifying and extracting proteins from Fred and Ginger for drug production. However, Clive and Elsa follow their plans in secret and develop a
viable Viability or viable may refer to: Biology, medicine or ecology * Viability selection, the selection of individual organisms who can survive until they are able to reproduce * Fetal viability, the ability of a fetus to survive outside of the uter ...
prepubescent female creature. Although they planned to terminate before the hybrid reached full term, Elsa persuades Clive to let it live. The hybrid physically ages much faster than humans and mentally develops like a human child. After it spells out NERD with toys after seeing the acronym on Elsa's shirt, Elsa names it "Dren". Clive’s brother Gavin discovers Dren but flees after she jumps on him. Elsa notices Dren has a fever and tries to cool her in an industrial-sized sink of cold water. Clive holds Dren underwater. This forces Dren to use her gills, revealing she is amphibious. Elsa forms a motherly bond with Dren. Meanwhile, Elsa and Clive neglect their work with Fred and Ginger. At a publicized presentation, Fred and Ginger fight and kill each other. Ginger had spontaneously changed into a male, but Elsa and Clive failed to notice as they were focused on Dren. The couple moves Dren to the isolated farm where Elsa grew up. Dren reveals she has carnivorous tendencies and retractable wings and enters adolescence. She grows bored of confinement, but Elsa and Clive fear she might be discovered outside. Clive realizes the human DNA used to create Dren is not that of an anonymous donor, as Elsa told him, but Elsa's. After Dren kills her pet cat with the stinger on her tail, Elsa restrains her roughly and amputates the stinger, then uses it to synthesize a protein for their work. While alone with each other, Dren uses her pheromones to seduce Clive and has sex with him, much to Elsa's horror. Clive accuses Elsa of not wanting a "normal" child prior to that because of her fear of losing control. They return to the farm to terminate Dren but find her seemingly dying. William Barlow discovers human DNA in Dren's protein samples and arrives at the barn with Gavin, who revealed the location. Elsa says Dren is dead and buried behind the barn. Having spontaneously metamorphosed into a male, Dren rises from the grave and attacks them, killing Barlow and Gavin before raping Elsa. Clive attacks Dren to help Elsa but is overpowered by Dren. Elsa attacks Dren to help Clive but hesitates, which allows Dren to kill Clive. Elsa then kills Dren. In an office tower, Joan tells Elsa that Dren's body contained numerous
biochemical Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, ...
compounds, for which the company is filing patents. She offers a visibly pregnant Elsa a large sum of money to go through with the pregnancy that Elsa accepts.


Cast

*
Adrien Brody Adrien Nicholas Brody (born April 14, 1973) is an American actor. He won the Academy Award for Best Actor for his portrayal of Polish pianist Władysław Szpilman in Roman Polanski's war drama '' The Pianist'' (2002) becoming the youngest acto ...
as Clive Nicoli *
Sarah Polley Sarah Ellen Polley (born January 8, 1979) is a Canadian filmmaker, writer, political activist and actress.Howell, Peter (September 24, 199"Nobody's Starlet: Toronto's Sarah Polley is Only 20 but already a veteran actor so secure in her craft s ...
as Elsa Kast * Delphine Chanéac as Dren ** Abigail Chu as Child Dren * Brandon McGibbon as Gavin Nicoli * Simona Maicanescu as Joan Chorot *
David Hewlett David Ian Hewlett (born 18 April 1968) is an English-Canadian actor, writer and director, known for his role as Dr. Rodney McKay in the ''Stargate'' science-fiction franchise. He first gained fame for his roles as Grant Jansky in the Canadian ...
as William Barlow


Production

''Splice'' was written by director Vincenzo Natali and screenwriters Antoinette Terry Bryant and Doug Taylor. The script was originally meant to follow up Natali's ''
Cube A cube or regular hexahedron is a three-dimensional space, three-dimensional solid object in geometry, which is bounded by six congruent square (geometry), square faces, a type of polyhedron. It has twelve congruent edges and eight vertices. It i ...
'' (1997), but the budget and restricted technology hindered the project. In 2007, the project entered active development as a 75% Canadian and 25% French co-production, receiving a budget of $26 million. Natali said ''Splice'' is "about our genetic future" and upcoming scientific issues. He described it as "a serious film and an emotional one" with disturbing sexual themes. He said he wanted to "create something shocking but also very subtle and completely believable". In October 2007, actors Brody and Polley were cast into the lead roles. Production began the following November in Toronto. It was aided by
Telefilm Canada Telefilm Canada is a Canadian Crown corporation that supports Canada's audiovisual industry. Headquartered in Montreal, Telefilm Canada provides services to the Canadian audiovisual industry with four regional offices in Vancouver, British Colu ...
's funding of US$2.5 million. Filming took place in Toronto and concluded in February 2008. Natali said that although he did not personally intend for any sequels to be made, they were a possibility.


Release

The film premiered on October 6, 2009 at the
Sitges Film Festival SITGES - International Fantastic Film Festival of Catalonia () is an annual film festival held in Sitges, Catalonia, Spain. It specializes in fantasy film, fantasy, Horror film, horror and Cult film, cult films. Established in 1968, the festiva ...
, where it won "Best Special Effects" and was in the running for "Best Film", and was part of the 2010
Sundance Film Festival The Sundance Film Festival is an annual film festival organized by the Sundance Institute. It is the largest independent film festival in the United States, with 423,234 combined in-person and online viewership in 2023. The festival has acted ...
in
Park City, Utah Park City is a city in Utah, United States. Most of the city is within Summit County, Utah, Summit County, with some portions extending into Wasatch County, Utah, Wasatch County. It is considered to be part of the Wasatch Back. The city is sou ...
. After a bidding war with Apparition,
The Weinstein Company The Weinstein Company, LLC (usually credited or abbreviated as TWC) was an American independent film production and distribution company, which was founded in New York City by Bob and Harvey Weinstein on March 10, 2005. TWC was one of the larg ...
,
Newmarket Films Newmarket Films, LLC was an American Privately held company, privately owned independent film production and distribution company and a former film distribution subsidiary of Newmarket Capital Group. The company produced such films as ''The Mexic ...
,
First Look Studios First Look Studios, Inc. was an American independent film and home video distributor based in Los Angeles, California. The company specialized in the acquisition and direct distribution of, and worldwide license and sale of distribution rights t ...
, and
Samuel Goldwyn Films Samuel Goldwyn Films, LLC is an American film company that licenses, releases and distributes art-house, independent and foreign films. It was founded by Samuel Goldwyn Jr., the son of the Hollywood business magnate/mogul, Samuel Goldwyn. Th ...
,
Dark Castle Entertainment Dark Castle Entertainment is a Film studio, film production label of OEG Inc. It was founded in 1998 originally as a film production company by producers Joel Silver & Gilbert Adler and filmmaker Robert Zemeckis, with most of its productions cen ...
purchased the U.S rights to the film and the worldwide rights to any possible sequels in February 2010, thinking they had "found the next ''
Paranormal Activity Paranormal events are purported phenomena described in popular culture, folk, and other non-scientific bodies of knowledge, whose existence within these contexts is described as being beyond the scope of normal scientific understanding. Not ...
''". The film received a wide release in the United States on June 4, 2010, with Warner Bros. Pictures as distributor. The trailer was attached to two other Warner Bros. movies, '' The Losers'' and ''
A Nightmare on Elm Street ''A Nightmare on Elm Street'' is a 1984 American Supernatural horror film, supernatural slasher film written and directed by Wes Craven and produced by Robert Shaye. It is the first installment in the A Nightmare on Elm Street (franchise), ''A ...
''. The film opened on June 4, 2010 in
wide release In the motion picture industry, a wide release (short for nationwide release) is a film playing at the same time at cinemas in most markets across a country. This is in contrast to the formerly common practice of a roadshow theatrical release in ...
to a $7.4 million opening weekend in 2,450 theaters, averaging $3,014 per theater. ''Splice'' was released on DVD and Blu-ray on October 5, 2010, in the US and on November 29, 2010, in the UK.


Reception

Audiences polled by
CinemaScore CinemaScore is an American market research firm based in Las Vegas. It surveys film audiences to rate their viewing experiences with letter grades, reports the results, and forecasts box office receipts from the data. Background Ed Mintz, who ...
gave the film an average grade of "D" on an A+ to F scale.
Manohla Dargis Manohla June Dargis ( ) is an American film critic. She is the chief film critic for ''The New York Times''. She is a five-time finalist for the Pulitzer Prize for Criticism. Career Before being a film critic for ''The New York Times'', Dargis ...
of ''
The New York Times ''The New York Times'' (''NYT'') is an American daily newspaper based in New York City. ''The New York Times'' covers domestic, national, and international news, and publishes opinion pieces, investigative reports, and reviews. As one of ...
'' wrote that Natali "hasn't reinvented the horror genre" but "has done the next best thing with an intelligent movie that, in between its small boos and an occasional hair-raising jolt, explores chewy issues like bioethics, abortion, corporate-sponsored science, commitment problems between lovers and even Freudian-worthy family dynamics." Andrew O'Hehir from ''
Salon Salon may refer to: Common meanings * Beauty salon A beauty salon or beauty parlor is an establishment that provides Cosmetics, cosmetic treatments for people. Other variations of this type of business include hair salons, spas, day spas, ...
'' said "Dark, sleek, funny and creepily infectious, the genetic-engineering horror-comedy ''Splice'' is a dynamic comeback vehicle for Canadian genre director Vincenzo Natali, who made a splash a few years ago with ''Cube''."
Lisa Schwarzbaum Lisa Schwarzbaum (born July 5, 1952) is an American film critic. She joined ''Entertainment Weekly'' as a senior writer in 1991, working as a film critic for the magazine alongside Owen Gleiberman from 1995 to 2013. Early life Lisa Schwarzbaum w ...
from ''
Entertainment Weekly ''Entertainment Weekly'' (sometimes abbreviated as ''EW'') is an American online magazine, digital-only entertainment magazine based in New York City, published by Dotdash Meredith, that covers film, television, music, Broadway theatre, books, ...
'' gave the film an A− and stated, "The outstanding creature effects by Howard Berger only get more astonishing as ''Splice'' splits into an eerie horror picture, then divides again into something out of ''Rosemary's Baby''."
Roger Ebert Roger Joseph Ebert ( ; June 18, 1942 – April 4, 2013) was an American Film criticism, film critic, film historian, journalist, essayist, screenwriter and author. He wrote for the ''Chicago Sun-Times'' from 1967 until his death in 2013. Eber ...
from the ''
Chicago Sun-Times The ''Chicago Sun-Times'' is a daily nonprofit newspaper published in Chicago, Illinois, United States. Since 2022, it is the flagship paper of Chicago Public Media, and has long held the second largest circulation among Chicago newspaper ...
'' called it "well done and intriguing" but said it is disappointing in that it does not explore Dren's persona. Comparing the film to
David Cronenberg David Paul Cronenberg (born March 15, 1943) is a Canadian film director, screenwriter, producer and actor. He is a principal originator of the body horror genre, with his films exploring visceral bodily transformation, infectious diseases, and ...
's '' The Brood'',
Peter Travers Peter Joseph Travers (born June 27, 1943) is an American film critic, journalist, and television presenter. He reviews films for ABC News and previously served as a movie critic for ''People'' and ''Rolling Stone''. Travers also hosts the film i ...
from ''
Rolling Stone ''Rolling Stone'' is an American monthly magazine that focuses on music, politics, and popular culture. It was founded in San Francisco, California, in 1967 by Jann Wenner and the music critic Ralph J. Gleason. The magazine was first known fo ...
'' said, "Played as a child by Abigail Chu and as an adult by Delphine Chanéac, Dren morphs into a special-effects miracle, sexy and scary in equal doses." and gave the film 3 out of 4. Also comparing the sex scenes to Cronenberg's work, Mick LaSalle of the ''
San Francisco Chronicle The ''San Francisco Chronicle'' is a newspaper serving primarily the San Francisco Bay Area of Northern California. It was founded in 1865 as ''The Daily Dramatic Chronicle'' by teenage brothers Charles de Young and M. H. de Young, Michael H. ...
'' rated it 2/4 stars and wrote that while it has several disgusting scenes, it is "a regulation monster movie" that is "too dumb to be serious and too slow to be entertaining".
Richard Roeper Richard E. Roeper (born October 17, 1959) is an American writer. He is a former columnist and film critic for the '' Chicago Sun-Times'', where he wrote for 39 years dating back to 1986 until his departure in 2025. He co-hosted the television s ...
panned ''Splice'', calling it one of the worst movies of 2010. He gave the film a D+, calling it "ridiculous" but giving it credit for trying to be different.


Accolades

''Splice'' won the 2011 Telefilm Golden Box Office Award, CAD$40,000, for being the highest-grossing Canadian feature film in English in 2010. The film was nominated for Best Science Fiction Film at 37th Saturn Awards, but lost to ''
Inception ''Inception'' is a 2010 science fiction action heist film written and directed by Christopher Nolan, who also produced it with Emma Thomas, his wife. The film stars Leonardo DiCaprio as a professional thief who steals information by inf ...
'', another film from
Warner Bros. Warner Bros. Entertainment Inc. (WBEI), commonly known as Warner Bros. (WB), is an American filmed entertainment studio headquartered at the Warner Bros. Studios complex in Burbank, California and the main namesake subsidiary of Warner Bro ...


References


External links

* * * *
Podcast Interview with Vincenzo Natali about ''Splice'' (daily.greencine.com)
{{DEFAULTSORT:Splice (Film) 2009 films 2000s science fiction horror films Canadian LGBTQ-related films Canadian science fiction horror films English-language Canadian films English-language French films French LGBTQ-related films Warner Bros. films French science fiction horror films LGBTQ-related science fiction horror films 2000s pregnancy films 2000s monster movies 2000s English-language films Biopunk films Gaumont (company) films Copperheart Entertainment films Dark Castle Entertainment films Films about genetic engineering Films about cloning Films about ectogenesis Films about scientists Films set on farms Fictional human hybrids Films shot in Toronto Films directed by Vincenzo Natali Films about rape Films with screenplays by Vincenzo Natali Transgender-related films 2000s Canadian films 2000s French films 2009 LGBTQ-related films English-language science fiction horror films Films produced by Steve Hoban